2020
DOI: 10.1016/j.omto.2020.10.004
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Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma

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Cited by 8 publications
(14 citation statements)
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“…The adhesion of MM cells to bone marrow stem cells not only promotes proliferation but also enhances drug resistance by activating ERK and NF‐κB 18 . Our previous study indicated that cell adhesion is inhibited and EMT is enhanced in MM patients 16 . However, the role of E2F2 in the pathogenicity of MM in general and its involvement in MM cell adhesion in particular was explored only by a few studies 29,30 .…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…The adhesion of MM cells to bone marrow stem cells not only promotes proliferation but also enhances drug resistance by activating ERK and NF‐κB 18 . Our previous study indicated that cell adhesion is inhibited and EMT is enhanced in MM patients 16 . However, the role of E2F2 in the pathogenicity of MM in general and its involvement in MM cell adhesion in particular was explored only by a few studies 29,30 .…”
Section: Discussionmentioning
confidence: 99%
“…To detect mRNA expression in MM cells and primary MM cells, we performed RT‐qPCR as described previously 16 . Total RNA was isolated from cells using TRIzol reagent (Invitrogen).…”
Section: Methodsmentioning
confidence: 99%
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“…In line, KD of DNMT1 using siRNA was shown to decrease MM cell proliferation, due to a G1-phase block and re-expression of SOCS1 and p16, and to increase apoptosis due to cleavage of caspase 3 and PARP ( 123 , 124 ). A recent study in MM also showed that DNMT1 is responsible for the hypermethylation of tight junction protein 1 (TJP1), a negative regulator of the epithelial-to-mesenchymal transition (EMT), leading to decreased TJP1 levels and poor OS ( 125 ). The exact mechanisms behind the aberrant expression of DNMT1 are currently unknown, but studies in other cancers are indicating that the DNMT1 levels could be regulated by miR-148a ( 126 ).…”
Section: Aberrant Dna Methylation In MMmentioning
confidence: 99%