Methyldibromoglutaronitrile (Euxyl K 400): An important “new” allergen in cosmetics

Groot, Anton C. de; Ginkel, C.J.W. van; Weijland, Jan Willem

doi:10.1016/s0190-9622(96)90730-6

Cited by 71 publications

(40 citation statements)

References 27 publications

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“…In this series there were allergic reactions in 4 patients to different cosmetic preservatives. Preservative allergy from moistened wipes and toilet tissues has been identified as a particular problem in continental Europe [24,25], but this source was not frequent in our series. The vulva is a site potentially affected by ectopic nail varnish allergy, and we have 1 case where such allergy from tosylamide formaldehyde resin was felt to be relevant.…”

Section: Discussioncontrasting

confidence: 61%

The Role of Patch Testing in Perineal Disorders Affecting Women

Batchelor¹,

Young²,

Beck³

2003

Exog Dermatol

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Background: Many different materials are used in the perineal area, making it liable to contact sensitisation. Objective: We report the results of a retrospective study of patients with perineal dermatoses involving the vulva investigated for possible contact allergy. Methods: 240 female patients with dermatoses in the perineal area, specifically including the vulva, were patch tested to our standard series and a special patch test series devised for perineal problems. Results: 79 out of 240 patients (32.9%) demonstrated relevant positive results. These related to medicaments (49 patients), perfumes (22 patients), cosmetics (5 patients), dyes (4 patients) and rubber (4 patients). Conclusions: Perineal dermatoses involving the vulva may require patch testing to identify suspected and unanticipated contact allergy. An extended comprehensive series of patch test allergens will be necessary in these cases.

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Section: Discussioncontrasting

confidence: 61%

The Role of Patch Testing in Perineal Disorders Affecting Women

Batchelor¹,

Young²,

Beck³

2003

Exog Dermatol

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“…Besides other products, moist toilet paper is reported to be the major culprit for sensitizations in the anogenital area [25,26]. Moreover, preserved products used on other body sites might be transferred to the anogenital area by the hands.…”

Section: Preservativesmentioning

confidence: 99%

Contact Sensitization in the Anal and Genital Area

Bauer¹,

Oehme²,

Geier³

2011

Current Problems in Dermatology

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We analysed the patch test results in 1,374 patients suffering from dermatoses in the anogenital area (n = 561 genital dermatoses, n = 470 anal dermatoses, n = 343 anogenital dermatoses) patch tested in 44 dermatological departments of the Information Network of Departments of Dermatology from 2004 to 2008. All other patients patch tested during this time period without anogenital dermatoses formed the control group (n = 49, 142). Of the total study group, 662 (48.2%) patients were male. 179 (13%) had a past or present atopic dermatitis. The vast majority of the patients was older than 40 years (n = 989, 72%). Suspected allergen sources were first of all topical medicaments, followed by cosmetics, cleansing agents, clothes, rubber products, systemic medicaments and disinfectants. Allergic contact dermatitis was diagnosed in 409 (29.8%) of the tested patients. Patients with anogenital dermatoses were sensitized mainly to active agents of topical medicaments, in particular bufexamac (5.3%). Sensitization pattern and sensitization rates observed in patients with genital and anal involvement differed significantly. Patients with anal disease had significantly higher sensitization rates for bufexamac (9.4 vs. 1.1%), fragrance mix I (8.7 vs. 4.2%) and II (4.5 vs. 2.6%), propolis (5.4 vs. 1.9%) and methyldibromoglutaronitrile (6.3 vs. 4.1%). Patients with chronic anal dermatoses seem to have a higher risk to develop sensitizations to topically applied products and drugs than patients with genital dermatoses. Recommended patch test series (German Contact Dermatitis Research Group) are standard series, local anaesthetics series, topical antibiotics, antimycotics, steroids, ointment bases and preservative series as well as the patients' own products.

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“…Contrary to initial animal studies, MDBGN/PE has been increasingly recognized as a sensitizing agent in humans, predominantly in Europe where it was first introduced in 1985 and then later in the United States. 44 In June 2008, the European Commission Scientific Committee on Consumer Products banned the use of MDBGN in all cosmetics, including soaps and shampoos (see ec.europa.eu/health/ph_risk/ committees/04_sccp/docs/sccp_o_060.pdf, accessed 7-24-08). Most reported cases of MDBGN allergy are from exposure to cosmetics.…”

Section: Other Preservativesmentioning

confidence: 99%