Methods of deconditioning persisting avoidance: Drugs as adjuncts to response prevention

Taub, J D Sheila; Taylor, Pamela; Smith, Martin; Kelley, Kim L.; Becker, Bruce M.; Reid, Larry D.

doi:10.3758/bf03335301

Cited by 32 publications

(12 citation statements)

References 30 publications

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“…This study, therefore, supports the conclusion derived from similar studies (Kamano, 1973;Taub et al, 1977) that the benzodiazepines are not efftcient adjuncts to RP, particularly when performance after treatment and without drug is the measure of interest. Perhaps previous studies were inadequate because the total RP period was short in relationship to the amount of training and because there was only one session under the influence of drug.…”

Section: Discussionsupporting

confidence: 87%

“…Copyright 1979 Psychonomic Society, Inc. 46 modify persisting avoidance, including the administration of a number of psychotropic agents (Taub, Taylor, Martin, Kelley, Becker, & Reid, 1977). Taub et al (1977) found that many drugs were not effective adjuncts to RP.…”

mentioning

confidence: 99%

“…Taub et al (1977) found that many drugs were not effective adjuncts to RP. Chlordiazepoxide, for example, actually led to more persisting avoidance than placebo.…”

mentioning

confidence: 99%

“…The conclusion reached by Taub et al based on their data and others (e.g., Kamano, 1973) was that giving such drugs to control anxiety/fear/avoidance was not only ineffective but potentially detrimental. Perhaps, however, the Taub et al (1977) procedure, using a single, relatively brief period of RP under the influence of a drug, provided a peculiar test of a drug's potential to modify persisting avoidance. Becker, Magnuson, and Reid (1977) did show that a counterconditioning treatment was effective as an adjunct to RP using the same basic procedure.…”

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confidence: 99%

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Methods of deconditioning persisting avoidance: Diazepam as an adjunct to response prevention

Gorman

Dyak

Reid

1979

Bull. Psychon. Soc.

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Rats were trained to avoid footshock during three daily sessions, 100 trials/session, in an automated one-way avoidance chamber. Subsequent to training, footshock was terminated and the rats' persistence in responding was tabulated. Between training and the test of persisting avoidance, three groups of rats received a response prevention (RP) treatment and one group received no RP. RP consisted of forcing the rats to stay on the once-dangerous grid for 5 min, once a day for 4 days. Two groups received RP under the influence diazepam (25 or 50 mg/kg, p.o.). With respect to persisting avoidance, groups ordered themselves from most to least as: (1) placebo with no RP, (2) high dose of diazepam with RP, (3) low dose of diazepam with RP, and (4) placebo with RP. Because RP with placebo was the most effective treatment, it was concluded that diazepam is inefficient as an adjunctive treatment for overcoming persisting anxiety/fear/avoidance.

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Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

“…Taub et al (1977) found that many drugs were not effective adjuncts to RP. Chlordiazepoxide, for example, actually led to more persisting avoidance than placebo.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Methods of deconditioning persisting avoidance: Diazepam as an adjunct to response prevention

Gorman

Dyak

Reid

1979

Bull. Psychon. Soc.

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“…In one extended series of tests (Taub, Taylor, Smith, Kelley, Becker, & Reid, 1977), rats were given 50 training trials a day on 3 consecutive days, given response prevention under the influence of a dose of a drug, and then tested for persisting avoidance 3 days after their treatment. In these tests, none of the popular psychotropics used to treat irrational anxiety-fear-avoidance in human clients led to a reduction in persisting avoidance.…”

mentioning

confidence: 99%

Methods of deconditioning persisting avoidance: Intracranial stimulation as a counterconditioner

1977

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Rats were fixed with a chronically indwelling electrode for intracranial stimulation (lCS) of the lateral hypothalamus. Subsequent to verification that rats would barpress for ICS, they were trained in an automated one-way avoidance chamber to avoid footshock by climbing to a ledge. After 50 daily training trials on 3 consecutive days, the foots hock was terminated. One of three treatments was then programmed: (a) response prevention (retracting the ledge, forcing the rat to stay on the previously shocking grid), (b) periodic ICS during response prevention, or (c) ICS outside the chamber without response prevention. Three days later, persisting avoidance behavior in the rat was measured. It was concluded that ICS during response prevention was most effective in reducing persisting avoidance, followed by response prevention alone, and finally ICS outside the chamber.

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Failure of a peripheral muscle relaxant (suxomethonium bromide) to increase the efficacy of flooding (response prevention) in rats

Baum

Roy

Leclerc

1985

Behaviour Research and Therapy

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Methods of deconditioning persisting avoidance: Drugs as adjuncts to response prevention

Cited by 32 publications

References 30 publications

Methods of deconditioning persisting avoidance: Diazepam as an adjunct to response prevention

Methods of deconditioning persisting avoidance: Diazepam as an adjunct to response prevention

Methods of deconditioning persisting avoidance: Intracranial stimulation as a counterconditioner

Failure of a peripheral muscle relaxant (suxomethonium bromide) to increase the efficacy of flooding (response prevention) in rats

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