Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma

Gao, Feng; Liu, Guozhong; Wang, Jingwen; Huang, Shirong; Ding, Fadian; Lian, Wei; Lv, Xiaoting; Guo, Yujia; Fan, Xiangqun; Zhang, Sheng; Liu, Qicai

doi:10.1155/2021/2088345

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…The high frequency of promoter methylation of CALCA gene has been found in cervical cancer and bladder cancer [ 159 , 160 ]. Similarly, the previous study of our research group also found that the CpG island methylation of CALCA and CALCB in pancreatic ductal adenocarcinoma was significantly higher than that in adjacent tissues and CGRP participated in cell proliferation, apoptosis, differentiation, and survival through the AKT/CREB signaling pathway and finally promoted the occurrence and development of tumors [ 33 ]. CpG island hypermethylation of CALCA occurs in juvenile mononuclear leukemia (JMML), regaining the hypermethylated phenotype upon relapse after treatment [ 161 ].…”

Section: Cgrp and Tumor Stem Cellssupporting

confidence: 74%

“…High expression of CGRP could not only promote the migration of mesenchymal stem cells (MSCs) to damaged tissues [ 29 ] but also promote stem cell differentiation [ 30 , 31 ]. CGRP is also considered as a tumor growth factor to induce the occurrence and development of malignant tumors [ 32 , 33 ]. Therefore, the abnormal expression of CGRP gene can regulate the ability of differentiation and self-renewal in stem cells.…”

Section: Introductionmentioning

confidence: 99%

“…It is rich in CpG, has high content of G+C, and contains several rare restriction endonuclease digestion sites and two different CpG-rich regions, one around exon 1 and another in about 1.5 kb upstream in a nonmethylated state generally [ 38 ]. DNA methylation regulates cell proliferation, apoptosis, and gene expression, which is closely related to tumor [ 33 , 39 ]. Abnormal methylation levels of CALCA promoter and exon can change cell stemness [ 35 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

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CGRP: A New Endogenous Cell Stemness Maintenance Molecule

Chen

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Stem cells have the ability of self-replication and multidirectional differentiation, but the mechanism of how stem cells “maintain” this ability and how to “decide” to give up this state and differentiate into cells with specific functions is still unknown. The Nobel Prize in physiology and medicine in 2021 was awarded to “temperature and tactile receptor,” which made the pain receptor TRPV1-calcitonin gene-related peptide (CGRP) pathway active again. The activation and blocking technology of CGRP has been applied to many clinical diseases. CGRP gene has complex structure and transcription process, with multiple methylation and other modification sites. It has been considered as a research hotspot and difficulty since its discovery. Drug manipulation of TRPV1 and inhibition of CGRP might improve metabolism and prolong longevity. However, whether the TRPV1-neuropeptide-CGRP pathway is directly or indirectly involved in stem cell self-replication and multidirectional differentiation is unclear. Recent studies have found that CGRP is closely related to the migration and differentiation of tumor stem cells, which may be realized by turning off or turning on the CGRP gene expression in stem cells and activating a variety of ways to regulate stem cell niches. In this study, we reviewed the advances in researches concentrated on the biological effects of CGRP as a new endogenous switching of cell stemness.

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Section: Cgrp and Tumor Stem Cellssupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CGRP: A New Endogenous Cell Stemness Maintenance Molecule

Chen

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…This aids cancer cells in clearing ROS (reactive oxygen species), maintaining energy equilibrium, and enhancing resistance to nutritional deficiency ( 37 ). In the conventional tissue environment of pancreatic cancer, CGRP exhibits a high degree of methylation, affecting the AKT-CREB signaling pathway, further fostering pancreatic cancer initiation and progression ( 38 ).…”

Section: Empowering Tumor Cells To Thrivementioning

confidence: 99%

Periampullary cancer and neurological interactions: current understanding and future research directions

Wang,

Liu,

Tian

et al. 2024

Front. Oncol.

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Periampullary cancer is a malignant tumor occurring around the ampullary region of the liver and pancreas, encompassing a variety of tissue types and sharing numerous biological characteristics, including interactions with the nervous system. The nervous system plays a crucial role in regulating organ development, maintaining physiological equilibrium, and ensuring life process plasticity, a role that is equally pivotal in oncology. Investigations into nerve-tumor interactions have unveiled their key part in controlling cancer progression, inhibiting anti-tumor immune responses, facilitating invasion and metastasis, and triggering neuropathic pain. Despite many mechanisms by which nerve fibers contribute to cancer advancement still being incompletely understood, the growing emphasis on the significance of nerves within the tumor microenvironment in recent years has set the stage for the development of groundbreaking therapies. This includes combining current neuroactive medications with established therapeutic protocols. This review centers on the mechanisms of Periampullary cancer’s interactions with nerves, the influence of various types of nerve innervation on cancer evolution, and outlines the horizons for ongoing and forthcoming research.

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“…CALCA (αCGRP) and CALCB (βCGRP) methylation increased in pancreatic adenocarcinoma cells, and, under that condition, p-CREB and p-AKT levels decreased [ 262 ].…”

Section: Involvement Of the Tachykinin And Calcitonin/calcitonin Gene...mentioning

confidence: 99%

Peptidergic Systems and Cancer: Focus on Tachykinin and Calcitonin/Calcitonin Gene-Related Peptide Families

Sánchez

Rodríguez

Coveñas

2023

Cancers

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The roles played by the peptides belonging to the tachykinin (neurokinin A and B) and calcitonin/calcitonin gene-related peptide (adrenomedullin, adrenomedullin 2, amylin, and calcitonin gene-related peptide (CGRP)) peptide families in cancer development are reviewed. The structure and dynamics of the neurokinin (NK)-2, NK-3, and CGRP receptors are studied together with the intracellular signaling pathways in which they are involved. These peptides play an important role in many cancers, such as breast cancer, colorectal cancer, glioma, lung cancer, neuroblastoma, oral squamous cell carcinoma, phaeochromocytoma, leukemia, bladder cancer, endometrial cancer, Ewing sarcoma, gastric cancer, liver cancer, melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal carcinoma, and thyroid cancer. These peptides are involved in tumor cell proliferation, migration, metastasis, angiogenesis, and lymphangiogenesis. Several antitumor therapeutic strategies, including peptide receptor antagonists, are discussed. The main research lines to be developed in the future are mentioned.

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Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma

Cited by 4 publications

References 21 publications

CGRP: A New Endogenous Cell Stemness Maintenance Molecule

CGRP: A New Endogenous Cell Stemness Maintenance Molecule

Periampullary cancer and neurological interactions: current understanding and future research directions

Peptidergic Systems and Cancer: Focus on Tachykinin and Calcitonin/Calcitonin Gene-Related Peptide Families

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