Methoxy-Monobenzoylmethane Protects Skin from UV-Induced Damages in a Randomized, Placebo Controlled, Double-Blinded Human In Vivo Study and Prevents Signs of Inflammation While Improving the Skin Barrier

Termer, Michael; Jaeger, Axel; Carola, Christophe; Salazar, Andrew; Keck, Cornelia M.; Kolmar, Harald; Hagen, Jörg von

doi:10.1007/s13555-021-00652-3

Cited by 3 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin photoaging is a complicated process in which skin changes are caused by persistent ultraviolet (UV) exposure [1][2][3]. Epidemiological studies and surveys have shown that skin photoaging contributes to the development of numerous skin disorders and skin tumors [4,5]. Public health concerns regarding sun exposure on the skin have grown substantially in recent years as people recognize photoaging damages their health and beauty.…”

Section: Introductionmentioning

confidence: 99%

Needle-Free Injection of Metformin Ameliorates Skin Photoaging Through Inhibition of Ferroptosis and Oxidative Stress

Zhang,

Qin,

Zhang

et al. 2024

Discovery Medicine

View full text Add to dashboard Cite

Background: Skin photoaging is a complex process of skin aging caused by continuous exposure to ultraviolet (UV) radiation through oxidative stress and other pathways, yet effective treatments are scarce. Metformin is a drug with both anti-senescence and antioxidant functions; however, there are fewer studies on photoaging. The study aimed to investigate the role of needlefree injection of metformin in alleviating ultraviolet radiation B (UVB) induced skin photoaging, and to explore the mechanisms through which metformin alleviates fibroblast photoaging by inhibiting ferroptosis and oxidative stress. Methods: In our study, we initially performed bioinformatic analysis on the gene expression profile (GSE38308), and our RNA sequencing (RNA-Seq) found that photoaging is associated with ferroptosis. We investigated the potential skin-protective mechanism of metformin by utilizing a UVB-induced rat skin photoaging model and human skin fibroblasts (HSF) treated with UVB. For in vitro experiments, cellular senescence was detected using SA-β-galactosidase staining and p16 in western blot. Ferroptosis and oxidative stress were assessed via western blot (glutathione Peroxidase 4 (GPX4) and nuclear factor erythroid-2-related factor 2 (Nrf2)), reactive oxygen species (ROS) levels, transmission electron microscope, Lillie's staining, and immunofluorescence staining. During in vivo experiments, metformin was administered by needle-free jet injectors injected into the backs of rats. The effectiveness of metformin was detected using the Masson staining and western blot. Results: We found that the ferroptosis pathway was closely associated with photoaging through bioinformatics analysis. In the UVB-induced photoaging HSF cells, treatment with metformin exhibits the following effects: a reduction in blue-stained granules in SA-β-galactosidase staining and a decrease in the expression of p16, indicating a reduction in cellular senescence. Moreover, metformin leads to decreased ROS levels and increased expression of the oxidative stress-related protein Nrf2, suggesting inhibition of oxidative stress within the cells. Additionally, metformin results in an elevation of GPX4 expression, a decrease in blue-stained granules in Lillie's staining, and a reduction in ferroptosis-associated mitochondrial damage, indicating a decline in ferroptosis. Needle-free injection of metformin could directly achieve therapeutic effects by affecting HSF cells in the dermis. The needle-free injection of metformin treatment effectively improved the photoaging skin in rats compared to the photoaging group, ameliorated oxidative stress, and reduced ferroptosis. Conclusions: Our data highlights a novel needle-free injection of metformin that improves photoaging and has good therapeutic potential.

show abstract

Section: Introductionmentioning

confidence: 99%

Needle-Free Injection of Metformin Ameliorates Skin Photoaging Through Inhibition of Ferroptosis and Oxidative Stress

Zhang,

Qin,

Zhang

et al. 2024

Discovery Medicine

View full text Add to dashboard Cite

show abstract

Sunscreen Challenges: Stability, Systemic Absorption, and Environmental Concerns

Rajan

2024

Sunscreens for Skin of Color

View full text Add to dashboard Cite

Metformin Ameliorated Skin Photoaging by Inhibiting Ferroptosis Through Regulating the Nrf2/Ho-1/Gpx4 Pathway

Zhang,

Qin,

Zhang

et al. 2023

Preprint

View full text Add to dashboard Cite

Methoxy-Monobenzoylmethane Protects Skin from UV-Induced Damages in a Randomized, Placebo Controlled, Double-Blinded Human In Vivo Study and Prevents Signs of Inflammation While Improving the Skin Barrier

Abstract: Introduction: Sun protection is important in skin care and requires special attention as inefficient protection might trigger skin pathologies including polymorphic light eruption (PLE).

Cited by 3 publications

References 41 publications

Needle-Free Injection of Metformin Ameliorates Skin Photoaging Through Inhibition of Ferroptosis and Oxidative Stress

Needle-Free Injection of Metformin Ameliorates Skin Photoaging Through Inhibition of Ferroptosis and Oxidative Stress

Sunscreen Challenges: Stability, Systemic Absorption, and Environmental Concerns

Metformin Ameliorated Skin Photoaging by Inhibiting Ferroptosis Through Regulating the Nrf2/Ho-1/Gpx4 Pathway

Contact Info

Product

Resources

About