Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis

Wu, Qiuyu; Chen, Xiangjie; Qiao, Caixia; Cao, Xinhua; Du, Qian; Yuan, Yukang; Zuo, Yibo; Miao, Ying; Zheng, Zhijin; Zhang, Tingting; Zang, Lichao; Yang, Xinyu; Shi, Weifeng; Xie, Zhijun; Xu, Yang; Wu, Depei; Wen, Chengping; Zheng, Hui

doi:10.1016/j.intimp.2022.109595

Cited by 4 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, polyubiquitination of TRAF2, TRAF6, RIP-1 and NEMO activated TAK1 complex, which in turn is associate with IKK activation, ultimately leading to chronic joint damage in a patient of RA (144). Methotrexate, used for the treatment of RA, inhibits the K48-linked polyubiquitination of Numb and promotes Notch-1 ubiquitination, thus restricting the expression of Notch-1 (145). Therefore, ubiquitination of Notch signaling may be related to angiogenesis.…”

Section: The Regulation Of Notch Signaling During Angiogenesis By Ptm...mentioning

confidence: 99%

The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials

Zhao,

He,

Zhao

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Angiogenesis plays a key role in the pathological process of inflammation and invasion of the synovium, and primarily drives the progression of rheumatoid arthritis (RA). Recent studies have demonstrated that the Notch signaling may represent a new therapeutic target of RA. Although the Notch signaling has been implicated in the M1 polarization of macrophages and the differentiation of lymphocytes, little is known about its role in angiogenesis in RA. In this review, we discourse the unique roles of stromal cells and adipokines in the angiogenic progression of RA, and investigate how epigenetic regulation of the Notch signaling influences angiogenesis in RA. We also discuss the interaction of the Notch-HIF signaling in RA’s angiogenesis and the potential strategies targeting the Notch signaling to improve the treatment outcomes of RA. Taken together, we further suggest new insights into future research regarding the challenges in the therapeutic strategies of RA.

show abstract

Section: The Regulation Of Notch Signaling During Angiogenesis By Ptm...mentioning

confidence: 99%