Methods of preparation of p-nitroacetophenone (review)

Solubility Measurement and Modeling of 1-(3-nitrophenyl)Ethanone and 1-(4-nitrophenyl)Ethenone in Nine Pure Organic Solvents from T = (278.15 to 318.15) K and Mixing Properties of Solutions

“…Zaleplon has a good sedation and hypnosis function, which is prepared by using 1-(3-nitrophenyl) ethanone as raw material, reduction acylation of iron powder (got 3-acetaminoacetophenone), aldol condensation with N , N -dimethylformamide, and then alkylation with iodide and cyclization with 3-amino-4-pyrazolecarbonitrile. , Moreover, its downstream product 1,5-bis­(3-nitroacetophenone) thiocarbohydrazone has good anticancer activities . 1-(4-Nitrophenyl)­ethanone is applied to synthesize chloramphenicol, which is used extensively in medial and veterinary practice for the treatment of bacterial infections. − Due to their potential biological activity, there are many synthetic methods reported. ,− However, the product acquired by nitration method is the isomeric mixtures of 1-(3-nitrophenyl)­ethanone and 1-(4-nitrophenyl)­ethenone, which limits their applications in lots of aspects. With the development of industry, the requirements for product quantity and purity are becoming higher.…”

Solid–Liquid Phase Equilibrium for Ternary Systems of p-Nitroacetophenone plus m-Nitroacetophenone plus Methanol/Toluene/Ethyl Acetate

“…For example, zaleplon prepared through m -nitroacetophenone as a raw material has a worthy hypnosis and sedation purpose. , Additionally, its derivative 1,5-bis­(3-nitroacetophenone) thiocarbohydrazone has anticancer activities − Owing to the potential biological activities of m -nitroacetophenone and m -nitroacetophenone, several preparation approaches have been reported in publications. ,− Nevertheless, the product acquired through nitration is a mixture of isomeric p -nitroacetophenone and m -nitroacetophenone. With the development of the medical industry, the necessity for product purity and quantity is becoming greater and greater.…”