Methyl 1-prop-2-yn-1-yl-1H-indole-5-carboxylate

Abstract

n/

Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds

“…As the acetylenic building blocks, N-propargyl-substituted 5-methoxyindole (1a) [9], 5-bromoindole (1b), methyl indole-5-carboxylate (1c) [16], and indoline (1d) [17] were employed. In all cases, bis(triphenylphosphine)palladium(II)dichloride and copper(I)iodide were used as catalysts, and the reactions were run in tetrahydrofuran/triethylamine under an argon atmosphere at room temperature (except for 3-bromoisoquinoline: reflux temperature) with TLC monitoring.…”