Methylation ofp15 andp16 genes in adult acute leukemia

Abstract

Providing a context for learning information and requiring learners to teach specific content has been demonstrated to enhance knowledge retention. To enhance students' appreciation of the role of science and specifically histology in clinical reasoning, disease diagnosis, and treatment, a new teaching format was created to provide clinical context, promote integration and application of science knowledge, and to foster peer teaching and learning: the Clinico‐Histologic Conference (CHC) for the Mount Sinai School of Medicine Histology course. Teams of six students were each assigned specific disease processes and were charged with creating oral presentations and handouts that taught their classmates about the clinical manifestations, etiopathogeneses, diagnoses, and treatments of the assigned processes, along with comparisons of normal histology to the pathology of the disease. Each team also created four questions, some of which were used on Histology written examinations. The physician facilitator evaluated the presentation and handouts. About two‐thirds of students agreed the CHC enhanced appreciation of the importance of histology, provided a context for integration and application of basic science to patient care and enhanced their ability to teach their peers. Student feedback demonstrated that the CHCs were successful in promoting teamwork, peer teaching, and the application of histology to diagnose diseases. The authors believe that teaching basic science content in this new format enhanced student learning and application of medical knowledge, and that this new teaching format can be adopted by other medical school courses. Anat Sci Educ. © 2011 American Association of Anatomists.

Tumor suppressor genes in normal and malignant hematopoiesis

“…Only a few studies to date have attempted to correlate p15 INK4B promoter methylation with clinical outcome. In ALL, no correlation between p15 INK4B promoter methylation with outcome (Chim et al, 2001b) or disease progression (Batova et al, 1997) was found. An inverse correlation between p15 INK4B methylation and overall survival was reported in adult AML (Wong et al, 2000).…”

DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas

“…In contrast, there is considerable data to show that inactivation of tumor suppressor genes by DNA methylation plays important roles in the pathogenesis and prognostification of hematological malignancies (Chim et al, 2001a,b, 2003b, 2004a,b, 2005a,b). For instance, methylation of retinoic acid receptor alpha (RARA), PTPN6, and DAPK genes has been implicated in pathogenesis of AML, myeloma, and CLL respectively (Reik and Walter, 2001; Chim et al, 2002, 2006; Kaneda et al, 2004).…”