Methylation mediated by an anthocyanin,<i>O</i>-methyltransferase, is involved in purple flower coloration in<i>Paeonia</i>

Du, Hui; Wu, Jie; Ji, Kui-Xian; Zeng, Qing‐Yin; Bhuiya, Mohammad-Wadud; Su, Shang; Shu, Qingyan; Ren, Hongxu; Liu, Zheng-An; Wang, Liang-Sheng

doi:10.1093/jxb/erv365

Cited by 90 publications

(79 citation statements)

References 61 publications

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“…However, the relatively low stability and bioavailability of anthocyanins are the primary barrier to limit the wide and effective applications [9][10][11], raising up the importance of reducing the degradation of anthocyanins and controlling release. So far, encapsulation [12][13][14][15], composite [16][17][18][19] and group substitution [20][21][22][23][24] are the three main means used for anthocyanin stabilization. Some studies have been carried out on the adsorption of pigments by Fe 3 O 4 [25] and the stabilization of Fe 3+ [26,27].…”

Section: Introductionmentioning

confidence: 99%

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

et al. 2019

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Anthocyanins are a class of antioxidants extracted from plants, with a variety of biochemical and pharmacological properties. However, the wide and effective applications of anthocyanins have been limited by their relatively low stability and bioavailability. In order to expand the application of anthocyanins, Fe 3 O 4 /anthocyanin magnetic biocomposite was fabricated for the storage and release of anthocyanin in this work. The magnetic biocomposite of Fe 3 O 4 magnetic nanoparticle-loaded anthocyanin was prepared through physical intermolecular adsorption or covalent cross-linking. Scanning electron microscopy (SEM), Dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and thermal analysis were used to characterize the biocomposite. In addition, the anthocyanin releasing experiments were performed. The optimized condition for the Fe 3 O 4 /anthocyanin magnetic biocomposite preparation was determined to be at 60 • C for 20 h in weak alkaline solution. The smooth surface of biocomposite from SEM suggested that anthocyanin was coated on the surface of the Fe 3 O 4 particles successfully. The average size of the Fe 3 O 4 /anthocyanin magnetic biocomposite was about 222 nm. Under acidic conditions, the magnetic biocomposite solids could be repeatable released anthocyanin, with the same chemical structure as the anthocyanin before compounding. Therefore, anthocyanin can be effectively adsorbed and released by this magnetic biocomposite. Overall, this work shows that Fe 3 O 4 /anthocyanin magnetic biocomposite has great potential for future applications as a drug storage and delivery nanoplatform that is adaptable to medical, food and sensing.

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Section: Introductionmentioning

confidence: 99%

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

et al. 2019

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“…O-methyltransferases have been implicated in lignin biosynthesis (Zhong et al, 1998) and in modifying flavonoids as well as esters with aromatic vicinal dihydroxyl groups (Ibdah et al, 2003). Methylation of certain anthocyanins alters the intensity of pigment hues, generating their diversity in stability and functions, likely related to their function as protectants against UV, pigmentation, antioxidation or attractants of insects (Du et al, 2015). In Arabidopsis and the cyanobacterium Synechococcus, trimethylation of glycine yields glycinebetaine, which confers tolerance to experimental stresses that include low temperature, drought and high salinity (Waditee et al, 2005).…”

Section: Metabolite Methylation: Functions and Influence On Chromatinmentioning

confidence: 99%

Who Rules the Cell? An Epi-Tale of Histone, DNA, RNA, and the Metabolic Deep State

Leung

Gaudin

2020

Front. Plant Sci.

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Epigenetics refers to the mode of inheritance independent of mutational changes in the DNA. Early evidence has revealed methylation, acetylation, and phosphorylation of histones, as well as methylation of DNA as part of the underlying mechanisms. The recent awareness that many human diseases have in fact an epigenetic basis, due to unbalanced diets, has led to a resurgence of interest in how epigenetics might be connected with, or even controlled by, metabolism. The Next-Generation genomic technologies have now unleashed torrents of results exposing a wondrous array of metabolites that are covalently attached to selective sites on histones, DNA and RNA. Metabolites are often cofactors or targets of chromatin-modifying enzymes. Many metabolites themselves can be acetylated or methylated. This indicates that the acetylome and methylome can actually be deep and pervasive networks to ensure the nuclear activities are coordinated with the metabolic status of the cell. The discovery of novel histone marks also raises the question on the types of pathways by which their corresponding metabolites are replenished, how they are corralled to the specific histone residues and how they are recognized. Further, atypical cytosines and uracil have also been found in eukaryotic genomes. Although these new and extensive connections between metabolism and epigenetics have been established mostly in animal models, parallels must exist in plants, inasmuch as many of the basic components of chromatin and its modifying enzymes are conserved. Plants are chemical factories constantly responding to stress. Plants, therefore, should lend themselves readily for identifying new endogenous metabolites that are also modulators of nuclear activities in adapting to stress.

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“…These candidates along with known caffeoyl-co A O-methyltransferases (CCoAOMTs), anthocyanin O-methyltransferase (AOMTs) and caffeic acid O-methyltransferases (CaOMTs) gathered from NCBI. Candidate sequence selection was based in part on phylograms from Provenzano et al 23 and Du et al 24 . Sequences were aligned in R using the DECIPHER 25 package, and a phylogram was created using the phangorn package 26 .…”

Section: Methyltransferase Candidatesmentioning

confidence: 99%

Linking Anthocyanin Diversity, Hue, And Genetics In Purple Corn

Juvik

Chatham

2020

Preprint

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While maize with anthocyanin-rich pericarp (purple corn) is rising in popularity as a source of natural colorant for foods and beverages, information on color range and stabilityfactors associated with anthocyanin decorations and compositional profiles-are currently limited. Using the natural anthocyanin diversity present in a purple corn landrace, Apache Red, we generated a population with variable flavonoid profiles-flavonol-anthocyanin condensed forms (0-83%), acylated anthocyanins (2-72%), pelargonidin-derived anthocyanins (5-99%), and C-glycosyl flavone co-pigments up to 1904 µg/g-all of which contributed in part to the absorbance profile, used here as a proxy for hue. This variability offers targets of selection for breeders looking to expand both stability and the available range of colors that can be sourced from purple corn. With genotyping-by-sequencing of this population we mapped these anthocyanin profile traits. Major QTL for anthocyanin type were found near loci previously identified only in aleurone-pigmented maize varieties [Purple aleurone1 (Pr1) and Anthocyanin acyltransferase1 (Aat1)]. A QTL near P1 (Pericarp color1) was found for both flavone content and flavanol-anthocyanin condensed forms. A significant QTL associated with peonidin-derived anthocyanins near a candidate S-adenosylmethionine-dependent methyltransferase was also identified, warranting further investigation. This population represents the most anthocyanin diverse pericarp-pigmented maize variety characterized to date. Moreover, the candidates identified here will serve as branching points for future research studying the genetic and molecular processes determining anthocyanin profile in pericarp.

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Methylation mediated by an anthocyanin,O-methyltransferase, is involved in purple flower coloration inPaeonia

Abstract: HighlightA single amino acid residue substitution at position 87 from arginine to leucine of AOMT is vital for anthocyanin methylation in Paeonia plants, especially for purple flower coloration.

Cited by 90 publications

References 61 publications

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

Preparation and pH Controlled Release of Fe3O4/Anthocyanin Magnetic Biocomposites

Who Rules the Cell? An Epi-Tale of Histone, DNA, RNA, and the Metabolic Deep State

Linking Anthocyanin Diversity, Hue, And Genetics In Purple Corn

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