Methods in testing interrelationships between excretion of drugs via urine and bile

Fleck, Christian; Bräunlich, H

doi:10.1016/0163-7258(84)90022-6

Cited by 22 publications

(12 citation statements)

References 140 publications

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“…As the excretory capabilities of the two organs overlap, damage to one system might be compensated by the other [1,2]. Little is known about the conditions under which the compensation of the loss of one route by the other is possible.…”

Section: Discussionmentioning

confidence: 99%

“…In some cases, the loss of one route of elimination can be compensated by the other [1][2][3]. It must also be mentioned that impairment of liver or kidney functions can cause syndromes characterized by injury of the alternative elimination organ [1,4,5]. For example, prolonged cholestasis, characterized by retention of bile compound, may cause renal damage (reduction in renal hemodynamics, impairment of renal excretion of water and salts, and sensitization of the kidney to anoxia damage) which sometimes leads to renal failure.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compensation Increase in Organic Anion Excretion in Rats with Acute Biliary Obstruction: Role of the Renal Organic Anion Transporter 1

Brandoni

Quaglia²,

Torres³

2003

Pharmacology

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The purpose of the present study was to examine in rats the effects of acute bile duct ligation on the expression of the organic anion transporter 1 in the kidney and the consequences of these effects on the systemic clearance of organic anions, particularly on p-aminohippurate (PAH) clearance, since it has been viewed as the prototypic organic anion. Male Wistar rats underwent bile duct ligation (BDL rats). Pair-fed sham-operated rats served as controls. All studies were carried out 21 h after surgery. Our data revealed that BDL rats had a higher expression of organic transporter 1 protein in kidney cortex homogenates. Accordingly, systemic clearance of PAH and urinary excretion of PAH were both higher in BDL rats. These findings suggest that impairment of the liver function after BDL is followed by a distinct and statistically significant increase in renal excretion of PAH, indicating a possible compensation mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compensation Increase in Organic Anion Excretion in Rats with Acute Biliary Obstruction: Role of the Renal Organic Anion Transporter 1

Brandoni

Quaglia²,

Torres³

2003

Pharmacology

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“…The kidneys and liver are the major routes for organic anion elimination (Fleck and Bräunlich 1991;Burckhardt and Pritchard 2000). Numerous compounds, such as drugs, environmental substances, plant and animal toxins, and metabolites of both foreign and endogenous origins, are classified as organic anions.…”

Section: Discussionmentioning

confidence: 99%

“…REMOVAL OF ORGANIC ANIONS from circulation is an essential function of the liver and the kidneys (Fleck and Bräunlich 1991;Burckhardt and Pritchard 2000). Because many of these substances are toxic to the body, their elimination is essential for homeostasis.…”

mentioning

confidence: 99%

Characterization of the Mechanisms Involved in the Increased Renal Elimination of Bromosulfophthalein During Cholestasis: Involvement of Oatp1

Brandoni

Torres

2009

J Histochem Cytochem.

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S U M M A R Y The kidneys and liver are the major routes for organic anion elimination. We have recently shown that acute obstructive jaundice is associated with increased systemic and renal elimination of two organic anions, p-aminohippurate and furosemide, principally excreted through urine. This study examined probable adaptive mechanisms involved in renal elimination of bromosulfophthalein (BSP), a prototypical organic anion principally excreted in bile, in rats with acute obstructive jaundice. Male Wistar rats underwent bile duct ligation (BDL rats). Pair-fed sham-operated rats served as controls. BSP renal clearance was performed by conventional techniques. Renal organic aniontransporting polypeptide 1 (Oatp1) expression was evaluated by immunoblotting and IHC. Excreted, filtered, and secreted loads of BSP were all higher in BDL rats compared with Sham rats. The higher BSP filtered load resulted from the increase in plasma BSP concentration in BDL rats, because glomerular filtration rate showed no difference with the Sham group. The increase in the secreted load might be explained by the higher expression of Oatp1 observed in apical membranes from kidneys of BDL animals. This likely adaptation to hepatic injury, specifically in biliary components elimination, might explain, at least in part, the huge increase in BSP renal excretion observed in this experimental model. (J Histochem Cytochem 57:449-456, 2009)

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Transport and Metabolism in the Hepatobiliary System

Meijer

1989

Comprehensive Physiology

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Methods in testing interrelationships between excretion of drugs via urine and bile

Cited by 22 publications

References 140 publications

Compensation Increase in Organic Anion Excretion in Rats with Acute Biliary Obstruction: Role of the Renal Organic Anion Transporter 1

Compensation Increase in Organic Anion Excretion in Rats with Acute Biliary Obstruction: Role of the Renal Organic Anion Transporter 1

Characterization of the Mechanisms Involved in the Increased Renal Elimination of Bromosulfophthalein During Cholestasis: Involvement of Oatp1

Transport and Metabolism in the Hepatobiliary System

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