Methylation on RNA: A Potential Mechanism Related to Immune Priming within But Not across Generations

Castro-Vargas, Cynthia; Linares-López, César; López-Torres, Adolfo; Wróbel, Katarzyna; Torres-Guzmán, Juan Carlos; Hernández, Gloria Angélica González; Lanz‐Mendoza, Humberto; Contreras‐Garduño, Jorge

doi:10.3389/fmicb.2017.00473

Cited by 42 publications

(33 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, our results indicate that such mechanisms should enable reactions that can be transferred not only within the organism (i.e., systemic reactions) but even across generations up to the F 2 . This might be helpful for narrowing down targets for further in-depth studies from the large range of candidate genes and mechanisms identified in T. castaneum (Ferro et al, 2017; Greenwood et al, 2017; Tate et al, 2017; Schulz et al, 2018) and other insect species (e.g., Castro-Vargas et al, 2017; Tassetto et al, 2017; Cime-Castillo et al, 2018; Mondotte et al, 2018). On a more cautionary note, our study also further supports the view that immune priming comprises a multitude of phenomena that might be based on diverse mechanisms among and even within species (for review see Contreras-Garduño et al, 2016; Milutinović and Kurtz, 2016).…”

Section: Discussionmentioning

confidence: 99%

Transgenerational Developmental Effects of Immune Priming in the Red Flour Beetle Tribolium castaneum

et al. 2019

View full text Add to dashboard Cite

Immune priming, the increased chance to survive a secondary encounter with a pathogen, has been described for many invertebrate species, which lack the classical adaptive immune system of vertebrates. Priming can be specific even for closely related bacterial strains, last up to the entire lifespan of an individual, and in some species, it can also be transferred to the offspring and is then called transgenerational immune priming (TGIP). In the red flour beetle Tribolium castaneum , a pest of stored grains, TGIP has even been shown to be transferred paternally after injection of adult beetles with heat-killed Bacillus thuringiensis . Here we studied whether TGIP in T. castaneum is also transferred to the second filial generation, whether it can also occur after oral and injection priming of larvae and whether it has effects on offspring development. We found that paternal priming with B. thuringiensis does not only protect the first but also the second offspring generation. Also, fitness costs of the immune priming became apparent, when the first filial generation produced fewer offspring. Furthermore, we used two different routes of exposure to prime larvae, either by injecting them with heat-killed bacteria or orally feeding them B. thuringiensis spore culture supernatant. Neither of the parental larval priming methods led to any direct benefits regarding offspring resistance. However, the injections slowed down development of the injected individuals, while oral priming with both a pathogenic and a non-pathogenic strain of B. thuringiensis delayed offspring development. The long-lasting transgenerational nature of immune priming and its impact on offspring development indicate that potentially underlying epigenetic modifications might be stable over several generations. Therefore, this form of phenotypic plasticity might impact pest control and should be considered when using products of bacterial origin against insects.

show abstract

Section: Discussionmentioning

confidence: 99%

Transgenerational Developmental Effects of Immune Priming in the Red Flour Beetle Tribolium castaneum

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Long noncoding RNAs (lncRNAs) have role in the establishment of long‐lasting epigenetic modifications which are causal for trained immune response (Fok et al 2019). In a recent study, T. molitor beetle model related to immune priming reported that RNA methylation as one potential mechanism within generations only but not across generations, though survival was higher in both within and across generations (Castro‐Vargas et al 2017).…”

Section: Epigenetics and Transgenerational Innate Immune Memory In Shmentioning

confidence: 99%

Trained immunity and perspectives for shrimp aquaculture

Roy

Bossier

Norouzitallab

et al. 2020

Reviews in Aquaculture

View full text Add to dashboard Cite

The global production of cultured crustaceans for 2018 is predicted to be ~8.63 million tonnes, and shrimp represents a significant portion of cultured crustaceans. Demands for shrimp are raising, also in developing countries as consumer preferences have evolved with rising incomes. Shrimp is mainly produced for consumption but during processing economically valuable products are being generated such as chitosan, which is used in cosmetics, food and beverages, agrochemicals and pharmaceuticals. However, the potential and sustainability of shrimp aquaculture production currently suffer from high mortality rates, losses due to especially bacterial and viral infections, and hence suboptimal yields. Vibrio parahaemolyticus acute hepatopancreatic necrosis and white spot syndrome virus (WSSV) disease outbreaks are examples of economically devastating disease outbreaks in shrimp. There is a need for prophylaxis of infectious diseases and for finding novel strategies for conditioning economically important shrimp broods so that they can produce more robust progenies and develop tolerance against biotic (pathogens) and abiotic stressors. Training the innate immune system of shrimp could be a possible avenue for improving animal’s health, and it might serve as potential unique strategy for conditioning the brood stock to have more robust progenies. The current review provides an overview on innate immune responses in shrimp after exposure to bacteria, viruses and abiotic stressors and on the possibilities to train the innate immune system of shrimp in order to improve health, not only of the animal itself but also of its progeny.

show abstract

“…These signals include the transfer of microbial degradation products (i.e. PAMPs) to their developing embryos to prime their immune response (Freitak et al, 2014), or via epigenetic mechanisms, such as DNA chromatin modification or small RNA, to elevate the constitutive expression of immune effector genes (Castro-Vargas et al, 2017;Norouzitallab et al, 2016). Paternal immune priming can also be transmitted by epigenetic mechanisms via the sperm or by compounds transferred with the seminal fluid (Eggert et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1)

Lafont

Gonçalves

Guo

et al. 2019

Developmental & Comparative Immunology

View full text Add to dashboard Cite

The oyster's immune system is capable of adapting upon exposure to a pathogen-associated molecular pattern (PAMP) to have an enhanced secondary response against the same type of pathogen. This has been demonstrated using poly(I:C) to elicit an antiviral response in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus (OsHV-1). Improved survival following exposure to poly(I:C) has been found in later life stages (within-generational immune priming) and in the next generation (transgenerational immune priming). The mechanism that the oyster uses to transfer immunity to the next generation is unknown. Here we show that oyster larvae have higher survival to OsHV-1 when their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) reconfigures antiviral gene expression in unchallenged larvae. We conclude that the improved survival of larvae might occur via maternal provisioning of antiviral compounds in the eggs. Highlights ► The molecular mechanism involved in transgenerational immune priming was investigated in the oyster, Crassostrea gigas.► Crassostrea gigas larvae have higher survival to OsHV-1 when their mothers, but not their fathers, are exposed to poly(I:C) prior to spawning. ► RNA-seq provided no evidence to suggest that parental exposure to poly(I:C) reconfigures antiviral gene expression in unchallenged larvae. ► Improved survival of C. gigas larvae might occur via maternal provisioning of antiviral compounds in the eggs.

show abstract

Methylation on RNA: A Potential Mechanism Related to Immune Priming within But Not across Generations

Cited by 42 publications

References 46 publications

Transgenerational Developmental Effects of Immune Priming in the Red Flour Beetle Tribolium castaneum

Transgenerational Developmental Effects of Immune Priming in the Red Flour Beetle Tribolium castaneum

Trained immunity and perspectives for shrimp aquaculture

Transgenerational plasticity and antiviral immunity in the Pacific oyster (Crassostrea gigas) against Ostreid herpesvirus 1 (OsHV-1)

Contact Info

Product

Resources

About