Methylhistamine in Crohn's disease (CD): Increased production and elevated urine excretion correlates with disease activity

Weidenhiller, Michael; Raithel, Martin; Winterkamp, Sandra; Otte, P; Stolper, Jennifer; Hahn, Eckhart G.

doi:10.1007/pl00000171

Cited by 18 publications

(14 citation statements)

References 5 publications

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“…The uniform inhibition of responses to PAR-1 in all treatment groups indicates that the effect is not specific to inflammation but may be a generalized response to CD4 ϩ T-cell-mediated immune activation. Histamine is one of many mast cell products, and increased levels of histamine and its metabolites are reported in active IBD (27,43,57,58). Much of the effect of histamine on epithelial cell secretion is mediated by H1R.…”

Section: Vol 76 2008 Anti-inflammatory Effects Of H Polygyrus On Cmentioning

confidence: 99%

Anti-Inflammatory Mechanisms of EntericHeligmosomoides polygyrusInfection against Trinitrobenzene Sulfonic Acid-Induced Colitis in a Murine Model

et al. 2008

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Recent studies showed that enteric helminth infection improved symptoms in patients with inflammatory bowel disease as well as in experimental models of colitis. The aim of this study was to determine the mechanism of the protective effect of helminth infection on colitis-induced changes in immune and epithelial cell function. BALB/c mice received an oral infection of Heligmosomoides polygyrus third-stage larvae, were given intrarectal saline or trinitrobenzene sulfonic acid (TNBS) on day 10 postinfection, and were studied 4 days later. Separate groups of mice received intrarectal saline or TNBS on day 10 and were studied on day 14. Muscle-free colonic mucosae were mounted in Ussing chambers to measure mucosal permeability and secretion.

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Section: Vol 76 2008 Anti-inflammatory Effects Of H Polygyrus On Cmentioning

confidence: 99%

Anti-Inflammatory Mechanisms of EntericHeligmosomoides polygyrusInfection against Trinitrobenzene Sulfonic Acid-Induced Colitis in a Murine Model

et al. 2008

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“…The highly elevated mucosal histamine levels were also observed in patients with allergic enteropathy and ulcerative colitis [27] . Moreover, enhanced histamine metabolism was found in patients with collagenous colitis and food allergy [92] , and increased level of N-methylhistamine, a stable metabolite of the mast cell mediator histamine, was detected in the urine of patients with active Crohn's disease or ulcerative colitis [93,94] . Since increased level of N-methylhistamine was significantly correlated to clinical disease activity, the above finding further strongly suggested the active involvement of histamine in the pathogenesis of these diseases.…”

Section: Involvement Of Histamine In Pathogenesis Of Ibdmentioning

confidence: 99%

Key role of mast cells and their major secretory products in inflammatory bowel disease

He¹

2004

WJG

227

173

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Historically, mast cells were known as a key cell type involved in type I hypersensitivity. Until last two decades, this cell type was recognized to be widely involved in a number of non-allergic diseases including inflammatory bowel disease (IBD). Markedly increased numbers of mast cells were observed in the mucosa of the ileum and colon of patients with IBD, which was accompanied by great changes of the content in mast cells such as dramatically increased expression of TNFα, IL-16 and substance P. The evidence of mast cell degranulation was found in the wall of intestine from patients with IBD with immunohistochemistry technique. The highly elevated histamine and tryptase levels were detected in mucosa of patients with IBD, strongly suggesting that mast cell degranulation is involved in the pathogenesis of IBD. However, little is known of the actions of histamine, tryptase, chymase and carboxypeptidase in IBD. Over the last decade, heparin has been used to treat IBD in clinical practice. The low molecular weight heparin (LMWH) was effective as adjuvant therapy, and the patients showed good clinical and laboratory response with no serious adverse effects. The roles of PGD2, LTC4, PAF and mast cell cytokines in IBD were also discussed. Recently, a series of experiments with dispersed colon mast cells suggested there should be at least two pathways in man for mast cells to amplify their own activationdegranulation signals in an autocrine or paracrine manner. The hypothesis is that mast cell secretogogues induce mast cell degranulation, release histamine, then stimulate the adjacent mast cells or positively feedback to further stimulate its host mast cells through H 1 receptor. Whereas released tryptase acts similarly to histamine, but activates mast cells through its receptor PAR-2. The connections between current anti-IBD therapies or potential therapies for IBD with mast cells were discussed, implicating further that mast cell is a key cell type that is involved in the pathogenesis of IBD. In conclusion, while pathogenesis of IBD remains unclear, the key role of mast cells in this group of diseases demonstrated in the current review implicates strongly that IBD is a mast cell associated disease. Therefore, close attentions should be paid to the role of mast cells in IBD.He SH. Key role of mast cells and their major secretory products in inflammatory bowel disease.

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“…In contrast to IgE, urinary excretion of N-methylhistamine showed no age-dependent differences in a healthy adult population, when standardised urine collection and evaluation criteria are used (diet, renal function, BSA) [2,3]. This result indicates a stable histamine production and metabolism in healthy adults with increasing age (Fig.…”

Section: Resultsmentioning

confidence: 76%

“…The patients received an unrestricted diet, only avoiding typical histamine rich food [2], from 8 a. m. to 2 p. m. on two successive days. Subsequently, urine samples were collected on these two days over a period of 12 h (6 p. m. to 6 a. m.) [2,3]. 1 N HCL was added to the urine samples to avoid bacterial histamine production.…”

Section: Methodsmentioning

confidence: 99%

“…Intra-individual variation of N-methylhistamine was 21.6 ± 16.3 %. Since urinary excretion of N-methylhistamine may be influenced by renal function, weight and body seize, urine N-methylhistamine values were related to creatinine excretion (Beckman creatinine analyzer 2) [2,3,4], and concentrations of N-methylhistamine were expressed as mg/mmol creatinine ¥ m 2 body surface area (BSA) [2,3,5]. Serum creatinine was below 1.4 mg/dl in all patients.…”

Section: Methodsmentioning

confidence: 99%

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Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population

Winterkamp

Weidenhiller

Wilken

et al. 2003

Inflammation Research

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IntroductionAllergy frequency is still increasing in industrial countries, but monitoring of allergic and inflammatory conditions may be difficult. The incidence of allergy and elevated IgE serum levels has been reported to decrease with age.The measurement of urinary excretion of N-tele-methylhistamine is a valuable diagnostic tool to monitor disease activity in allergic or inflammatory conditions (e. g. food allergy, inflammatory bowel diseases, microscopic colitis), but there are only rare data on histamine production and excretion in different periods of age in a healthy adult population [1]. Materials and methodsUrinary excretion of N-tele-methylhistamine was measured under standardised conditions in a healthy population of 54 adults (32 women, 22 men, mean age 45 ± 14 years, range 16 -72 years) without any medication [2]. Allergic, inflammatory or neoplastic diseases were excluded by allergy tests, endoscopy, histology and serology. The patients received an unrestricted diet, only avoiding typical histamine rich food [2], from 8 a. m. to 2 p. m. on two successive days. Subsequently, urine samples were collected on these two days over a period of 12 h (6 p. m. to 6 a. m.) [2,3]. 1 N HCL was added to the urine samples to avoid bacterial histamine production.Urinary methylhistamine was measured by RIA (Pharmacia) [2, 3] with intra-and interassay variations of 12.5 and 14.5 %. Intra-individual variation of N-methylhistamine was 21.6 ± 16.3 %. Since urinary excretion of N-methylhistamine may be influenced by renal function, weight and body seize, urine N-methylhistamine values were related to creatinine excretion (Beckman creatinine analyzer 2) [2, 3, 4], and concentrations of N-methylhistamine were expressed as mg/mmol creatinine ¥ m 2 body surface area (BSA) [2, 3, 5]. Serum creatinine was below 1.4 mg/dl in all patients.The mean value of the individual methylhistamine excretion was calculated from the excretion rates obtained at day 1 and 2. Results and discussionUrinary concentrations of N-methylhistamine showed a Gaussian distribution, with no significant differences between sex (males: 5.2 ± 2.3 mg/mmol creatine ¥ m 2 BSA; females: 4.3 ± 1.6 mg/mmol creatine ¥ m 2 BSA) and different age groups.Interestingly, urinary methylhistamine was found to be relatively stable between 4.0 and 5.2 mg/mmol creatinine ¥ m 2 BSA (± SD 1.3 -2.4) in different age groups (Fig. 1).In contrast to IgE, urinary excretion of N-methylhistamine showed no age-dependent differences in a healthy adult population, when standardised urine collection and evaluation criteria are used (diet, renal function, BSA) [2,3]. This result indicates a stable histamine production and metabolism in healthy adults with increasing age (Fig. 1) and it seems to be more modulated by allergic and inflammatory conditions, concomitant medication or disease and nutrition. There is only rare information about the relation of histamine metabolism and age. Oosting et al. found an age dependency Inflamm. res. 52, Supplement 1 (2003) Fig. 1. Urinary N-tele-methyl...

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Methylhistamine in Crohn's disease (CD): Increased production and elevated urine excretion correlates with disease activity

Cited by 18 publications

References 5 publications

Anti-Inflammatory Mechanisms of EntericHeligmosomoides polygyrusInfection against Trinitrobenzene Sulfonic Acid-Induced Colitis in a Murine Model

Anti-Inflammatory Mechanisms of EntericHeligmosomoides polygyrusInfection against Trinitrobenzene Sulfonic Acid-Induced Colitis in a Murine Model

Key role of mast cells and their major secretory products in inflammatory bowel disease

Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population

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