Methods of Peptide Synthesis

Wieland, Th.; Determann, Helmut

doi:10.1002/anie.196303581

Cited by 20 publications

(4 citation statements)

References 170 publications

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“…Path B likewise finds analogies in the literature. 6 In view of the relation of this problem to the general phenomenon of intramolecular acylation we have…”

Section: Dehydrationmentioning

confidence: 99%

“…In monochloro compound IV, the C-4 nitro group is only 3.6°out of the plane of the benzene ring7 and in dichloro compound V, the C-4 and C-6 nitro groups are only 37°out of the plane of the benzene ring. 6 The dihedral angle made by the O-N-O plane of the C-4 and C-6 nitro groups with the plane of the benzene ring in VI and VII has not been measured, but it probably does not differ too much (3) J. D. Loudon, J. Chem. Soc., 1525Soc., (1940.…”

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confidence: 99%

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Reduction of Nitroaromatic Compounds with Sodium Borohydride

Kaplan¹

1964

J. Am. Chem. Soc.

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“…Path B likewise finds analogies in the literature. 6 In view of the relation of this problem to the general phenomenon of intramolecular acylation we have…”

Section: Dehydrationmentioning

confidence: 99%

mentioning

confidence: 99%

Reduction of Nitroaromatic Compounds with Sodium Borohydride

Kaplan¹

1964

J. Am. Chem. Soc.

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“…. It was first isolated from the deadly poisonous fungus Amanita phalloides and later it was prepared synthetically. The toxicity of A. phalloides is associated with two distinct class of toxins, amatoxins and phallotoxins.…”

Section: Introductionmentioning

confidence: 99%

Affinity capillary electrophoresis employed for determination of stability constants of antamanide complexes with univalent and divalent cations in methanol

Pangavhane

Makrlík

Ruzza³

et al. 2019

Electrophoresis

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Affinity capillary electrophoresis (ACE) and pressure‐assisted ACE were employed to study the noncovalent molecular interactions of antamanide (AA), cyclic decapeptide from the deadly poisonous fungus Amanita phalloides, with univalent (Li+, Na+, K+, and NH4+) and divalent (Mg2+ and Ca2+) cations in methanol. The strength of these interactions was quantified by the apparent stability constants of the appropriate AA‐cation complexes. The stability constants were calculated using the nonlinear regression analysis of the dependence of the effective electrophoretic mobility of AA on the concentration of the above ions in the BGE (methanolic solution of 20 mM chloroacetic acid, 10 mM Tris, pHMeOH 7.8, containing 0–50 mM concentrations of the above ions added in the form of chlorides). Prior to stability constant calculation, the AA effective mobilities measured at actual temperature inside the capillary and at variable ionic strength of the BGEs were corrected to the values corresponding to the reference temperature of 25°C and to the constant ionic strength of 10 mM. From the above ions, sodium cation interacted with AA moderately strong with the stability constant 362 ± 16 L/mol. K+, Mg2+, and Ca2+ cations formed with AA weak complexes with stability constants in the range 37–31 L/mol decreasing in the order K+ > Ca2+ > Mg2+. No interactions were observed between AA and small Li+ and large NH4+ cations.

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“…Recently, the Staudinger ligation has arisen as a powerful alternative to the "native chemical ligation" approach toward peptide fragments, [16] addressing the inherent limitations associated with the need for a cysteine residue at the site of elaboration. [17] To determine, whether the PPh 3 -catalyzed Staudinger ligation would lead to racemization of chiral aamino acids, we examined the coupling of acids 9 with azido glycinate 2 g [Eq.…”

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confidence: 99%