Methods of Improving Reproductive Parameters  in Sheep and The Major Genes Associated with Prolificacy: A Review

Deac, Alexandru Marius; MUSCĂ, Adriana Sebastiana; AIPĂTIOAIE, Marius Gavril; COŞIER, Viorica; ZĂHAN, Marius

doi:10.15835/10.15835/buasvmcn-asb:2021.0020

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“…The Neuropeptide Y (NPY) gene, mapped on OAR4, has been reported to be associated with the inhibition of LHreleasing hormone in sheep (Malven et al, 1992), whereas the Aurora Kinase C (AURKC) gene has been associated with oocyte maturation and embryo development in goat (Singh et al, 2014). The Guanylate Cyclase 1 Soluble -1157-1161-1165-1169-1697-1701-1704-1735-2830-2834-2838-2842-2845-2849-2853-2880-2884-2888-2892-2895-2899-2903-2907-2911-2915 Subunit Alpha 1 (GUCY1A1), mapped on OAR17, was reported to be associated with litter size in Chinese sheep by Ma et al (2019) and Deac et al (2022). Among the genes found to be associated in literature with disease resistance, the Thiamin Pyrophosphokinase 1 (TPK1), the Brain Abundant Membrane Attached Signal Protein 1 (BASP1) and the Golgin A3 (GOLGA3) genes were found mapped on OAR4, on OAR16 and on OAR17, respectively.…”

Section: Genome-wide Association Studymentioning

confidence: 99%

Investigation of phenotypic, genetic and genomic background of Milk spectra in Sarda dairy sheep

Congiu,

Falchi,

Carta

et al. 2023

J Animal Breeding Genetics

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Aim of this study was to analyse the genetic background of milk Fourier transform infrared (FTIR) spectra in dairy sheep. Individual milk FTIR spectra, with 1060 wavenumbers each, were available for 793 adult Sarda breed ewes genotyped at 45,813 SNP. The absorbance values of each wavenumber was analysed using a linear mixed model that included dim class, parity and lambing month as fixed effects and flock‐test date and animal as random effects. The model was applied to estimate variance components and heritability and to perform a genome‐wide association study for each wavenumber. Average h2 of wavenumbers absorbance was 0.13 ± 0.08, with the largest values observed in the regions associated with the characteristic bonds of carbonylic and methylenic groups of milk fat (h2 = 0.57 at 1724–1728 cm−1; and h2 = 0.34 at 2811–2834 cm−1, respectively). The absorbance values of wavenumbers were moderately correlated with the estimated heritabilities. After the Bonferroni correction, a total of nine markers were found to be significantly associated with 32 different wavenumbers. Of particular interest was the SNP s63269.1, mapped on chromosome 2, that was found to be associated with 27 wavenumbers. Genes previously found to be related to traits of interest (e.g. disease resistance, milk yield and quality, cheese firmness) are located close to the significant SNP. As expected, the heritability estimated for the absorbance of each wavenumbers seems to be associated with the related milk components.

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