Methotrexate-loaded chitosan nanogels as ‘Trojan Horses’ for drug delivery to brain: Preparation and in vitro/in vivo characterization

Azadi, Amir; Hamidi, Mehrdad; Rouini, Mohammad-Reza

doi:10.1016/j.ijbiomac.2013.10.004

Cited by 109 publications

(53 citation statements)

References 24 publications

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“…This study provides valuable evidence for the practicable use of the Weibull model in drug release phenomena from swellable polymeric nanoparticles. Likely there are also several studies have experimentally investigated that, the release data from swellable polymeric nanoparticles fit best with the weibull model (Yang et al, 2000;Adibkia et al, 2007;Aksungur et al, 2011;Ji et al, 2011;Bei et al, 2012;Azadi et al, 2013;Sun et al, 2014;Liu et al, 2015;Ashrafi and Azadi, 2016;Jafari-Aghdam et al, 2016). Among the studied models, Weibull is regarded as a favorable model which includes parameters that are sensitive to ranges of release profile.…”

Section: Resultsmentioning

confidence: 92%

“…Currently many materials such as polymers, lipids, proteins, carbons, and inorganic metals are under investigation for drug delivery (Yoon et al, 2013). To improve the delivery systems, several types of nanoparticulate systems including polymeric nanoparticles (Hamidi et al, 2011;Hamidi et al, 2012;Azadi et al, 2015), polymeric micelles, solid nanoparticles, lipid-based nanoparticles, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugate (LDC) , nanoliposomes (Azadi and Ashrafi, 2016), inorganic nanoparticles, dendrimers, magnetic nanoparticles, Ferrofluids, and quantum dots have been introduced and investigated previously . Among the various types of nanocarriers, polymeric nanoparticles which are classified to swellable and non-swellable ones, have been considered as promising devices in controlled drug release systems.…”

Section: Introductionmentioning

confidence: 99%

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Mathematical modeling of drug release from swellable polymeric nanoparticles

2017

J App Pharma Sci

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This study aims to provide a comparative mathematical analysis of drug release from swellable polymeric delivery systems to find a general model applicable to multi-mechanistic release. Drug release data from various swellable polymeric nanoparticles extracted from the literatures were applied to the eight conventional models. Coefficient of determination (R 2 ) and absolute percent error (E%) were calculated for each set as well as the overall error (OE), the number of error (NE) and the akaike information criterion (AIC) for all sets. The model has the highest R 2 and the number of the error, as well as both the lowest overall error (OE) and the akaike information criterion, was considered as the best one. Among the models Weibull (W) model produced R 2 and OE values of 0.93 and 8.79, respectively. Also, the AIC value and the number of errors less than 5% for the model was -34.93 and 46.15% of a total number of data sets respectively. Mathematical modeling of drug release from a carrier is often attempted to recognize the main determinants of the drug release rate from the carrier with the final goal of the identification of the ideal set of conditions leading to the desired release profile in vivo.

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Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of drug release from swellable polymeric nanoparticles

2017

J App Pharma Sci

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“…In between these two processes (0.43 < n < 0.85), an anomalous release mechanism would take place where the diffusion and polymer swelling processes are coupled (Azadi et al, 2013;Hsiao et al, 2012). The values of n in pH 1.2 and 4.5 were 0.37 and 0.34 (Table 3), respectively, suggesting that the in vitro release was rather well controlled by a Fickian release mechanism.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Preparation and evaluation of chitosan-based nanogels/gels for oral delivery of myricetin

Yao

Xia

Wang

et al. 2016

European Journal of Pharmaceutical Sciences

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“…This indicates that nanogels can be utilized for drug delivery into the CNS, due to their efficiency in crossing the BBB effectively. 70 Another hurdle for drug delivery into the CNS is the efflux pumps that actively transport the drug outside the cells. The P-glycoprotein (P-gp), having several substrates, is one of the efflux pumps for the drugs delivered into the brain cells.…”

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confidence: 99%

Regenerative nanomedicine: current perspectives and future directions

Chaudhury¹,

Kumar²,

Kandasamy³

et al. 2014

IJN

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Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.

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Methotrexate-loaded chitosan nanogels as ‘Trojan Horses’ for drug delivery to brain: Preparation and in vitro/in vivo characterization

Cited by 109 publications

References 24 publications

Mathematical modeling of drug release from swellable polymeric nanoparticles

Mathematical modeling of drug release from swellable polymeric nanoparticles

Preparation and evaluation of chitosan-based nanogels/gels for oral delivery of myricetin

Regenerative nanomedicine: current perspectives and future directions

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