Methotrexate

The combination of calcipotriol and methotrexate compared with methotrexate and vehicle in psoriasis: results of a multicentre placebo-controlled randomized trial

“…In a recent survey of patients in the Dutch Psoriasis Association, 68% of the patients were shown to use combination treatment 13 . Many patients on MTX are often so well managed by the drug that they discontinue their topical therapy 14 . Topical therapy, however, should generally be encouraged to help keep the MTX dose as low as possible.…”

The value of amino-terminal propeptide of type III procollagen in routine screening for methotrexate-induced liver fibrosis: a 10-year follow-up

“…Most of these have previously been reviewed and found not sufficiently reliable for screening for MTX‐induced liver damage 11,17 . More recently, however, in a new review, both PIIINP and dynamic hepatic scintigraphy have been proposed to be suitable, thereby allowing lengthening of liver biopsy intervals 18 …”