Methylisothiazolinone in selected consumer products in Belgium: Adding fuel to the fire?

Aerts, Olivier; Meert, Hans; Goossens, An; Janssens, S.; Lambert, Julien; Apers, Sandra

doi:10.1111/cod.12449

Cited by 46 publications

(67 citation statements)

References 27 publications

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“…Nevertheless, leave‐on products with MI exceeding the legal limits were also reported by Aerts et al and Neza and Cetini , and represent a serious concern. The MCI concentrations in cosmetics were relatively low, with an average value of 4.8 ppm, which is comparable to the most recent studies in Belgium, Spain, and the United States . As expected, the MI concentrations (average value of 58 ppm) were higher than those of MCI in cosmetics, and these findings are comparable with those of , but higher than those of , in which a sample of five shampoos had been investigated.…”

Section: Discussionsupporting

confidence: 83%

“…The MCI concentrations in cosmetics were relatively low, with an average value of 4.8 ppm, which is comparable to the most recent studies in Belgium, Spain, and the United States . As expected, the MI concentrations (average value of 58 ppm) were higher than those of MCI in cosmetics, and these findings are comparable with those of , but higher than those of , in which a sample of five shampoos had been investigated. The results of Alvarez‐Rivera et al are comparable for rinse‐off products but not for leave‐on products, which showed higher MI concentrations in Switzerland (average of 98 ppm) than in Spain (average of 7.2 ppm).…”

Section: Discussionsupporting

confidence: 83%

“…They found both MCI and MI in low concentrations (average of 5.9 ppm for MCI and 7.5 ppm for MI), whereas our study shows much higher concentrations of MI (44 ppm on average) than of MCI (6.9 ppm), because many more products contained MI. Nevertheless, high concentrations of MI were also found by Aerts et al . This Belgian survey indicated that MI had the highest concentrations (average value of 97 ppm), and also was the most frequently found isothiazolinone.…”

Section: Discussionmentioning

confidence: 61%

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Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

et al. 2016

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SummaryBackground. In recent years, the frequency of contact allergy to isothiazolinones has increased alarmingly in Europe, but only limited data are available on concentrations of isothiazolinones in consumer products. Objectives. To examine the current frequency of isothiazolinones [methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT)] in a wide array of detergents and cosmetics relevant for the Swiss population. Methods. By means of a market survey, the occurrence of isothiazolinones was investigated in 1948 consumer products. Of these, 88 products were analysed by liquid chromatography-high-resolution mass spectrometry after ultrasonic extraction. Results. Only 7.6% of all cosmetics contained isothiazolinones, but the prevalence in detergents was much higher (42.9%). The measured concentration ranges in detergents were 4.3-10, 3.5-279, 3.8-186 and 7.9 ppm (one product only) for MI, MCI, BIT, and OIT, respectively. For cosmetics, these were 1.3-133 and 4.8 ppm (one product only) for MI and MCI, respectively. Conclusions. Our study has shown that high concentrations of isothiazolinones (including MI) can be found in a large variety of products, in particular in detergents. Therefore, the safe use of these preservatives should be re-evaluated by including detergents in the exposure assessment.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 61%

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Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

et al. 2016

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“…Briefly, 5 ml of the gel mask was dissolved in 20 ml of physiological saline, and this aqueous solution was subsequently used for the spot test. Four other cosmetics, that is, three positive controls containing MI, and one negative control free from MI that had been previously investigated by the use of high‐performance liquid chromatography with ultraviolet detection (HPLC‐UV) , were all correctly identified with regard to their MI content by use of this experimental detection method.…”

Section: Case Reportmentioning

confidence: 99%

Facial dermatitis caused by undeclared methylisothiazolinone in a gel mask: is the preservation of raw materials in cosmetics a cause of concern?

Kerre¹,

Naessens

Theunis

et al. 2018

Contact Dermatitis

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“…While EU legislation restricts the maximum concentration of isothiazolinones in cosmetics, and imposes adequate labelling of cosmetics and domestic products, several publications have reported MI exceeding 100 ppm, the maximum permitted concentrations, mislabelling or absent information concerning the use of either MCI/MI or MI in several products, and in cosmetics regarded as ‘natural’ …”

Section: Labellingmentioning

confidence: 99%

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Herman

Aerts

Montjoye

et al. 2019

Acad Dermatol Venereol

112

115

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Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in the 1980s, and more recently to MI, the Scientific Committee on Consumer Safety of the European Commission banned their use in leave‐on products, while restricting that in rinse‐off cosmetics. Despite a decreasing prevalence of ACD from MCI/MI and MI, cases caused by occupational exposure and non‐cosmetic isothiazolinone sources are on the rise. Moreover, sensitization to newer and lesser known isothiazolinones has been reported. This paper reviews the epidemiology of contact allergy to different isothiazolinones, clinical presentation of isothiazolinone‐induced ACD, most relevant sensitization sources and potential cross‐reactions between isothiazolinone derivatives. It also provides an update on recent legislative measures.

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Methylisothiazolinone in selected consumer products in Belgium: Adding fuel to the fire?

Abstract: Cosmetics and detergents may facilitate contact sensitization because of a (too) high MI concentration, and mislabelling may make its avoidance extremely difficult. Safer use concentrations and correct labelling should be ensured by adequate quality control.

Cited by 46 publications

References 27 publications

Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland

Facial dermatitis caused by undeclared methylisothiazolinone in a gel mask: is the preservation of raw materials in cosmetics a cause of concern?

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

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