Methotrexate‐induced eruptive lentiginosis in resolving psoriasis: a phenomenon possibly dependent on cytokine modulation

Singh, Sanjay; Beniwal, Ranjana

doi:10.1111/ced.13968

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…Since then, several publications have expanded the phenomenon of eruptive lentiginosis at sites of resolving psoriatic disease to include patients receiving biologic therapies, including inhibitors of TNF-alpha (adalimumab [14,15 ▪ ], etanercept [16–18], infliximab [19,20]), IL-12 and IL-23 (ustekinumab [21], guselkumab [22]), as well as PDE-4 (apremilast [23,24]) and methotrexate [25]). Although some of the patients had received other immunosuppressive systemic therapies, such as cyclosporine, the temporal association of the onset of ILIAD in these cases strongly suggested a role for these biologics in triggering or accelerating the onset of the phenomenon.…”

Section: Psoriasismentioning

confidence: 99%

Odyssey toward an understanding of acquired postinflammatory lentiginosis

Yan¹

2021

Current Opinion in Pediatrics

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Purpose of review Acquired postinflammatory lentiginosis is a phenomenon that has been previously termed ‘induction of lentiginosis in assorted dermatoses’ or the ILIAD phenomenon. Recent findings Although some cases have been described as arising exclusively in those who applied topical calcineurin inhibitors (TCIs), other patients have presented with similar findings in other nonatopic disorders (contact dermatitis, psoriasis, lichen planus, focal dermal hypoplasia), and without antecedent use of TCIs. Summary Inflammatory skin disorders can produce localized areas of cutaneous lentiginosis, particularly as the inflammation retreats in response to treatment. This post-inflammatory lentiginosis or ILIAD phenomenon may be potentiated by use of topical and systemic anti-inflammatory medications, including TCIs, topical corticosteroids, methotrexate, and systemic biologic agents. Although this phenomenon has not been associated with melanocytic neoplasia, ongoing periodic monitoring for dysplastic changes is reasonable.

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