Methylenetetrahydrofolate Reductase C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis

Guo, Lijia

doi:10.7314/apjcp.2012.13.5.2193

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…During the past decade several meta-analyses were published assessing MTHFR as a risk factor to various cancers like-esophageal cancer,[ 66 67 ] pancreatic cancer,[ 68 69 ] liver cancer,[ 70 ] ovary cancer,[ 68 71 72 ] lung cancer,[ 73 74 ] cervical cancer,[ 76 77 ] gastric cancer,[ 34 78 ] prostate cancer[ 75 ] and head and neck cancer. [ 79 ] During the literature search seven meta-analysis on the same topic[ 45 65 80 81 82 83 84 ] were retrieved, out of which three meta-analysis investigated association between A1298C polymorphism and BC.…”

Section: Discussionmentioning

confidence: 99%

“…Heterogeneity is a very important part of a meta-analysis, and finding the possible sources for the high heterogeneity is very important and can greatly affect the results of a meta-analysis. [ 76 ] To explore the possible sources for the high heterogeneity in the present meta-analysis, subgroup analysis was performed (results not shown). By subgroup analysis author found that the ethnicity was the major source of the high heterogeneity in the present meta-analysis, which could be explained by the race-specific effect of MTHFR A1298C polymorphism on susceptibility to BC.…”

Section: Discussionmentioning

confidence: 99%

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Methylenetetrahydrofolate reductase a1298c polymorphism and breast cancer risk: A meta-analysis of 33 studies

Rai

2014

Ann Med Health Sci Res

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Methylenetetrahydrofolate reductase (MTHFR) enzyme is essential for DNA synthesis and DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and different types of cancers. Several studies have investigated the association between the MTHFR A1298C polymorphism and breast cancer (BC) risk, but the results were inconclusive. To assess the risk associated with MTHFR A1298C polymorphism, a comprehensive meta-analysis was performed. PubMed, Google Scholar, Elsevier and Springer Link databases were searched for case-control studies relating the association between MTHFR A1298C polymorphism and BC risk and estimated summary odds ratios (ORs) with confidence intervals (CIs) for assessment. Up to January 2014, 33 case-control studies involving 15,919 BC patients and 19,700 controls were included in the present meta-analysis. The results showed that the A1298C polymorphism was not associated with BC risk in all the five genetic models (C vs. A allele (allele contrast): OR = 0.99, 95% confidence interval (CI): 0.93–1.05; AC versus AA (heterozygote/codominant): OR = 0.97, 95% CI: 0.89–1.04; CC versus AA (homozygote): OR = 0.99, 95% CI: 0.91–1.06; CC + AC versus AA (dominant model): OR = 0.97, 95% CI: 0.90–1.05; and CC versus AC + AA (recessive model): OR = 0.99, 95% CI: 0.91–1.07). The present meta-analysis did not support any association between the MTHFR A1298C polymorphism and BC risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate reductase a1298c polymorphism and breast cancer risk: A meta-analysis of 33 studies

Rai

2014

Ann Med Health Sci Res

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“…Morbidity, mortality and long-term complications of these infections are increasing public health concerns worldwide [1,14,17,18,[25][26][27][28][29][30]. Several studies have reported that the frequency of SNPs is different in communities and races; for instance, MTHFR 677 TT, CC and CT genotype frequencies in the following populations are as follows: East Asians, India, Mexico, Poland and Netherlands [29][30][31][32][33]. In our study, CC = 27, CT = 11 and TT = 0 were calculated for MTHFR C677T, which are nearly similar to this study such as East Asians, Germany, Poland and India [33], and some of the published articles are not similar to this result which are obtained from the USA, China and Denmark [16,[30][31][32].…”

Section: Discussionmentioning

confidence: 99%

The Impact of MTHFR 1298 A > C and 677 C > T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections

Sohrabi

Bassam-Tolami

Imani

2020

J Obstet Gynecol India

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Background HPV genotypes are the most common etiological factor for genital neoplasia. It would appear that sexually transmitted infections accompanied with HPV genotypes might have synergistic interactions in cancer progression. The genetic polymorphisms are involved in metabolizing carcinogens which may contribute to the susceptibility of developing genital cancers by less efficient or overly down metabolic pathways and cell signaling. MTHFR polymorphisms are related to several metabolic disorders and human cancers. We investigated the contribution of MTHFR 1298 and MTHFR 677 polymorphisms as potential risk factors for outcomes with HPV genotypes and STIs in Iranian population. Materials and Methods As a case-control study, MTHFR A1298C and C677T were assessed for SNPs analysis using a PCR-RFLP assay in 50 cervical intraepithelial neoplasia (CIN) cases, 98 HPV-positive subjects and 47 non-cancerous/ non-HPV patients as healthy controls. Results Finding suggested a significant association between the MTHFR 1298 CC polymorphisms (OR = 3.5, 95% CI = 1.13-10.82, P ≤ 0.05) in women with CIN as compared to non-cancerous/non-HPV subjects. There was not a significant difference of MTHFR 677 between outcomes. Discussion It would seem MTHFR 1298 CC is more likely to be a potential risk factor for HPV-cervical cancer progression. Consequences support further attempts to understand the clinical manifestations of neoplasia related to genital infections and gene mutations.

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“…Meta-analyses observed that C677T MTHFR polymorphism may be associated with cervical carcinogenesis in a different way according to ethnicity. This SNP was considered risk factor for cervical cancer among Asiatic women, but protection factor for Caucasian [13,14,35,36].…”

Section: Discussionmentioning

confidence: 99%

Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women

Silva¹,

Sabino²,

Tafuri³

et al. 2019

BMC Med Genet

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Background: Cervical cancer has high prevalence and mortality rates in worldwide female population. Persistent infection by high-risk Human Papillomavirus (hr-HPV) is the main cause of this cancer. However, many environmental, genetical, and epigenetical cofactors can modulate viral infection and cervical carcinogenesis. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a genetic factor that has been associated with many pathologies, including cancer. Nevertheless, studies with cervical cancer presented controversial results, and varied according to ethnicity. Thus, the aim of this study was to determine association between MTHFR C677T polymorphism, Human Papillomavirus (HPV) infection and cervical cancer. Methods: A case-control study was performed with 150 histological cervical samples. Case group were divided in Cervical Intraepithelial Neoplasia (CIN) grade I (n = 30), CIN II (n = 30), CIN III (n = 30), and Squamous Cervical Carcinoma (SCC) (n = 30). Control group was composed by 30 samples without lesion, presenting cervicitis. HPV detection was performed by conventional Polymerase Chain Reaction (PCR) with SPF primers set, and by real-time PCR specific for HPV 16 and hr-HPV. MTHFR C677T polymorphism was analyzed by PCR followed by Restriction Fragment Length Polymorphism (RFLP). Results: Frequency of MTHFR CC genotype was 72.7% (n = 109), CT 23.3% (n = 35) and TT 4.0% (n = 6). Polymorphic T allele frequency was 15.7%. No statistically significant association was observed between MTHFR C677T polymorphism and presence of pre-neoplastic or neoplastic cervical lesions. Similar frequencies of T allele was observed in control (23.3%) and cases (13.3%) groups (p = 0.174). In addition, there was no statistically significant association between MTHFR C677T polymorphism and viral infection, even considering hr-HPV or HPV 16 positivity. Conclusion: MTHFR C677T polymorphism was not associated with cervical cancer and HPV infection.

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Methylenetetrahydrofolate Reductase C677T Polymorphism and Cervical Cancer Risk: a Meta-Analysis

Cited by 6 publications

References 38 publications

Methylenetetrahydrofolate reductase a1298c polymorphism and breast cancer risk: A meta-analysis of 33 studies

Methylenetetrahydrofolate reductase a1298c polymorphism and breast cancer risk: A meta-analysis of 33 studies

The Impact of MTHFR 1298 A > C and 677 C > T Gene Polymorphisms as Susceptibility Risk Factors in Cervical Intraepithelial Neoplasia Related to HPV and Sexually Transmitted Infections

Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women

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