Methoxyflurane Analgesia for Office Surgery

Lewis, Leonard A.

doi:10.1111/j.1524-4725.1984.tb01191.x

Cited by 8 publications

(5 citation statements)

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“…This technique was used effectively and safely in obstetrics5 – 7 and postoperative analgesia,8 9 for analgesia during burns-dressing changes,10 11 in the prehospital setting (Komesaroff, unpublished data; 1979), and for minor painful injuries12 or surgical procedures 13. In Australia, methoxyflurane has been used for pain relief in sub-anaesthetic doses for 33 years, and in combination with the drug delivery system Penthrox inhaler (Medical Developments International) for the last 17 years.…”

Section: Introductionmentioning

confidence: 99%

STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain

et al. 2014

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ObjectiveTo evaluate the short-term efficacy and safety of methoxyflurane for the treatment of acute pain in patients presenting to an emergency department (ED) with minor trauma.MethodsSTOP! was a randomised, double-blind, multicentre, placebo-controlled study conducted at six sites in the UK. A total of 300 patients, 90 of whom were adolescent patients (age 12–17 years), were randomised 150:150 to receive either methoxyflurane via a Penthrox inhaler or placebo. The primary end point of the study was the change in pain intensity as measured using the visual analogue scale (VAS) from baseline to 5, 10, 15 and 20 min after the start of study drug inhalation. Patients were supplied with one inhaler containing 3 mL methoxyflurane or 5 mL placebo after enrolment and initial assessments. Age group (adolescent/adult) and baseline VAS score were controlled for in the statistical analyses.ResultsA total of 149 patients received methoxyflurane, and 149 patients received placebo. Demographic and baseline characteristics were comparable between the groups. Methoxyflurane reduced pain severity significantly more than placebo (p<0.0001) at all time points tested, with the greatest estimated treatment effect of −18.5 mm (adjusted change from baseline) seen at 15 min after the start of treatment. Methoxyflurane was well tolerated, with the majority of adverse reactions being mild, transient and in line with anticipated pharmacological action.ConclusionThe results of this study suggest that methoxyflurane administered via the Penthrox inhaler is an efficacious, safe, and rapidly acting analgesic.Trial registration number:NCT01420159.

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Section: Introductionmentioning

confidence: 99%

STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain

et al. 2014

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“…Nitrous oxide/ oxygen mixtures were used widely in the United Kingdom and were later introduced to prehospital care by Baskettin 1969. (13) Methoxyflourane has been used with a self-administered "whistle" apparatus, providing analge-sia that appears to be of a slower onset and longer duration than nitrous oxide/oxygen (28,29). The advantages of the inhalational route readily are apparent-ease of administration, rapid onset, short duration.…”

Section: Inhalational Agentsmentioning

confidence: 99%

Analgesia in the Field

Stewart

1989

Prehosp. Disaster med.

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Emergency Medical Services and the care of patients in the field have taken giant steps forward over the past decade. Born of the desire of physicians to influence the mortality rates of sudden cardiac death in the community, systems of advanced life support have taken root in the urban centers in the United Kingdom, Australia, the United States, and other countries (1-3). Although originally largely designed around the concept of “mobile coronary care,” these systems soon were deluged with calls for help from all sectors of the community, and faced a variety of medical problems. As trauma gradually became recognized for the killer and maimer of young lives that it is, regional programs of trauma care were developed in the United States and led gradually to the expansion of prehospital and interhospital transport systems in which critically injured patients were being moved about, often over long distances. The growth of emergency medicine as a specialty in its own right has encouraged the study and improvement of systems of disaster and mass casualty management.Although the focus of these efforts has been largely the overall reduction of death and disability in critically ill or injured patients, controversy continues around not only the extent of field intervention but also the influence of our efforts on the outcome of these patients (4, 5). The importance of particular interventions such as intravenous line placement, administration of certain medications, the use of the pneumatic anti-shock garment, and other sacred cows of prehospital care, all have been questioned of late (6, 7).

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“…The predominant use of this device over the past 30 years in Australia has been in prehospital transfer of patients by ambulance or following acute injury such as in sport 5 6. Other reported applications of MEOF include for burns dressings,7 obstetrics8 9 and minor office procedures 10…”

Section: Introductionmentioning

confidence: 99%

A randomised, double-blind, placebo-controlled study to assess the safety and efficacy of methoxyflurane for procedural pain of a bone marrow biopsy

Westerman

Milner

Bressel

et al. 2013

BMJ Support Palliat Care

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Methoxyflurane Analgesia for Office Surgery

Abstract: The use of methoxyflurane as a preoperative analgesic is discussed as an inexpensive and safe method for use in office surgery.

Cited by 8 publications

References 0 publications

STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain

STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain

Analgesia in the Field

A randomised, double-blind, placebo-controlled study to assess the safety and efficacy of methoxyflurane for procedural pain of a bone marrow biopsy

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