Methylene blue staining test in assessing safe margins in laryngeal papillomatosis

Abstract

Laryngeal papillomatosis, although a viral and benign disease, poses a great challenge for the ENT surgeon from a therapeutical point of view. The lack of a curative treatment and the tendency of the papillomatosis to recur in an extensive manner require an aggressive treatment. Although multiple medical therapies are available, their results are not always the desired ones. That is why nowadays the focus of the therapy is on the surgical approach. The best results may be obtained thru multiple surgeries, with resection of all papilloma foci. Although this approach may impact the quality of life of the patients due to the multiple interventions required, the overall result translates into a physiologic airway. Because the site where the lesions first appear is at an epithelial level, tendency to use methods of early diagnosis, that make the disease recognizable before extensive lesions, is the natural tendency. Also, it is extremely important to remove all papilloma lesions during surgery, thus minimizing the chances of recurrence or at least increasing the interval between interventions.The aim of this paper is to present the methylene blue staining test as an adjuvant method of evaluating the resection margins during surgery for laryngeal papillomatosis. This method can improve the results of surgery and increase the patient�s adherence to treatment, by decreasing the number of interventions required.

Intraoperative Identification of Lacrimal Sac by Means of Methylene Blue

“…Keywords: dacryocystitis, methylene blue, lacrimal sac, dacryocystectomy MB was synthesised for the first time in 1876 by Heinrich Caro at Badishe Anilin and Sado Fabrik (BASF), being used in textile dyeing [1][2][3], then 15 years later it was the first antiseptic introduced in clinical cure of malaria [1]. MB is now used in a large variety of dyes for multiple purposes and in medicine for a number of therapeutic and diagnostic procedures [2,[4][5][6][7][8][9][10].…”