Methods of biological fluids sample preparation – biogenic amines, methylxanthines, water‐soluble vitamins

Płonka, Joanna

doi:10.1002/bmc.3353

Cited by 11 publications

(8 citation statements)

References 90 publications

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“…Likewise, there are also significant differences in the concentrations of BAs in the matrix according to the body fluid. For example, the amount of DA in the urine of a healthy person is up to 10 times greater than the amount of NE, while the total plasma catecholamine content is 10 times higher than the content of NE [19]. For the comprehensive analysis of BAs, it is necessary to develop preparation procedures for samples of different body fluids.…”

Section: Sample Preparationmentioning

confidence: 99%

Recent Trends in the Quantification of Biogenic Amines in Biofluids as Biomarkers of Various Disorders: A Review

Plenis

Olędzka

Kowalski

et al. 2019

JCM

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Biogenic amines (BAs) are bioactive endogenous compounds which play a significant physiological role in many cell processes like cell proliferation and differentiation, signal transduction and membrane stability. Likewise, they are important in the regulation of body temperature, the increase/decrease of blood pressure or intake of nutrition, as well as in the synthesis of nucleic acids and proteins, hormones and alkaloids. Additionally, it was confirmed that these compounds can be considered as useful biomarkers for the diagnosis, therapy and prognosis of several neuroendocrine and cardiovascular disorders, including neuroendocrine tumours (NET), schizophrenia and Parkinson’s Disease. Due to the fact that BAs are chemically unstable, light-sensitive and possess a high tendency for spontaneous oxidation and decomposition at high pH values, their determination is a real challenge. Moreover, their concentrations in biological matrices are extremely low. These issues make the measurement of BA levels in biological matrices problematic and the application of reliable bioanalytical methods for the extraction and determination of these molecules is needed. This article presents an overview of the most recent trends in the quantification of BAs in human samples with a special focus on liquid chromatography (LC), gas chromatography (GC) and capillary electrophoresis (CE) techniques. Thus, new approaches and technical possibilities applied in these methodologies for the assessment of BA profiles in human samples and the priorities for future research are reported and critically discussed. Moreover, the most important applications of LC, GC and CE in pharmacology, psychology, oncology and clinical endocrinology in the area of the analysis of BAs for the diagnosis, follow-up and monitoring of the therapy of various health disorders are presented and critically evaluated.

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Section: Sample Preparationmentioning

confidence: 99%

Recent Trends in the Quantification of Biogenic Amines in Biofluids as Biomarkers of Various Disorders: A Review

Plenis

Olędzka

Kowalski

et al. 2019

JCM

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“…Among the neurotransmitters, biogenic amines (BA) are of particular interest due to their impact in areas ranging from biomarkers of specific diseases [5][6][7] to quality control of foodstuffs [8,9]. Nitric oxide (NO) is also very important neurotransmitter in the central, peripheral, and enteric nervous systems (ENS) [10,11].…”

Section: Detection Of Neurotransmittersmentioning

confidence: 99%

Red or Blue? Gold Nanoparticles in Colorimetric Sensing

Gaviña¹,

Parra²,

Gil³

et al. 2019

Gold Nanoparticles - Reaching New Heights

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Gold nanoparticles (AuNPs) have been extensively used for the design of colorimetric sensors and probes due to their interesting photophysical properties. In particular, their surface plasmon resonance (SPR) is influenced not only by the size but also by the shape or the properties of the matrix surrounding the nanoparticles. This SPR band is sensitive to the proximity of other nanoparticles, and thus, analyte-triggered aggregation of AuNPs results in an important bathochromic shift of the SPR band and a change in the color of the solution from red to blue due to interparticle surface plasmon coupling. The selectivity of the AuNPs-based sensors toward the different analytes will depend on the recognition properties of the molecules attached to the surface of the nanoparticles. In this chapter, a selection of biologically active molecules has been considered as analytes: neurotransmitters, nerve agents, pesticides, and carboxylates of biological interest.

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“…In particular, the localized surface plasmon resonance (SPR) is influenced by not only the size and shape of nanoparticles but also by the dielectric properties of the environment and the proximity of other nanoparticles [1,2]. Among the neurotransmitters, biogenic selective amines are paid specific attention due to their influence in areas ranging from biomarkers of specific problems or diseases [3][4][5] to quality control of foodstuffs [6,7]. Nitric oxide (NO) is also a very important neurotransmitter in the central, peripheral, and enteric nervous systems (ENS) [8,9].…”

Section: Literature Surveymentioning

confidence: 99%