Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study

Yazar, Kerem; Lundov, Michael D.; Faurschou, Annesofie; Matura, Mihály; Boman, Anders; Johansen, Jeanne Duus; Lidén, Carola

doi:10.1111/bjd.13751

Cited by 42 publications

(42 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 The fields of exposure beyond cosmetics need to be addressed also, in terms of lowering MI use concentration levels, comprising household/cleaning, technical and, in fact, all products. Moreover, as it has been stated that 15 ppm MI may not be suitable for preservation, at least if used alone, MI may actually have been replaced by other preservatives in rinse-off cosmetic products.…”

Section: Shift In Types Of Products Eliciting Allergic Contact Dermatmentioning

confidence: 99%

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

Uter

Aalto‐Korte

Agner

et al. 2019

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

Background Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action has been taken, at least in Europe, aiming at reducing risk of MI sensitization. Objective To follow‐up on the prevalence of contact allergy to MI in consecutively patch tested patients and assess the spectrum of products containing MI or methylchloroisothiazolinone (MCI)/MI in patients positive to MI which elicited current allergic contact dermatitis. Methods A cross‐sectional survey was performed in 2016 and 2017, including all adult patients patch tested with the baseline series (including MI 0.2% aq.) between 1 May and 31 October at 14 centres in 11 European countries. Patients with positive reactions (+ to +++) to MI were further examined regarding history, clinical characteristics and eliciting products, which were categorized into 34 types and 4 classes (leave‐on, rinse‐off, household, occupational). The results were compared with the reference year 2015. Results A total of 317 patients, n = 202 of 4278 tested in 2016 (4.72%) and n = 115 of 3879 tested in 2017 (2.96%), had positive reactions to MI; the previous result from 2015 was 5.97% (P < 0.0001). The share of currently relevant contact allergy among all positive reactions declined significantly as well (P = 0.0032). Concerning product classes, a relative decline of leave‐on and a relative increase of rinse‐off and household products was noted. Conclusion The prevalence of MI contact allergy decreased by 50% from 2015 to 2017. As a consequence of regulation, the share of cosmetics products (leave‐on in particular) eliciting allergic contact dermatitis is decreasing. The chosen method of analysing causative products in sensitized patients has proven useful to monitor effects of intervention.

show abstract

Section: Shift In Types Of Products Eliciting Allergic Contact Dermatmentioning

confidence: 99%

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

Uter

Aalto‐Korte

Agner

et al. 2019

Acad Dermatol Venereol

Self Cite

View full text Add to dashboard Cite

show abstract

“…This has clearly been exemplified by the introduction of MI into the European cosmetic market in 2005 where MI was given a positive opinion by the SCCS and entered onto Annex V as a preservative allowed for use in cosmetic products. The rapid increase of MI contact allergy has greatly contributed to the overall burden of contact allergy to preservatives, and thousands of European citizens most likely experience allergic contact dermatitis when being in skin contact with cosmetic products preserved with MI or when being exposed to evaporated MI from newly painted rooms [17][18][19].…”

Section: Temporal Trend Of Contact Allergy To Preservativesmentioning

confidence: 99%

“…The cosmetic industry asked the EC to re-evaluate this opinion, as the industry claimed that a maximum concentration of 100 ppm MI in rinse-off cosmetic products was safe for the European consumer [53]. A recent Swedish clinical study did, however, show that the use of MI in rinse-off cosmetic products containing MI in concentrations of 100 ppm indeed did elicit contact dermatitis in patients with an MI contact allergy [19]. In July 2015, the SCCS concluded in their final re-assessment of the sensitizing potential of MI that the use of MI in rinse-off cosmetic products and leave-on hair care products should not exceed 15 ppm [53].…”

Section: Contact Allergy To Methylisothiazolinonementioning

confidence: 99%

Contact Allergy to Preservatives—Is the European Commission a Commendable Risk Manager?

Schwensen

Thyssen

2016

Cosmetics

View full text Add to dashboard Cite

Abstract:Although preservatives are necessary to prevent deterioration by microbial growth in cosmetic products, daily skin contact with preserved cosmetic products may cause a preservative contact allergy. Only preservatives with sufficient pre-market risk assessment, presumably being safe for the consumer from a public health point of view, are permitted for use in cosmetic products in the European Union. Notwithstanding the efforts by the European Commission (EC) to avoid epidemics of contact allergy, the former epidemic of contact allergy to methyldibromo glutaronitrile and the unprecedented epidemic of contact allergy to methylisothiazolinone show the procrastination of the European Union risk management process for cosmetic ingredients. Timely risk management is of the utmost importance to avoid rapidly increasing numbers of contact allergy to turn into full-blown epidemics. It is therefore proposed that in order to avoid future epidemics of contact allergy to preservatives, the allowed preservatives in cosmetic products should be entered onto Annex V on a time-limited basis only, and they must be re-evaluated in order to stay on Annex V.

show abstract

“…In the article by Yazar et al , there was a typographical error in the text. On page 116, Confirmatory patch test section, first paragraph, line 11, it should have been 15 μL (instead of mL).…”

mentioning

confidence: 99%

Corrigendum

2017

Br J Dermatol

View full text Add to dashboard Cite

Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study

Abstract: Rinse-off products preserved with 50 ppm MI or more are not safe for consumers. No safe level has yet been identified.

Cited by 42 publications

References 32 publications

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

The epidemic of methylisothiazolinone contact allergy in Europe: follow‐up on changing exposures

Contact Allergy to Preservatives—Is the European Commission a Commendable Risk Manager?

Corrigendum

Contact Info

Product

Resources

About