Methods of synthesis of acrolein and its α-substituted derivatives

α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

“…Meanwhile, many years have passed since the publication of the last review devoted to the chemistry of α-functionally substituted acrolein derivatives. Indeed, this review only covered the synthetic approaches to acrolein and its α-substituted analogs developed before 1993 [ 10 ]. There were other survey publications on this topic, in which, however, 2-functionally substituted 2-alkenals were only described partially.…”

A Practical Method for the Synthesis of 2-Alkynylpropenals

“…On the other hand, the multiple functional groups incorporated in these compounds suggest that they should serve as valuable synthetic building blocks in a number of applications. Unfortunately, the anticipated sensitivity of these enynals limits the range of methods potentially applicable for their preparation, and to date the synthetic utility of this class of aldehydes remains unrealized …”

Synthesis and several properties of 2-alkoxy- and 2-alkylthio-3-aryl(hetaryl)propenals

“…Aliphatic 2-alkoxy-and 2-alkylthioalkenals have been synthesized using a number of different protocols. 2,6 The most common procedure involves the aminomethylation of the corresponding alkoxy-or aryloxyacetaldehydes followed by the decomposition of hydrochloride Mannich base. 7 The attempts to prepare 2-alkylthiopropenals by either Mannich reaction 8 or alkylsulfenylchlorination of acrolein with subsequent dehydrochlorination of the adduct 9 almost always result in the isolation of cyclic dimers, namely 2-formyl-2,5-dialkylthio-2,3-dihydro-4Н-pyranes.…”