Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents

Scholl, Jamie L.; King, Zach R.; Pearson, Kami; Kallsen, Noah A.; Ehli, Erik A.; Fercho, Kelene A.; Brown-Rice, Kathleen; Forster, Gina L.; Baugh, Lee A.

doi:10.1016/j.bbih.2022.100505

Cited by 4 publications

(1 citation statement)

References 90 publications

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“…This method is based on a set of 71 CpG sites that are largely non-overlapping. The Hannum clock was chosen as it has been previously demonstrated to have high sensitivity to both environmental and cellular aging processes, including inflammatory biomarkers (Irvin et al, 2018) similar to those that would be expected in ACoA populations (Scholl et al, 2022), as well as being sensitive to psychiatric conditions such as post-traumatic stress disorder (Morrison et al, 2019), and socioeconomic position (Hughes et al, 2018). Chronological age was subtracted from predicted brain age to create the predicted epigenetic age difference score (PEAD).…”

Section: Methodsmentioning

confidence: 99%

Differing effects of alcohol use on epigenetic and brain age in adult children of alcoholic parents

Scholl,

Pearson,

Fercho

et al. 2023

Preprint

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It is known that being the adult child of an alcoholic (ACoA) can confer a wide variety of increased health and psychological risks, including higher rates of anxiety, depression, and posttraumatic stress disorder symptoms. Additionally, ACoAs are at greater risk of developing substance use disorders than individuals from non-alcoholic families. To better understand the psychobiological factors underlying these risks, ACoA individuals with risky hazardous alcohol use (n=14) and those not engaged in hazardous use (n=14) were compared to a group of healthy controls. We examined structural brain differences and applied machine learning algorithms to predict biological brain and DNA methylation ages to investigate differences between these groups. Contrary to our hypothesis, we found that hazardous and non-hazardous ACoA groups had lower predicted brain ages than the healthy control group (n=100), which may result from neuro-developmental differences between ACoA groups and controls. When examining specific brain regions, we observed decreased cortical volume within bilateral pars orbitalis and frontal poles, as well as the left middle temporal gyrus and entorhinal cortex within the hazardous alcohol ACoA group, all areas consistent with previous research examining how alcohol use affects brain structure. When looking at the epigenetic aging data, the hazardous ACoA participants had increased predicted epigenetic age difference scores compared to the control group (n=34) and the non-hazardous ACoA participant groups. In summary, the results demonstrate a decreased brain age in the ACoAs compared to control, concurrent with increased epigenetic age specifically in the hazardous ACoA group, laying the foundation for future research to identify individuals that may have an increased susceptibility to developing hazardous alcohol use. Together, these results provide a better understanding of the associations between epigenetic factors, brain structure, and alcohol use disorders.

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Section: Methodsmentioning

confidence: 99%

Differing effects of alcohol use on epigenetic and brain age in adult children of alcoholic parents

Scholl,

Pearson,

Fercho

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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A review on the reciprocal interactions between neuroinflammatory processes and substance use and misuse, with a focus on alcohol misuse

Gano

Deak

Pautassi

2023

The American Journal of Drug and Alcohol Abuse

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Interplay of the indicators of physical development and psychological status in the young adult medical students

Chevzhik,

Milushkina,

Shemyakov

et al. 2024

Российский Вестник Гигиены

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Currently, there is increasing number of overweight people all over the world. The increase in the incidence of depression among the population, especially among adolescents and young adults, has been reported. The study was aimed to determine the relationship between excess body weight and severity of depression in the young adult students taught at the initial courses in the medical university. The study involved 230 junior medical students (163 females and 67 males) having no chronic disorders. Body mass index (BMI) was determined in the subjects. The depression severity was defined using the Beck Depression Inventory. The analysis showed that the average BMI was 3.0 ± 3.9 AU in males and 22.0 ± 4.3 AU in females. The share of underweight male subjects was 7.5%, while the share of underweight females was 10.5%; 28.3% of males and 13.5% of female subjects had excess body weight and obesity of varying severity. No signs of depression were found in 66.0% of males and 61.0% of females. We revealed no significant correlation between BMI and depression.

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Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents

Cited by 4 publications

References 90 publications

Differing effects of alcohol use on epigenetic and brain age in adult children of alcoholic parents

Differing effects of alcohol use on epigenetic and brain age in adult children of alcoholic parents

A review on the reciprocal interactions between neuroinflammatory processes and substance use and misuse, with a focus on alcohol misuse

Interplay of the indicators of physical development and psychological status in the young adult medical students

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