2020
DOI: 10.1016/j.bmcl.2020.127221
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Methylene blue-based 7-nitro-1,2,3-benzoxadiazole NIR fluorescent probe triggered by H2S

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Cited by 25 publications
(8 citation statements)
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“…For example, phthalocyanine [27][28][29] and boron dipyrromethene dyes [30][31][32] can easily exhibit NIR emissions between 800 and 1000 nm and have been well investigated for in vivo applications. Methylene blue [33][34][35] and indocyanine green [36][37][38][39], approved by the government, have been widely used in clinical applications. However, owing to Crystals 2021, 11, 1038 2 of 11 their high chemical reactivity, most of these organic dyes can easily oxidize into molecular fragments, resulting in the loss or blue shift of luminescence.…”
Section: Introductionmentioning
confidence: 99%
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“…For example, phthalocyanine [27][28][29] and boron dipyrromethene dyes [30][31][32] can easily exhibit NIR emissions between 800 and 1000 nm and have been well investigated for in vivo applications. Methylene blue [33][34][35] and indocyanine green [36][37][38][39], approved by the government, have been widely used in clinical applications. However, owing to Crystals 2021, 11, 1038 2 of 11 their high chemical reactivity, most of these organic dyes can easily oxidize into molecular fragments, resulting in the loss or blue shift of luminescence.…”
Section: Introductionmentioning
confidence: 99%
“…Crystals 2021, 11, x FOR PEER REVIEW 2 of 11 applications. Methylene blue [33][34][35] and indocyanine green [36][37][38][39], approved by the government, have been widely used in clinical applications. However, owing to their high chemical reactivity, most of these organic dyes can easily oxidize into molecular fragments, resulting in the loss or blue shift of luminescence.…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, the probe was reported to react with H 2 S exclusively, and its function to differentiate various biothiols and PA imaging remains unexplored. 38 In addition, although colorimetric, fluorescent, or PA assays are commonly used for detection of biothiols, the existing methods only allow detection of a single biothiol or do not have multiple combined detection modalities (Table S1). 37,39−48 Compared with the reported strategies that allow simultaneous discrimination of biothiols, 43,44 our new probe provides a proof of concept for the differentiation of biothiols by fluorescence and ratiometric PA dual-modal imaging.…”
mentioning
confidence: 99%
“…17 Several NIR H 2 S probes have been developed and achieved great performance in H 2 S bioimaging. 18–22 Unfortunately, these probes failed to monitor the H 2 S level in cell membranes due to the poor cell membrane-targeting ability. Besides, the majority of them suffered from slow response rates, which was detrimental for the real-time recording of the concentration of H 2 S. To resolve these problems, a NIR H 2 S probe that can specifically target cell membranes and rapidly react with H 2 S was fabricated in this work.…”
mentioning
confidence: 99%