Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis

Oak, Jyotsna; Nadkarni, Mandar; Shetty, Archana; Sardar, Shefali; Kulkarni, Bijal

doi:10.1007/s12262-021-02754-w

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Several studies suggest that the disease will improve by itself through Observation alone [ 29 , 30 ]. Some other studies consider conservative treatments the most effective treatment with the lowest recurrence rate [ 45 , 55 , 56 , 70 ], while others find surgery the most appropriate treatment [ 1 , 60 , 62 , 65 ]. Some studies believe that a combination of conservative and surgical therapy should be administered to decrease the recurrence rate [ 22 , 42 , 59 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Sarmadian,

Safi,

Sarmadian

et al. 2024

Eur J Med Res

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Background Granulomatous mastitis (GM) is a rare, benign, inflammatory breast disease with an unknown etiology that predominantly affects women of reproductive age. The definitive treatment of GM is currently controversial; an appropriate therapeutic strategy has yet to be identified, and the disease’s high recurrence rate remains. This study aims to determine the recurrence rate for each GM treatment strategy to identify the most appropriate treatment modality. Methods The search for relevant articles was undertaken using three international databases, including Medline, Scopus, and Web of Science. Articles published in English until the end of 2021 evaluating the recurrence rate of GM were included. Using Stata 13.0, the pooled incidence and 95% confidence interval (CI) for the recurrence rate were determined. Results Sixty-five eligible studies were included in our study. The recurrence rates of systemic steroid use, topical steroid use, antibiotic use, methotrexate use, observation, drainage, excision, antibiotic use and surgery, steroid use and surgery, antibiotic and steroid use, methotrexate and steroid use were 24% (95% CI: 21–27%), 11% (95% CI: 6–21%), 18% (95% CI: 14–22%), 13% (95% CI: 7–22%), 11% (95% CI: 7–17%), 65% (95% CI: 50–78%), 13% (95% CI: 10–16%), 23% (95% CI: 14–36%), 7% (95% CI: 5–11%), 11% (95% CI: 6–18%), and 4% (95% CI: 2–8%), respectively. Drainage had the highest recurrence rate, while combined methotrexate and steroid treatment had the lowest rate. Conclusion The optimal treatment strategy for GM depends on the disease’s severity, consequences, and the patient's features. The study results indicate that combination therapy is preferable for minimizing the risk of relapse and reducing treatment complications.

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Section: Discussionmentioning

confidence: 99%

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Sarmadian,

Safi,

Sarmadian

et al. 2024

Eur J Med Res

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“…Recent studies (130,131) have shown that methotrexate (MTX) is effective in the treatment of GLM. Experts agree that methotrexate, an immunosuppressant, should be used for non-corticosteroids sensitive GLM (19,132).…”

Section: Othersmentioning

confidence: 99%

Identification of periductal mastitis and granulomatous lobular mastitis: a literature review

Jiao¹,

Chang²,

Jiang³

et al. 2023

Ann Transl Med

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Background and Objective: Non-puerperal mastitis (NPM) is a breast disease with poor clinical manifestations, which seriously affects women's health and quality of life. Due to the low incidence rate of the disease and the paucity of related research, there is much misdiagnosis and mis-management of periductal mastitis (PDM) and granulomatous lobular mastitis (GLM). Therefore, understanding the differences between PDM and GLM, in terms of etiology and clinical manifestations, is crucial for patient treatment and prognosis. At the same time, choosing different treatment methods may not achieve the best treatment effect, so the appropriate treatment method can often reduce the patient's pain and reduce the recurrence of the patient's disease. Methods:The PubMed database was searched for articles published from 1 January 1990 to 16 June 2022 using the following search terms: "non-puerperal mastitis", "periductal mastitis", "granulomatous lobular mastitis", "mammary duct ectasia", "idiopathic granulomatous mastitis", "plasma cell mastitis", and "identification". The key findings of the related literatures were analyzed and summarized.

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Idiopathic granulomatous mastitis and cystic neutrophilic granulomatous mastitis: two sides of the same coin or distinct entities?

Aljawder

et al. 2023

Pathology

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Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis

Cited by 6 publications

References 23 publications

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Identification of periductal mastitis and granulomatous lobular mastitis: a literature review

Idiopathic granulomatous mastitis and cystic neutrophilic granulomatous mastitis: two sides of the same coin or distinct entities?

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