Methyl Jasmonate Ameliorates Testosterone Propionate-induced Prostatic Hyperplasia in Castrated Wistar Rats

Akanni, Olubukola; Abiola, Olusoji John; Adaramoye, Oluwatosin A.

doi:10.1002/ptr.5778

Cited by 11 publications

(7 citation statements)

References 69 publications

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“…PSA Content. At the end of the experiment, blood samples were collected under anesthesia directly from the heart for the evaluation of free prostate-specific antigen (PSA) with the PSA ELISA Kit [65].…”

Section: Glutathione (Gsh) Glutathione (Gsh) Measurementmentioning

confidence: 99%

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Akbari

Azadbakht

Gaurav

et al. 2022

Advances in Urology

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Benign prostatic hyperplasia (BPH) is a common disease that affects elderly men with various complications. This study evaluates the effects of an Iranian traditional herbal medicine “Atrifil and Oshagh gum” on BPH in male Wistar rats. Atrifil is a combination of three medicinal plants: Emblica officinalis Gaertn, Terminalia chebula Retz, and Terminalia bellerica Retz” extracts, and Oshagh gum is Dorema ammoniacum D. Dono gum. In this study, 30 male Wistar rats were divided into five groups: normal control, disease, finasteride, and extract with 300 and 600 mg/kg groups. The extract is a combination of hydroalcoholic Atrifil extract and Oshagh gum. All groups received intramuscular testosterone enanthate to induce BPH except the normal control group. On the twenty-eighth day, prostate glands were separated. Histopathological changes were observed. Furthermore, the prostate-specific antigen (PSA) and prostate weights were measured. The binding propensities of finasteride, equol, and flavonoids present in this extract such as quercetin, rutin, and kaempferol for 5α-reductase, estrogen receptor alpha and beta, and estrogen-related receptor gamma were assessed using in silico docking approach. Histopathological evaluation, biochemical parameter, and PSA level results indicated significant inhibition of accruing and progression of BPH in groups treated with 600 mg/kg extract ( p < 0.01 ). Furthermore, molecular docking showed that rutin had a high affinity to bind the receptors 5α-reductase, estrogen receptor beta, and estrogen-related receptor gamma even more than finasteride, and on average, quercetin had a higher affinity to all these receptors. In the end, it can be concluded that Atrifil and Oshagh gum is effective in preventing BPH.

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Section: Glutathione (Gsh) Glutathione (Gsh) Measurementmentioning

confidence: 99%

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Akbari

Azadbakht

Gaurav

et al. 2022

Advances in Urology

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“…6 rats did not receive TE and just received IM corn oil injection as the normal group (vehicle). Standard medicine group received intramuscular TE and 10 mg/kg body weight finasteride through daily gavage [25]. The design of the experimental procedure used in the study is shown in Table 1.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…After anesthetizing the rats, blood samples were collected from their hearts and sent to an associate laboratory to evaluate free prostate specific antigen (PSA) in the blood using the PSA ELISA kit [25].…”

Section: Psa Contentmentioning

confidence: 99%

Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats

Akbari

Azadbakht

Megha³

et al. 2021

Afr J Urol

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Background Benign prostatic hyperplasia (BPH) is a common disease which causes various health problems for elderly men such as urinary retention, recurring urinary tract infection and bladder stones. The aim of this study is to evaluate the therapeutic effects of Juniperus communis L. seed extract (JCS) on BPH in male Wistar rats. Methods To this end, 30 rats were divided into 5 groups (N = 6): group 1 (vehicle), group 2 (disease control), group 3 (standard medicine; 10 mg/kg finasteride), and groups 4 and 5 were treated with 300 mg/kg and 600 mg/kg of the hydroalcoholic JCS seed extract, respectively. Groups 2, 3, 4 and 5 received testosterone enanthate to induce prostatic hyperplasia. At the end of experimental period (28 days), prostate glands were cut off under anesthesia. Histopathological examination was done and biochemical parameters such as Malondialdehyde, Glutathione and protein carbonyl were also measured. Their body weights were also observed during the study. At the end of the experiment, prostate weights and prostate specific antigen (PSA) levels were measured. Prostate index, inhibition prostate weight and inhibition prostate index were also calculated. Results Both histopathological examination and biochemical parameter results showed significant improvements in rats treated with finasteride and 600 mg/kg JCS extract (p < 0.01). In addition, PSA levels showed significant decrease in comparison with the disease group. But acute toxicity test indicated that using JCS extract resulted in an increase in liver enzymes (ALP, LDH, SGOT, SGPT). As a result, the extract should be used with caution. Conclusions Oral administration of JCS extract is effective on preventing testosterone-induced benign prostatic hyperplasia.

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“…The use of these two classes of medications is limited because of their adverse effects, including decreased libido, ejaculatory dysfunction and upper respiratory tract infection (Bullock & Andriole, 2006 ). Therefore, alternative medicines for the treatment of BPH are being developed continuously (Akanni et al., 2017 ; Ammar et al., 2015 ; Jena et al., 2016 ; Kim et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats

Seo

Shin

Nam

et al. 2021

Food Science & Nutrition

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Methyl Jasmonate Ameliorates Testosterone Propionate-induced Prostatic Hyperplasia in Castrated Wistar Rats

Cited by 11 publications

References 69 publications

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Evaluation of the Therapeutic Effect of the Traditional Herbal Medicine Atrifil and Oshagh Gum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats

Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats

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