Methods to Supplement the Mineral-Containing Proteins

Zhou, Ting

doi:10.1007/978-981-10-3596-8_7

Cited by 1 publication

(1 citation statement)

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“…Phytoferritin architecturally resembles animal ferritin, although animal ferritin consists of heavy (H‐) and light (L) MW subunits, the latter of which is absent in phytoferritin (Zhao, 2010; Zielińska‐Dawidziak, 2015). Phytoferritin is known to have one to three H‐ subunits (Zhou, 2017), which shares approximately 40% sequence identity with animal ferritin (Zhao, 2010), but is subject to pronounced inter‐species variation in its ratio and AA sequence (Roschzttardtz et al., 2013). These H‐ subunits are precursors to a specific domain extension peptide (EP) on the protein exterior that stabilizes its oligomeric conformation (Li et al., 2009; Yang, Zhou, Sun, Gao, & Xu, 2015).…”

Section: Ligands In Relation To Bioavailabilitymentioning

confidence: 99%

Opportunities for plant‐derived enhancers for iron, zinc, and calcium bioavailability: A review

Zhang

Stockmann

et al. 2020

Comp Rev Food Sci Food Safe

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Understanding of the mechanism of interactions between dietary elements, their salts, and complexing/binding ligands is vital to manage both deficiency and toxicity associated with essential element bioavailability. Numerous mineral ligands are found in both animal and plant foods and are known to exert bioactivity via element chelation resulting in modulation of antioxidant capacity or micobiome metabolism among other physiological outcomes. However, little is explored in the context of dietary mineral ligands and element bioavailability enhancement, particularly with respect to ligands from plant‐derived food sources. This review highlights a novel perspective to consider various plant macro/micronutrients as prospective bioavailability enhancing ligands of three essential elements (Fe, Zn, and Ca). We also delineate the molecular mechanisms of the ligand‐binding interactions underlying mineral bioaccessibility at the luminal level. We conclude that despite current understandings of some of the structure–activity relationships associated with strong mineral–ligand binding, the physiological links between ligands as element carriers and uptake at targeted sites throughout the gastrointestinal (GI) tract still require more research. The binding behavior of potential ligands in the human diet should be further elucidated and validated using pharmacokinetic approaches and GI models.

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