Methods to assess sensitivity of optical coherence tomography systems

Agrawal, Anant; Pfefer, T. Joshua; Woolliams, Peter; Tomlins, Peter H.; Nehmetallah, George

doi:10.1364/boe.8.000902

Cited by 45 publications

(31 citation statements)

References 21 publications

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“…The fast acquisition speed is achieved by reading out the central 1024 pixels of the spectrometer in 8-tap, 10-bit camera mode (limited by the NI framegrabber). The measured spectrometer sensitivity and roll-off were 83 dB and −9.9 dB/mm (−7.7 dB/mm up to 1 mm depth), following the method reported by Agrawal [ 40 ]. The SLO channel is not active in ‘fast scan’ mode.…”

Section: Methodsmentioning

confidence: 98%

Trans-retinal cellular imaging with multimodal adaptive optics

Liu

Tam

Saeedi

et al. 2018

Biomed. Opt. Express

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Adaptive optics (AO), when coupled to different imaging modalities, has enabled resolution of various cell types across the entire retinal depth in the living human eye. Extraction of information from retinal cells is optimal when their optical properties, structure, and physiology are matched to the unique capabilities of each imaging modality. Despite the earlier success of multimodal AO (mAO) approaches, the full capabilities of the individual imaging modalities were often diminished rather than enhanced when integrated into multimodal platforms. Furthermore, many mAO designs added unnecessary complexity, making clinical translation difficult. In this study, we present a novel mAO system that combines two complementary approaches, scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT), in one instrument using a simplified optical design, flexible alternation of scanning modes, and independent focus control. The mAO system imaging performance was demonstrated by visualization of cells in their mosaic arrangement across the full depth of the retina in three human subjects, including microglia, nerve fiber bundles, retinal ganglion cells and axons, and capillaries in the inner retina and foveal cones, peripheral rods, and retinal pigment epithelial cells in the outer retina. Multimodal AO is a powerful tool to capture the most complete picture of retinal health.

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Section: Methodsmentioning

confidence: 98%

Trans-retinal cellular imaging with multimodal adaptive optics

Liu

Tam

Saeedi

et al. 2018

Biomed. Opt. Express

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“…Figure 4(b) shows the processed one-dimensional intensity distribution indicated with the dashed line in Fig. 4(a) from which the signal-to-noise ratio (SNR) can be estimated to be [25] SNR = 20 log I samp σ bg = 20 log 1904 11.47 = 44.40 dB.…”

Section: Image Processingmentioning

confidence: 99%

“…The incident power on the reflection mirror was estimated to be about 0.01 mW. When the effect of the NDF is taken into account, the maximum available SNR of the system can be estimated to achieve 120.65 dB [25]. Therefore, the sensitivity of the system can be further improved when a camera with higher dynamic range is used.…”

Section: Image Processingmentioning

confidence: 99%

Two dimensional non-scanning transform-free spatial-domain optical coherence tomography

Lin

Chang

Hsu

2019

Biomed. Opt. Express

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A novel optical coherence tomography system that can perform scanless two dimensional imaging without Fourier transform is proposed and demonstrated. In the system, a convex cylindrical mirror generates an extended spatial distribution of optical delay in the reference arm and a cylindrical lens is used to form a focused line beam in the sample arm. A charge-coupled device camera captures the two dimensional tomographic image of a sample in a snapshot manner. Due to its simple configuration and operation, the system is suitable for developing a compact device for tomographic imaging and measurement.

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“…It is commonly based on imaging techniques, such as ultrasound-based elastography [4] and magnetic resonance elastography [5]; they have been widely studied and applied for the diagnosis and evaluation of the treatment responses in many diseases, for example, breast cancer [6], cardiology [7] and liver fibrosis staging [8]. Optical coherence elastography (OCE) stands out with the inherited advantages from optical coherence tomography (OCT), with high resolution in micrometre scale [10] and high sensitivity above 90 dB [11]. Optical coherence elastography (OCE) stands out with the inherited advantages from optical coherence tomography (OCT), with high resolution in micrometre scale [10] and high sensitivity above 90 dB [11].…”

Section: Introductionmentioning

confidence: 99%

“…However, the resolution of ultrasound imaging and MRI systems is relatively low, that limits the application of early tumour detection with a size of 100 μm [9]. Optical coherence elastography (OCE) stands out with the inherited advantages from optical coherence tomography (OCT), with high resolution in micrometre scale [10] and high sensitivity above 90 dB [11]. OCT also offers high displacement sensitivity with the capability to detect deformation in nanometre scale, phase sensitive OCT (PhS-OCT) built by Wang et al [12] could detect deformation in 10 nm; common path Fourier domain OCT established achieved a displacement sensitivity of 0.34 nm [13].…”

Section: Introductionmentioning

confidence: 99%

Optimal stimulation frequency for vibrational optical coherence elastography

Zhang

Wang

et al. 2019

Journal of Biophotonics

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Vibrational optical coherence elastography (OCE) is a promising tool for extracting the mechanical property of soft tissue.Purpose of this study is focusing on settling the optimal frequency range for vibrational OCE with evenly distributed stress filed. A finite element model of 2% agar phantom was built by ANSYS with a vibration stimulation frequency range from 200 to 3000 Hz. Practical experiments were carried out for cross-validation with the same frequencies and sample. Lateral and horizontal stress filed distributions under different frequencies were mathematically evaluated by coefficient of variance and degree of linearity. Results from simulation and practical experiment cross-validated each other and 1000 Hz was set as the maximum ideal frequency for vibrational OCE, while the minimum frequency is set by theoretical calculation with a result of 250 Hz. An ex vivo biological sample was utilised to testify performance of vibrational OCE with excitation frequencies in and out of concluded optimal range, which showed that stiffness was better mapped out in optimal frequency range. K E Y W O R D Smechanical property, optical coherence elastography, optimal frequency, vibration elastography

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Methods to assess sensitivity of optical coherence tomography systems

Cited by 45 publications

References 21 publications

Trans-retinal cellular imaging with multimodal adaptive optics

Trans-retinal cellular imaging with multimodal adaptive optics

Two dimensional non-scanning transform-free spatial-domain optical coherence tomography

Optimal stimulation frequency for vibrational optical coherence elastography

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