Methylmercury Induced Neurotoxicity and the Influence of Selenium in the Brains of Adult Zebrafish (Danio rerio)

Rasinger, Josef Daniel; Lundebye, Anne‐Katrine; Penglase, Samuel; Ellingsen, Ståle; Amlund, Heidi

doi:10.3390/ijms18040725

Cited by 36 publications

(28 citation statements)

References 43 publications

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“…Omics analyses allow for experiments which can implicate molecular networks affected by chemicals and help elucidating molecular initiating and key events in adverse outcome pathways [56]. Omics profiling is performed without prior hypothesis and is often considered as unbiased and discovery driven [3,57]. DIGE based proteomics analysis after exposure to HBCD, CB-153 and TCDD at the LD level (present study) induced dysregulation of three (HSPA8, G6PD and SIRT2), one (G6PD) and four (G6PD, TUB2A, ACTB and RALA) proteins, respectively.…”

Section: Effects On Murine Brain Gene and Protein Expression Levelsmentioning

confidence: 99%

Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice

Rasinger

Carroll

Maranghi

et al. 2018

Reproductive Toxicology

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Developmental health risks of chronical exposure to low doses of foodborne persistent organic pollutants (POP) are recognized but still largely uncharacterized. Juvenile female BALB/c mice exposed to either HBCD, CB-153 or TCDD at doses relevant to human dietary exposures (49.5 μg, 1.35 μg and 0.90 ng kg bw day, respectively) for 28 days displayed histopathological changes in liver (HBCD, CB-153, TCDD), thymus (HBCD, CB-153) and uterus (HBCD), reduced serum oestradiol 17β (E2) levels (HBCD), increased serum testosterone (T) levels (CB-153) and an increased T/E2 ratio (HBCD). Proteomics analysis of brain provided molecular support for the HBCD-induced reduction in E2. Neural gene expression analysis, confirmed effects on 18 out of 30 genes previously found to be affected after exposure to higher doses to the same pollutants. Our findings indicate that exposure to POP at low doses is associated with subtle, but toxicological relevant effects on post-natal development in female mice.

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Section: Effects On Murine Brain Gene and Protein Expression Levelsmentioning

confidence: 99%

Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice

Rasinger

Carroll

Maranghi

et al. 2018

Reproductive Toxicology

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show abstract

“…There is also conflicting and inconsistent evidence on the protective role of micronutrients, such as Se in organic compounds (mostly selenomethionine and selenocysteine) in fish eaters regarding the Hg exposure-related neurotoxic effects in humans. Mechanisms for the interaction of Hg and Se were proposed [ 126 , 127 , 128 ] but are generally not yet fully understood; hence further studies are required [ 22 , 58 , 129 , 130 , 131 , 132 ].…”

Section: Discussionmentioning

confidence: 99%

Mercury Exposure Assessment in Mother–Infant Pairs from Continental and Coastal Croatia

et al. 2020

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The main source of mercury (Hg) exposure in the general population is fish. Another possible source is dental amalgam. Here, we compare the levels of Hg and selenium (Se) in samples of maternal and fetal origin collected shortly after childbirth of healthy postpartum women in the coastal (n = 96) and continental (n = 185) areas of Croatia related to maternal seafood/fish consumption. We also evaluated Hg concentrations and maternal serum metallothionein (MT2) concentrations in relation to the number of dental amalgam fillings, and MT2A-5A/G (rs28366003) polymorphism. The levels of Hg and Se in maternal hair and blood/serum, placenta and cord blood/serum increased in relation to increasing fish consumption with the highest values in subjects from the coast. The concentrations of each element and between elements correlated across the matrices. Increasing amalgam number correlated linearly with increased Hg levels in maternal and cord serum and was not associated with serum MT2. No association of MT2A-5A/G polymorphism and Hg or Se levels were found. The results confirmed higher fish consumption in coastal vs. continental Croatia and increases of both Hg and Se related to fish consumption in all analyzed samples. Increased blood Hg reflected the predominant MeHg share from seafood, while increased serum Hg matched exposure from dental amalgams.

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“…Duration of wing flapping of male flies decreased in a MeHg concentration-dependent manner, suggesting that desire for copulation in male and female flies decreases as the concentration of MeHg increases. Since neurons and neuronal circuitry play important roles in the sexual functions [ 36 , 37 ], and MeHg induces neurotoxicity [ 38 ], it is possible that MeHg-induced sexual dysfunction is because of its neurotoxic effect.…”

Section: Discussionmentioning

confidence: 99%

Methylmercury Exposure Induces Sexual Dysfunction in Male and Female Drosophila Melanogaster

Chauhan¹,

Srikumar²,

Aamer³

et al. 2017

IJERPH

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Mercury, an environmental health hazard, is a neurotoxic heavy metal. In this study, the effect of methylmercury (MeHg) exposure was analyzed on sexual behavior in Drosophila melanogaster (fruit fly), because neurons play a vital role in sexual functions. The virgin male and female flies were fed a diet mixed with different concentrations of MeHg (28.25, 56.5, 113, 226, and 339 µM) for four days, and the effect of MeHg on copulation of these flies was studied. While male and female control flies (no MeHg) and flies fed with lower concentrations of MeHg (28.25, 56.5 µM) copulated in a normal manner, male and female flies exposed to higher concentrations of MeHg (113, 226, and 339 µM) did not copulate. When male flies exposed to higher concentrations of MeHg were allowed to copulate with control female flies, only male flies fed with 113 µM MeHg were able to copulate. On the other hand, when female flies exposed to higher concentrations of MeHg were allowed to copulate with control male flies, none of the flies could copulate. After introduction of male and female flies in the copulation chamber, duration of wing flapping by male flies decreased in a MeHg-concentration-dependent manner from 101 ± 24 seconds (control) to 100.7 ± 18, 96 ±12, 59 ± 44, 31 ± 15, and 3.7 ± 2.7 seconds at 28.25, 56.5, 113, 226, and 339 µM MeHg, respectively. On the other hand, grooming in male and female flies increased in a MeHg-concentration-dependent manner. These findings suggest that MeHg exposure causes sexual dysfunction in male and female Drosophila melanogaster. Further studies showed that MeHg exposure increased oxidative stress and decreased triglyceride levels in a concentration–dependent manner in both male and female flies, suggesting that MeHg-induced oxidative stress and decreased triglyceride levels may partly contribute to sexual dysfunction in fruit flies.

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Methylmercury Induced Neurotoxicity and the Influence of Selenium in the Brains of Adult Zebrafish (Danio rerio)

Cited by 36 publications

References 43 publications

Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice

Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice

Mercury Exposure Assessment in Mother–Infant Pairs from Continental and Coastal Croatia

Methylmercury Exposure Induces Sexual Dysfunction in Male and Female Drosophila Melanogaster

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