2021
DOI: 10.7717/peerj.11279
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Methyl jasmonate enhances ursolic, oleanolic and rosmarinic acid production and sucrose induced biomass accumulation, in hairy roots of Lepechinia caulescens

Abstract: Background Ursolic (UA), oleanolic (OA) and rosmarinic (RA) acids are bioactive metabolites found in Lepechinia caulescens that have generated interest for their health benefits, which include antimicrobial, antioxidant, antimutagenic, gastroprotective, antidiabetic, antihypertensive and anti-inflammatory properties, among others. To date, very few attempts have been made to evaluate the potential for simultaneous production of these bioactive compounds, using a biotechnological approach. Hairy … Show more

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Cited by 12 publications
(4 citation statements)
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“…Lepechinia caulescens (Ortega) Epling (Lamiaceae) roots transformed with R. rhizogenes ATCC 15834 in optimum conditions (MS salts, B5 vitamins, 4.5% sucrose) produced 41.7 mg/g DW of RA. The content increased to c. 60 mg/g DW after the elicitation with 200 μM of MeJa (24 h) [ 181 ]. Numerous HRs of the Lamiaceae plants were established for the active metabolite production, including the formerly described HRs of Mentha spicata (70 μg/g DW of RA and 60 μg/g DW of lithospermic acid B) [ 57 ] and Leonotis nepetifolia (2.6 mg/g DW of RA) [ 58 ].…”
Section: Phenolic and Polyphenolic Antioxidants In Hrsmentioning
confidence: 99%
“…Lepechinia caulescens (Ortega) Epling (Lamiaceae) roots transformed with R. rhizogenes ATCC 15834 in optimum conditions (MS salts, B5 vitamins, 4.5% sucrose) produced 41.7 mg/g DW of RA. The content increased to c. 60 mg/g DW after the elicitation with 200 μM of MeJa (24 h) [ 181 ]. Numerous HRs of the Lamiaceae plants were established for the active metabolite production, including the formerly described HRs of Mentha spicata (70 μg/g DW of RA and 60 μg/g DW of lithospermic acid B) [ 57 ] and Leonotis nepetifolia (2.6 mg/g DW of RA) [ 58 ].…”
Section: Phenolic and Polyphenolic Antioxidants In Hrsmentioning
confidence: 99%
“…In the case of the genus Isodon, compounds with a Kaurano-type skeleton predominated, and some common cases among the species were adenanthine (C16), eriocalyxin B (C17), and oridonine (C18) [114,117,169]. Finally, the presence of triterpenes, such as oleanolic acid (19), ursolic acid (20), stigmasterol (21), and their derivatives, was very common in the subfamily Nepetoideae (Figure 7) [210][211][212]. Chemical structures of the representative bioactive metabolites are included in Figure 7.…”
Section: Phytochemistrymentioning
confidence: 99%
“…As most PNPs belong to secondary metabolites, the biosynthesis of PNPs depending on cell types and growth stages in plants is usually regulated by environmental factors. Accordingly, there is a positive correlation between the up-regulated expression level of genes and the accumulation of PNPs. , Typically, methyl jasmonate (MeJA) is a chemical that was widely used in the activation of the biosynthesis of secondary metabolites in specific tissues of plants, leading to an enhanced yield of PNPs and their derivatives. , Hence, the combination of transcriptome data and metabolic profiling has emerged as a powerful tool for the functional discovery of genes related to the biosynthesis of PNPs (Figure ).…”
Section: Identification Of Candidate Genes For Biosynthetic Pathway O...mentioning
confidence: 99%
“…42,43 Typically, methyl jasmonate (MeJA) is a chemical that was widely used in the activation of the biosynthesis of secondary metabolites in specific tissues of plants, leading to an enhanced yield of PNPs and their derivatives. 44,45 Hence, the combination of transcriptome data and metabolic profiling has emerged as a powerful tool for the functional discovery of genes related to the biosynthesis of PNPs (Figure 2). Differential expression gene (DEG) analysis based on the RNA-seq data is a common strategy for the gene function prediction, which makes full use of the different gene expression between the reference and test groups or different organs or tissues of plants.…”
mentioning
confidence: 99%