Methyl-prednisolone in neurologic complications ofMycoplasma pneumonia

Gücüyener, Kıvılcım; Şimşek, Filiz; Yılmaz, Özlem; Serdaroğlu, Ayşe

doi:10.1007/bf02859473

Cited by 20 publications

(18 citation statements)

References 14 publications

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“…Unfortunately, the available literature data are not helpful in providing guidance regarding the efficacy of antibiotic therapies due to the small sample size [5]. The possible immunological origin of M. pneumoniae encephalitis has led to the suggestion that treatment with corticosteroids may be beneficial [5,8]. Our patient received a high-dose steroid treatment combined with azithromycin and the prognosis was good in both respiratory and nervous systems.…”

Section: Discussionmentioning

confidence: 87%

Meningitis associated with bilateral optic papillitis following Mycoplasma pneumoniae infection

et al. 2011

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Mycoplasma pneumoniae (M. pneumoniae) is a frequent cause for human infection, and central nervous system disease associated with M. pneumoniae infection is being reported with increasing frequency. We described herein a 60-year-old woman who developed meningitis associated with bilateral optic papillitis following M. pneumoniae infection and discussed the possible mechanisms. To our knowledge, there have been only a few reports that described the meningitis complicated by bilateral optic papillitis in association with M. pneumoniae infection. Our case highlighted the protean neurological manifestations of M. pneumoniae infection.

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Section: Discussionmentioning

confidence: 87%

Meningitis associated with bilateral optic papillitis following Mycoplasma pneumoniae infection

et al. 2011

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“…Limited information from case reports suggests that highdose steroid therapy may be effective in reversing neurological symptoms in children with complicated M. pneumoniae infection (175), and some clinicians recommend use of steroids in combination with an antibiotic that can penetrate the CNS, such as doxycycline or chloramphenicol (105,208). Azithromycin and clarithromycin are commonly used for M. pneumoniae respiratory infections, and both have been used successfully in M. pneumoniae CNS infections, even though macrolides penetrate poorly into the CNS (175,384).…”

Section: Treatment Of Infections Due To M Pneumoniaementioning

confidence: 99%

“…Azithromycin and clarithromycin are commonly used for M. pneumoniae respiratory infections, and both have been used successfully in M. pneumoniae CNS infections, even though macrolides penetrate poorly into the CNS (175,384). A recent review of steroid therapy in M. pneumoniae CNS cases suggests that it is often beneficial, particularly in severe cases.…”

Section: Treatment Of Infections Due To M Pneumoniaementioning

confidence: 99%

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2004

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Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. Serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. The severity of disease appears to be related to the degree to which the host immune response reacts to the infection. Extrapulmonary complications involving all of the major organ systems can occur in association with M. pneumoniae infection as a result of direct invasion and/or autoimmune response. The extrapulmonary manifestations are sometimes of greater severity and clinical importance than the primary respiratory infection. Evidence for this organism's contributory role in chronic lung conditions such as asthma is accumulating. Effective management of M. pneumoniae infections can usually be achieved with macrolides, tetracyclines, or fluoroquinolones. As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur

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“…Although the positive PCR in CSF are very useful in cases, are insufficient .We prefer to test CSF from both serological and PCR aspect in highly suspicious cases (18). Anti-microbial or immune modulating therapies (Corticosteroids, intravenous immunoglobulin) had possible benefits in treating such complications (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…M. pneumonia (DNA-PCR) was the most common agent implicated in unexplained encephalitis in the California Encephalitis Project (14). Many studies recommend various anti-microbial or immune modulating therapies in treating CNS manifestations of M. pneumonia (15)(16)(17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Mycoplasma pneumonia in Cerebrospinal Fluids of Febrile Children With Neurologic Manifestations: A Cross Sectional Study: Tehran, Iran

Noorbakhsh

Zarabi

Shamshiri

et al. 2013

Jundishapur J Microbiol

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Background:The clinical spectrum of Mycoplasma pneumoniae CNS diseases had a wide range. Encephalitis and meningoencephalitis are the most frequent neurological manifestations, but cases of optic neuritis, transverse myelitis, Guillain-Barré syndrome (GBS), etc. have been reported Objectives: To determine the role of M. pneumonia (using PCR and serologically test) in Cerebro Spinal Fluid (CSF) in febrile children with neurologic manifestations (in comparison with normal CSF). Materials and Methods:This cross sectional study was done in pediatric wards of Rasoul hospital in Tehran between 2008 -2010 upon 55 febrile cases with neurological signs and 10 controls with normal CSF (simple febrile seizure). The CSF samples tested for M. pneumonia DNA (PCR); and Immune Globulin G (IgG) level. Chi square values < 0.05 were considered statistically significant. Results: Positive PCR found in 1 case with Guillan Barre syndrome (1/53; 2%) and none of controls; IgG-CSF level (Cut off 0.0025) had significant difference between cases and controls (Kappa = 0.27, P Value = 0.000). The lowest and highest IgG level observed in aseptic meningitis, and convulsive cases respectively. 73% sensitivity; 90% specificity; 100% Variance (PPV); 28.8% Net Present Value (NPV) determined for IgG-CSF test. Conclusions: Even, very low amount of CSF-IgG with good specificity (90%); could differentiate cases and controls (P = 0.000). The CSF-IgG test (sensitivity 70%, NPV 28.8%) was weak for ruling out the M. pneumonia in cases. positive PCR was rare (2%) in CSF of cases and controls but is more reliable for diagnosing the recent M. pneumonia infection. We prefer to assay the CSF for both serology and PCR in highly suspicious cases. Anti-microbial or immune modulating therapies had possible benefits.

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Methyl-prednisolone in neurologic complications ofMycoplasma pneumonia

Cited by 20 publications

References 14 publications

Meningitis associated with bilateral optic papillitis following Mycoplasma pneumoniae infection

Meningitis associated with bilateral optic papillitis following Mycoplasma pneumoniae infection

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

Mycoplasma pneumonia in Cerebrospinal Fluids of Febrile Children With Neurologic Manifestations: A Cross Sectional Study: Tehran, Iran

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