2024
DOI: 10.22146/ijc.88495
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Methotrexate-Polymer Nanocomposites for Targeted Pulmonary Drug Delivery

Aseel Khaled Mohammad AL-Sarayrah,
Samer Hasan Hussein-Al-Ali,
Mike Khalil Haddad
et al.

Abstract: Nanocomposite formulation is a suitable technology that enables the development of successful dry powder inhalers. The methotrexate (MTX) and polyamide-disulfide (polymer) were used as a model to form MTX-polymer nanocomposites. Different amounts of the independent variable, MTX (0.025 and 0.050 g), polymer (0.05 and 0.01 g), pH (6.7 and 11.3), and across-linker ferric chloride (FeCl3) (0.05 and 0.10 g) were used. The loading efficiency and particle size were dependent variables. The optimized formula can be o… Show more

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