Methods of Determination of Acetamiprid and Its Degradation Products in Soil by Gas Chromatography

Tokieda, Masanori; Ozawa, Michihiro; Gomyo, Takeshi

doi:10.1584/jpestics.24.181

Cited by 15 publications

(13 citation statements)

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“… The proposed metabolic pathways of IMI, IMT, AAP and THI in soil. The brackets denote the hypothetical but not the observed intermediate, as previously reported 6, 27, 33…”

Section: Resultsmentioning

confidence: 93%

“…This was due to the rapid disappearance of AAP in soil with a half‐life of 4.3 days, and no metabolite was detected in HPLC analysis (Figs 1 and 2). Even if, in some cases, AAP could be transformed in soil to IM‐1‐4, a metabolite of the cleavage of N(CH 3 )C(CH 3 )CN linkage, IM‐1‐4 had no insecticidal activity because of loss of the selective cyanoguanidine pharmacophore 27, 28…”

Section: Resultsmentioning

confidence: 99%

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Soil microbial degradation of neonicotinoid insecticides imidacloprid, acetamiprid, thiacloprid and imidaclothiz and its effect on the persistence of bioefficacy against horsebean aphid Aphis craccivora Koch after soil application

Dai

Huang

et al. 2011

Pest Management Science

128

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“… The proposed metabolic pathways of IMI, IMT, AAP and THI in soil. The brackets denote the hypothetical but not the observed intermediate, as previously reported 6, 27, 33…”

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Soil microbial degradation of neonicotinoid insecticides imidacloprid, acetamiprid, thiacloprid and imidaclothiz and its effect on the persistence of bioefficacy against horsebean aphid Aphis craccivora Koch after soil application

Dai

Huang

et al. 2011

Pest Management Science

128

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“…Acetamiprid has been analysed by Gas Chromatography (GC), [5,6] High Performance Liquid Chromatography (HPLC) [7] and by Enzime Linked Inmunosorbent Assay (ELISA) based on monoclonal antibody, [8] but the high water solubility of this pesticide (4200 mg L À1 ) [1] makes more adequate its determination by HPLC than by GC. Therefore, as a consequence of this problematical situation, acetamiprid would be an alternative to these OP pesticides, and it seems interesting to find new simple and rapid methods with enough accuracy and precision to reach possible European MRLs.…”

Section: Marcel Dekker Inc • 270 Madison Avenue • New York Ny 10016mentioning

confidence: 99%

Determination of Acetamiprid by HPLC-Fluorescence With Post-Column Photoderivatization and HPLC-Mass Selective Detection

Vidal

García

Galera

et al. 2002

Journal of Liquid Chromatography & Related Technologies

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Two methods are described for determining the highly polar pesticide acetamiprid in vegetables. Residues are extracted with ethyl acetate and coextratives are removed with a graphitised Carbon-based packing ENVI-carb cartridge. Analysis is performed with goods results, by HPLC with post-column photoderivatization, and fluorescence detection and by HPLC-Electrospray ionisation mass spectrometry. The clean-up step is not necessary in this last case. LODs were 6 mg L À1 for HPLCfluorescence detection using matrix matched standards and 1.5 mg L À1 for HPLC-ES-MS detection. Recovery data were obtained by fortifying vegetable matrix at 0.01, 0.1, and 0.5 mg kg À1 , with recoveries between 65 and 75% for the HPLC-fluorescence and between 72 and 77% for HPLC-ES-MS.

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“…The metabolism of imidacloprid has been studied in mammals,18, 19 insects,20 plants and soils 21–23. The metabolism of acetamiprid has only been studied in plants and soils 24–28. In order to understand the mode of action of acetamiprid in the honeybee, we first characterized the pharmacokinetics of this insecticide following oral exposure to a low dose.…”

Section: Introductionmentioning

confidence: 99%

In vivo metabolic fate of [¹⁴C]‐acetamiprid in six biological compartments of the honeybee, Apis mellifera L

Brunet¹,

Badiou²,

Belzunces³

2005

Pest Management Science

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The in vivo metabolism of acetamiprid was studied in the honeybee, Apis mellifera L. The distribution of acetamiprid and its metabolites was monitored over a 72-h period in six biological compartments: head, thorax, abdomen, haemolymph, midgut and rectum. Honeybees were treated orally with 100 microg [14C]-acetamiprid kg(-1) bee, a dose which is about 1500 times lower than the median lethal dose. After 72 h, only 40% of the total radioactivity was eliminated, suggesting that acetamiprid and its metabolites tended to persist in the honeybee. Acetamiprid was rapidly distributed in all compartments and metabolized. Just after administration, radioactivity was mainly localized in the abdomen and subsequently in the rectum. After 72 h, the maximum amount of radioactivity (about 20% of the ingested dose) was detected again in the abdomen, whereas the lowest level of total radioactivity was detected in the haemolymph. Radioactivity in the head did not exceed 7.6% of total ingested radioactivity. More than 50% of acetamiprid was metabolised in less than 30 min, indicating a very short half-life for the compound. During the first hours, acetamiprid was mainly detected in nicotinic acetylcholine receptor-rich tissues: abdomen, thorax and head. Of the seven metabolites detected, the major ones were 6-choronicotinic acid and an unknown metabolite called U1, which was present mainly in the rectum, the thorax and the head. Our results indicate that the low toxicity of acetamiprid may reflect its rapid metabolism.

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Methods of Determination of Acetamiprid and Its Degradation Products in Soil by Gas Chromatography

Cited by 15 publications

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Soil microbial degradation of neonicotinoid insecticides imidacloprid, acetamiprid, thiacloprid and imidaclothiz and its effect on the persistence of bioefficacy against horsebean aphid Aphis craccivora Koch after soil application

Soil microbial degradation of neonicotinoid insecticides imidacloprid, acetamiprid, thiacloprid and imidaclothiz and its effect on the persistence of bioefficacy against horsebean aphid Aphis craccivora Koch after soil application

Determination of Acetamiprid by HPLC-Fluorescence With Post-Column Photoderivatization and HPLC-Mass Selective Detection

In vivo metabolic fate of [¹⁴C]‐acetamiprid in six biological compartments of the honeybee, Apis mellifera L

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Methods of Determination of Acetamiprid and Its Degradation Products in Soil by Gas Chromatography

Cited by 15 publications

References 0 publications

Soil microbial degradation of neonicotinoid insecticides imidacloprid, acetamiprid, thiacloprid and imidaclothiz and its effect on the persistence of bioefficacy against horsebean aphid Aphis craccivora Koch after soil application

Soil microbial degradation of neonicotinoid insecticides imidacloprid, acetamiprid, thiacloprid and imidaclothiz and its effect on the persistence of bioefficacy against horsebean aphid Aphis craccivora Koch after soil application

Determination of Acetamiprid by HPLC-Fluorescence With Post-Column Photoderivatization and HPLC-Mass Selective Detection

In vivo metabolic fate of [14C]‐acetamiprid in six biological compartments of the honeybee, Apis mellifera L

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In vivo metabolic fate of [¹⁴C]‐acetamiprid in six biological compartments of the honeybee, Apis mellifera L