Methyl inosine monophosphate: A potential immunotherapeutic for early human immunodeficiency virus (HIV) infection

Hadden, John W.; Ongrádi, J; Specter, Steven; Nelson, Robert P.; Sosa, Marina; Monell, Craig R.; Strand, Mette; Giner-Sorolla, A.; Hadden, Elba M.

doi:10.1016/0192-0561(92)90116-3

Cited by 15 publications

(2 citation statements)

References 14 publications

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“…fMethylinosine monophosphate, a purine derivative prepared from D-ribose, was shown to attenuate HIVinduced immunosuppression (Hadden et al 1992). Modi®ed nucleoside antiviral and anticancer agents, such as neplanocin-A (Hill et al 1994), formycin, pyrazofurin (Rycroft et al 1995), and analoges of their key intermediates (Gallos et al 1994a), have all been enantioselectively synthesized from D-ribose.…”

Section: Applications Of D-ribosementioning

confidence: 99%

Production of d -ribose by fermentation

Wulf

Vandamme

1997

Applied Microbiology and Biotechnology

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The production of D-ribose by fermentation has received much attention lately, possibly because of the use of this pentose to synthesize antiviral and anticancer drugs. This review briefly outlines the methods that have been used to synthesize D-ribose since it was identified in yeast RNA, and focuses in particular on the latest developments in D-ribose fermentation, which have led to D-ribose yields that exceed 90 g/1. Furthermore, the various transketolase-deficient D-ribose-producing mutants that are used, and the biochemical and genetic rationales applied to select them or to enhance their D-ribose productivities, are dealt with. Attention is also drawn to the unusual pleiotropic characteristics of the mutant strains, as well as to the industrial and academic applications of D-ribose.

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Section: Applications Of D-ribosementioning

confidence: 99%

Production of d -ribose by fermentation

Wulf

Vandamme

1997

Applied Microbiology and Biotechnology

View full text Add to dashboard Cite

show abstract

“…Methyl inosine monophosphate, a new purine derivative prepared from D-ribose, is under preclinical development, as it attenuates HIV-induced immunosuppression (Hadden et al, 1992). Modified nucleoside antiviral and anticancer agents such as neplanocin-A (Hill et al, 1994), formycin and pyrazofurin (Rycroft et al, 1995), as well as some analogues of their key intermediates (Gallos et al, 1994a), have all been enantioselectively synthesized from D-ribose.…”

Section: Applications Of O-ribosementioning

confidence: 99%