Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh artery study

Fowkes, F. G. R.; Lee, A.J; Hau, C. M.; Cooke, Alexander; Connor, J. M.; Lowe, G.D.O.

doi:10.1016/s0021-9150(99)00366-4

Cited by 63 publications

(53 citation statements)

References 22 publications

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“…The genotype frequencies for eNOS4 b/b and eNOS4 a/b plus eNOS4 a/a in our study population was 77.8 and 22.2%, respectively, which were similar to those reported in the control populations of a Japanese study (80.0 and 20.0%) [11]and a UK study (77 and 23%) [12], but were different from those of an Australian control population (66.6 and 33.4%) [7]and a German control population (69 and 31%) [9]. …”

Section: Discussionsupporting

confidence: 87%

The 27-bp Tandem Repeat Polymorphism in Intron 4 of the Endothelial Nitric Oxide Synthase Gene Is Not Associated with Coronary Artery Disease in a Hospital-Based Taiwanese Population

Hwang¹,

Tsai²,

Yeh

et al. 2002

Cardiology

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We studied whether the 27 base pair (bp) tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene was associated with coronary artery disease (CAD) in a hospital-based Taiwanese population. We included 219 consecutive patients who underwent coronary angiography at our institution. Two alleles, containing 4 (eNOS4a) and 5 repeats (eNOS4b), were identified after polymerase chain reaction amplifying intron 4 of the eNOS gene. The genotype frequencies for eNOS4b/b, eNOS4a/b and eNOS4a/a were 77.9, 21.5 and 0.6% in CAD subjects, and 80, 20 and 0% in control subjects (Fisher’s exact test, p = 0.90), respectively. The odds ratio (OR) for CAD in patients with at least one eNOSa allele was 1.2 (0.5–2.9) after adjustment for classical CAD risk factors. The eNOS4a allele was not associated with the severity of CAD (Fisher’s exact test, p = 0.90) and the occurrence of acute myocardial infarction (AMI) or unstable angina (adjusted OR 0.6, 0.3–1.6) in patients with CAD. In conclusion, the 27-bp repeat polymorphism of the eNOS gene was not associated with CAD and the occurrence of AMI or unstable angina in a hospital-based Taiwanese population.

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Section: Discussionsupporting

confidence: 87%

The 27-bp Tandem Repeat Polymorphism in Intron 4 of the Endothelial Nitric Oxide Synthase Gene Is Not Associated with Coronary Artery Disease in a Hospital-Based Taiwanese Population

Hwang¹,

Tsai²,

Yeh

et al. 2002

Cardiology

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“…Another possibility is a greater genetic susceptibility to PAD in blacks. However, whereas 1 study has reported on possible genotype differences in PAD, 28 no information is currently available on ethnic differences for these genotypes. Finally, unmeasured psychosocial variables such as depression or hostility might be relevant.…”

Section: Discussionmentioning

confidence: 99%

Ethnicity and Peripheral Arterial Disease

et al. 2005

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Background-Previous studies have indicated higher rates of peripheral arterial disease (PAD) in blacks than in non-Hispanic whites (NHWs), with limited information available for Hispanics and Asians. The reason for the PAD excess in blacks is unclear. Methods and Results-Ethnic-specific PAD prevalence rates were determined in a randomly selected defined population that included 4 ethnic groups; NHWs, blacks, Hispanics, and Asians. A total of 2343 participants aged 29 to 91 years were evaluated. There were 104 cases of PAD (4.4%). In weighted logistic models with NHWs as the reference group and containing demographic factors only, blacks had a higher PAD prevalence than NHWs (ORϭ2.30, PϽ0.024), whereas PAD rates in Hispanics and Asians, although somewhat lower, were not significantly different from NHWs. Blacks had significantly more diabetes and hypertension than NHWs and a significantly higher body mass index. Inclusion of these variables and other PAD risk factors in the model did not change the effect size for black ethnicity (ORϭ2.34, Pϭ0.048). A model containing interaction terms for black ethnicity and each of the other risk factors revealed no significant interaction terms, which indicates no evidence that blacks were more "susceptible" than NHWs to cardiovascular disease risk factors. Conclusions-Black ethnicity was a strong and independent risk factor for PAD, which was not explained by higher levels of diabetes, hypertension, and body mass index. There was no evidence of a greater susceptibility of blacks to cardiovascular disease risk factors as a reason for their higher PAD prevalence. Thus, the excess risk of PAD in blacks remains unexplained and requires further study.

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“…The eNOS gene could be a candidate gene for the development of atherosclerosis, and it has been extensively studied in this condition. The Glu/Asp 298 polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the eNOS gene are the most studied polymorphisms of this gene in coronary atherosclerosis, thrombosis, and other thrombotic/ischemic conditions (10)(11)(12)(13)(14)(15)(16). Asp 298 and/or 4a polymorphisms have been found to be associated with angiographic evidence of coronary artery disease and myocardial infarction (10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…The Glu/Asp 298 polymorphism in exon 7 and the 4a/b polymorphism in intron 4 are the most studied polymorphisms of the eNOS gene under conditions in which endothelial dysfunction plays a key pathogenic role, such as in coronary atherosclerosis, thrombosis, and other ischemic/thrombotic conditions (10)(11)(12)(13)(14)(15)(16). Interestingly, a functional role has been postulated for both polymorphisms (17)(18)(19)(20).…”

mentioning

confidence: 99%

Endothelial nitric oxide synthase gene polymorphisms in giant cell arteritis

Salvarani¹,

Casali²,

Nicoli³

et al. 2003

Arthritis & Rheumatism

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Objective. To examine potential associations of the Glu/Asp 298 polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene with susceptibility to and clinical expression of giant cell arteritis (GCA), particularly in patients with versus those without ischemic complications.Methods. Ninety-one consecutive patients with biopsy-proven GCA, who were residents of Reggio Emilia, Italy, and 133 population-based controls from the same geographic area were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for eNOS polymorphisms in exon 7 and intron 4. The patients were separated into 2 subgroups according to the presence or absence of ischemic complications (visual loss and/or jaw claudication and/or aortic arch syndrome).Results. The distribution of the Glu/Asp 298 genotype differed significantly between GCA patients and controls (corrected P [P corr ] ‫؍‬ 0.003). Carriers of the Asp 298 allele (Asp/Asp or Glu/Asp) were significantly more frequent among the GCA patients than among the controls (P corr ‫؍‬ 0.0002, odds ratio 3.3, 95% confidence interval 1.7-6.3). The distribution of the 4a/b genotype was similar in GCA patients and controls. No significant associations were found when GCA patients with and without ischemic complications were compared.Conclusion. Our findings show that the Glu/ Asp 298 polymorphism of the eNOS gene is associated with GCA susceptibility.

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Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh artery study

Cited by 63 publications

References 22 publications

The 27-bp Tandem Repeat Polymorphism in Intron 4 of the Endothelial Nitric Oxide Synthase Gene Is Not Associated with Coronary Artery Disease in a Hospital-Based Taiwanese Population

The 27-bp Tandem Repeat Polymorphism in Intron 4 of the Endothelial Nitric Oxide Synthase Gene Is Not Associated with Coronary Artery Disease in a Hospital-Based Taiwanese Population

Ethnicity and Peripheral Arterial Disease

Endothelial nitric oxide synthase gene polymorphisms in giant cell arteritis

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