The purpose of these studies was to determine the possibility of the effect of Polyoxidonium on the accumulation of immunoglobulins and other immunogenic factors in the mammary gland of cows before calving, their isolation in colostrum, as well as the influence of these factors on the state of colostral immunity and the formation of nonspecific resistance in calves after drinking such colostrum. An increase in the number of erythrocytes, leukocytes, due to lymphocytes was noted; the level of total protein, especially the fractions of albumins and γ-globulins, was higher; as well as the hemoglobin level 6 hours after birth in experienced calves compared to control ones.