Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

Raneros, Aroa Baragaño; Martín-Palanco, Vanesa; Fernández, Agustín F.; Rodríguez, Ramón María Alvargonzález; Fraga, Mario F.; López‐Larrea, Carlos; Suárez-Álvarez, Beatriz

doi:10.1038/gene.2014.58

Cited by 81 publications

(55 citation statements)

References 58 publications

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“…NK group 2, member D (NKG2D) receptors are located on the surface of NK cells and in some T cells to recognize ligands on the cellular surface 80. Tumors can exploit this by using sustained enhanced ligand production to downregulate the expression levels of NKG2D receptors and can directly blunt NKG2D via production of TGF-β as well 81,82.…”

Section: Tumor Microenvironmentmentioning

confidence: 99%

Mechanism of immune evasion in breast cancer

Wang¹,

Zhang²,

Song³

et al. 2017

OTT

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Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body’s immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail.

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Section: Tumor Microenvironmentmentioning

confidence: 99%

Mechanism of immune evasion in breast cancer

Wang¹,

Zhang²,

Song³

et al. 2017

OTT

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“…Current limitations of T cell and NK cell immunotherapy. 123,124 Rendering NK cells resistant to tumor microenvironment using gene modification rection of specificity enabled these cells to eliminate previously NK cell-resistant tumors in murine models. 100 Similarly, another group targeted multiple myeloma cells by transfecting NK cells with an anti-CD138 CAR.…”

Section: Genetically Modified Natural Killer Cellsmentioning

confidence: 99%

T-cell and natural killer cell therapies for hematologic malignancies after hematopoietic stem cell transplantation: enhancing the graft-versus-leukemia effect

Cruz

Bollard

2015

Haematologica

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Hematopoietic stem cell transplantation has revolutionized the treatment of hematologic malignancies, but infection, graft-versus-host disease and relapse are still important problems. Calcineurin inhibitors, T-cell depletion strategies, and immunomodulators have helped to prevent graft-versus-host disease, but have a negative impact on the graft-versus-leukemia effect. T cells and natural killer cells are both thought to be important in the graft-versus-leukemia effect, and both cell types are amenable to ex vivo manipulation and clinical manufacture, making them versatile immunotherapeutics. We provide an overview of these immunotherapeutic strategies following hematopoietic stem cell transplantation, with discussions centered on natural killer and T-cell biology. We discuss the contributions of each cell type to graft-versus-leukemia effects, as well as the current research directions in the field as related to adoptive cell therapy after hematopoietic stem cell transplantation. ABSTRACT

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“…It should be acknowledged that when tumors develop mechanisms of immune evasion, some of these mechanisms include also downregulation of NK cell ligands such as NKG2D and DNAM1 receptors, which can therefore lead to inhibition of NK cell functions [77][78][79][80].…”

Section: Natural Killer Cellsmentioning

confidence: 99%

The Multifaceted Nature of Tumor Microenvironment in Breast Carcinomas

et al. 2020

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Heterogeneity in breast carcinomas can be appreciated at various levels, from morphology to molecular alterations, and there are well-known genotypic-phenotypic correlations. Clinical decision-making is strictly focused on the evaluation of tumor cells and is based on the assessment of hormone receptors and of the HER2 status, by means of a combination of immunohistochemical and in situ hybridization techniques. The tumor microenvironment (TME) also shows a multifaceted nature stemming from the different actors populating the intratumoral and the peritumoral stroma of breast carcinomas. Of note, we have now evidence that tumor-infiltrating lymphocytes (TILs) are clinically meaningful as their quantification in the intratumoral stroma strongly correlates with good prognosis, in particular in triple-negative and HER2-positive breast cancer patients. Nevertheless, TILs are just one of the many actors orchestrating the com-plexity of the TME, which is populated by immune and nonimmune cells (cancer-associated fibroblasts, cancer-associated adipocytes), as well as non-cellular components such as chemical inflammation mediators. In this review article we will overview the main features of the distinct cell compartments by discussing (i) the potential impact the TME may have on the prognostic stratification of breast cancers and (ii) the possible predictive value of some markers in the context of immunotherapy in light of the recent results of phase III studies in advanced and early triple-negative breast cancer patients.

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Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

Cited by 81 publications

References 58 publications

Mechanism of immune evasion in breast cancer

Mechanism of immune evasion in breast cancer

T-cell and natural killer cell therapies for hematologic malignancies after hematopoietic stem cell transplantation: enhancing the graft-versus-leukemia effect

The Multifaceted Nature of Tumor Microenvironment in Breast Carcinomas

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