Methyl Pothoscandensate, a New ent‐18(4→3)‐Abeokaurane from Pothos scandens

Abstract

Methyl pothoscandensate (1), a new molecular skeleton of ent‐18(4→3)‐abeokaurane, along with eight known compounds was isolated from the whole plant of Pothos scandens. The structure of the new compound was established by spectroscopic techniques and confirmed by single‐crystal X‐ray diffraction. The inhibitory activity of selected compounds against porcine respiratory and reproductive syndrome virus (PRRSV) was measured by the cytopathic effect (CPE) method. Compound 1 showed weak effect on PRRSV with an IC50 value of 40.3±8.3 μM (TI=15.7).

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“…(-)-serotobenine (2), indole-3-aldehyde (3) and Neoechinulin A (4) are indole alkaloid from the plants P. scandens and P. chinensis. [12][13] Fig.…”

“…The preliminary phytochemical screening reported several secondary metabolites from the different parts of this plant. [10][11][12][13][14][15] Numerous compounds have been reported from this genus. The extracts, essential oils and the compounds isolated from various species of Pothos exhibited several biological activities, including antimicrobial, antioxidant, antipyretic, anti-diabetes, bronchodilator, burn wound healing, anticariogenic, thrombolytic, anticancer, peritoneal mast cell stabilization, hyaluronidase inhibitory, histamine release inhibiting activities.…”

Pharmacological and Phytochemical Updates on Pothos scandens L

“…28 The leaves are used as tea by the Dai ethnic minority. 37 The powdered leaves are applied to the body to cure small pox, increases milk in cows, stem and leaves are used in snake bites. 48 For a summary of the ethnomedicinal uses reported for P. scandens ( Table 1).…”

“…reported the isolation of eighteen compounds from the methanol extract of stem and root, namely pothobanoside A (1), pothobanoside B (2), pothobanoside C (3), pothobanol (4), eleutherazine B (5), isoschaftoside (6), vicenin-2 (7), neoschaftoside (8), vitexin 2՜ ՜-O-xyloside (9), kaempferol 3-O-gentiobioside (10), quercetin 3 O-gentioside (11), isorhamnetin3-Ogentiobioside (12), canthoside B (13), zizybeoside I (14), markhamioside F (15), canthoside A (16), 1, 2, 3, 4-tetrahydro-3-carboxy-2-carboline (17), scoparin 2՜ ՜ -Oxyloside(18). 10,53-64 According to Liu et al from the AcOEt extract of the whole plant of P. scandens yields a novel diterpenoid methyl pothoscandensate(19) as well as known compounds N-trans-cinnamoyltyramine (20), N-trans-feruloyltyramine (21), N-trans-p-cumaroyltyramine (22), (-)-serotobenine (23), (3β)-ent-kaurane-3,16,17-triol (24), (+)-syringaresinol (25) 37,[38][39][40][41][42][43][44][45][46][47]. According to Gupta et al 5-Oxoundecyl-3-hydroxypentanoate (26) was isolated from theethanolic extract of aerial part of P. scandens including known compounds 28.…”

In vitro anti-inflammatory activity of Pothos scandens extract in RAW 264.7 cells

“…P. scandens is widely distributed in Asian countries and Madagascar [7]. P. scandens is an edible plant, and Dai people drink boiled water decoctions of its leaves as tea [8]. The leaves of the plant are used to reduce swelling in traumatic areas in Sri Lanka [9], and the compressed fruits and leaves are used as blood coagulants in China [7].…”