Methylchloroisothiazolinone / methylisothiazolinone: epidemiological retrospective study

Lorente-Lavirgen, A.I.; Almeida, C.; Bernabeu, J.; Valero-Amaro, Victor; Lorente, Rafael

doi:10.23822/eurannaci.1764-1489.92

Cited by 2 publications

(6 citation statements)

References 7 publications

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“…First of all, many studies on MCI/ MI sensitization reported a clear female preponderance 10,12,16,26,[35][36][37] and a high percentage of patients aged over 40 years. 26,35,38 The present study, however, shows an almost equal sensitization share in male patients. Further, sensitization was more frequent among those who were <40 years old.…”

Section: Discussioncontrasting

confidence: 77%

“…Presenting the largest dataset on patch test results with MCI/MI and MI from Turkey, this study highlights some similarities and differences from previous reports on this topic. First of all, many studies on MCI/MI sensitization reported a clear female preponderance 10,12,16,26,35‐37 and a high percentage of patients aged over 40 years 26,35,38 . The present study, however, shows an almost equal sensitization share in male patients.…”

Section: Discussioncontrasting

confidence: 62%

“…56 The low sensitiza- Concomitant patch test reactions were most frequently seen with nickel and other metals, rubber allergens, and formaldehyde/formaldehyde releasers in our study. Nickel, 35 fragrances, 35,36,44,60 and preservatives such as formaldehyde 36,38,44,60,61 were reported as the main co-allergens, the latter two often coexisting in the same product together with isothiazolinones. Interestingly, fragrance allergens were positive only in a minority of patients in our study.…”

Section: Discussionmentioning

confidence: 99%

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Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone contact allergy: A 24‐year, single‐center, retrospective cohort study from Turkey

et al. 2020

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Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI allergy caused a global epidemic during the period 2010 to 2015, reaching its peak in 2013/14. Objective: To investigate the characteristics of MCI/MI and MI allergy in Turkey over 24 years. Methods: A total of 2310 patients patch tested between 1996 and 2019 with MCI/MI 0.01% aq. or MCI/MI 0.02% aq., with or without MI 0.2% aq., were analyzed. Results: The overall prevalence of contact sensitization was 3.3% (n = 77) with a peak level of 16.4% in 2015. The prevalence gradually decreased thereafter, but was still high (6.5%) in 2019. Seventy-three patients had clinically relevant sensitizations. MI could detect clinically relevant sensitizations in all seven patients with a negative patch test reaction to MCI/MI 0.02%. Non-occupational allergic contact dermatitis (ACD) was most frequently seen, mainly in women, with hand/face eczema from rinse-off or leave-on cosmetics, such as wet wipes. Occupational ACD was mainly seen among men with airborne eczema from wall paints in house painters, or with hand eczema from hair gel/wax in men's barbers. Conclusions: The prevalence of MCI/MI and MI sensitization in Turkey following the peak in 2015 is still high. This is probably due to the currently allowed level of 100 ppm for MI in rinse-off cosmetics. This needs to be urgently reduced.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone contact allergy: A 24‐year, single‐center, retrospective cohort study from Turkey

et al. 2020

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“…in several studies. [6][7][8] Through the 1980s, 1990s, and 2000s, MCI/MI has remained one of the most predominant preservative contact allergens with a stable prevalence of around 2% to 4%. 1 In the early 2000s, MI alone was introduced to industrial products and shortly thereafter, occupational cases of ACD were published.…”

Section: Resultsmentioning

confidence: 99%

“…Polysensitization may be an important factor among MCI and MI allergic patients. Interestingly, clinically relevant co‐sensitizers included fragrances and preservatives, frequent allergens in cosmetics that represent the most common source of contact allergy as reported in several studies …”

Section: Discussionmentioning

confidence: 99%

Contact allergy to isothiazolinones epidemic: Current situation

et al. 2019

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Background Since 2009, an increasing number of published cases of allergic contact dermatitis (ACD) from isothiazolinones in Europe was observed, amounting to an epidemic. However, only few studies have assessed the current situation after changes in European regulation. Objectives To analyze the incidence of isothiazolinone‐related ACD in our area in the last decade. Methods A retrospective study analyzed all patients patch tested in the allergy unit in a tertiary hospital in Spain between January 2010 and June 2019. Positive patch‐test reactions to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) and/or MI alone were recorded. Results A total of 243 patients (9.55%) with positive patch‐test reactions to MCI/MI and/or MI alone among 2544 consecutively patch‐tested patients were recorded. An initial increase in the prevalence of MCI/MI allergy was observed, from 4.5% in 2010 reaching a peak in 2015, which was followed by a significant decrease until July 2019 with 3.1% prevalence in 2019. Conclusions As shown in our data, regulatory interventions have resulted in a dramatic decrease in the prevalence of MCI and MI ACD, reaching a pre‐epidemic level of 3.1% in 2019.

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Methylchloroisothiazolinone / methylisothiazolinone: epidemiological retrospective study

Cited by 2 publications

References 7 publications

Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone contact allergy: A 24‐year, single‐center, retrospective cohort study from Turkey

Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone contact allergy: A 24‐year, single‐center, retrospective cohort study from Turkey

Contact allergy to isothiazolinones epidemic: Current situation

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