Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis

Fenton, Christopher G.; Ray, Mithlesh Kumar; Meng, Wei; Paulssen, Ruth H.

doi:10.3390/ijms241310500

Cited by 5 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research indicates that there could be a connection between MIR4435-2HG and atypical gene methylation patterns [43,101]. These findings have also been confirmed in ulcerative colitis tissues [102]. However, additional comprehensive investigation is needed to understand the precise regulatory mechanisms involved.…”

Section: Epigenetic Regulationmentioning

confidence: 82%

Biological Roles and Pathogenic Mechanisms of LncRNA MIR4435-2HG in Cancer: A Comprehensive Review

Chen,

Guan,

Zhu

et al. 2023

CIMB

View full text Add to dashboard Cite

The long non-coding RNA MIR4435-2HG has been confirmed to play a crucial regulatory role in various types of tumors. As a novel type of non-coding RNA, MIR4435-2HG plays a key role in regulating the expression of tumor-related genes, interfering with cellular signaling pathways, and affecting tumor immune evasion. Its unique structure allows it to regulate the expression of various tumor-related genes through different pathways, participating in the regulation of tumor signaling pathways, such as regulating the expression of oncogenes and tumor suppressor genes, influencing the biological behaviors of proliferation, metastasis, and apoptosis in tumors. Numerous studies have found a high expression of MIR4435-2HG in various tumor tissues, closely related to the clinical pathological characteristics of tumors, such as staging, lymph node metastasis and prognosis. Some studies have discovered that MIR4435-2HG can regulate the sensitivity of tumor cells to chemotherapy drugs, affecting tumor cell drug resistance. This provides new insights into overcoming tumor drug resistance by regulating MIR4435-2HG. Therefore, studying its molecular mechanisms, expression regulation, and its relationship with the clinical features of tumors is of great significance for revealing the mechanisms of tumor occurrence and developing new therapeutic targets.

show abstract

Section: Epigenetic Regulationmentioning

confidence: 82%

Biological Roles and Pathogenic Mechanisms of LncRNA MIR4435-2HG in Cancer: A Comprehensive Review

Chen,

Guan,

Zhu

et al. 2023

CIMB

View full text Add to dashboard Cite

show abstract

“…A recent study uncovered UC-related lncRNAs, including ZFAS1 , MIR4435-2HG , Pvt1 , and IL6-AS1 , probably regulated by upstream differentially methylated regions (DMRs). And they further identified genes implicated in the inflammatory immune responses downstream of DMR-modulated lncRNAs, including CCL18 , SERPINB1 , and SLC15A4 ( Fenton et al, 2023 ). Therefore, the interplay between the expression of lncRNAs in UC and the regulation of DNA methylation may enhance our knowledge of the immunopathogenesis in UC.…”

Section: Epigenetic Modificationsmentioning

confidence: 99%

Epigenetic regulation and therapeutic strategies in ulcerative colitis

Yan,

Gu,

Gao

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

Ulcerative colitis (UC) is an inflammatory bowel disease, and is characterized by the diffuse inflammation and ulceration in the colon and rectum mucosa, even extending to the caecum. Epigenetic modifications, including DNA methylations, histone modifications and non-coding RNAs, are implicated in the differentiation, maturation, and functional modulation of multiple immune and non-immune cell types, and are influenced and altered in various chronic inflammatory diseases, including UC. Here we review the relevant studies revealing the differential epigenetic features in UC, and summarize the current knowledge about the immunopathogenesis of UC through epigenetic regulation and inflammatory signaling networks, regarding DNA methylation, histone modification, miRNAs and lncRNAs. We also discuss the epigenetic-associated therapeutic strategies for the alleviation and treatment of UC, which will provide insights to intervene in the immunopathological process of UC in view of epigenetic regulation.

show abstract

“…The authors evaluated lncRNA expression in UC and healthy patients, which may be affected by epigenetic changes, and found several molecules associated with the regulation of genes involved in inflammatory immune response in UC. The obtained data, which unravel the interplay between lncRNA expression regulated by DNA methylation in UC, might improve the understanding of UC pathogenesis [18].…”

mentioning

confidence: 90%