Methylmethacrylate Plasma Levels During Total Hip Arthroplasty

Gentil, B.; Paugam, Charles; Wolf, Claude; Lienhart, A; Augereau, B

doi:10.1097/00003086-199302000-00018

Cited by 21 publications

(6 citation statements)

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“…The in vivo situation is likely to allow a certain degree of clearance and removal of such unreacted monomers from the site of implantation and therefore reduce the potential effects. It has been said that MMA is cleared within minutes in humans 34…”

Section: Discussionmentioning

confidence: 99%

Osteoblast cell death on methacrylate polymers involves apoptosis

Gough

Downes

2001

J. Biomed. Mater. Res.

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The success of an implant depends on the implant-tissue interface. There are many causes of implant failure, one of which is tissue necrosis. The aim of this in vitro study was to determine whether cell death of primary human osteoblasts (implant site specific cells) occurred by apoptosis (a form of programmed cell death) on two methacrylate polymers. Cells were cultured on poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate and poly(methyl methacrylate in the form of 13-mm discs, in conditioned medium containing leachable monomer and in the presence of various concentrations of monomer itself in the culture medium. It was found that monomer and leached monomer caused apoptosis of human osteoblast cells in this system. Tetrahydrofurfuryl methacrylate monomer was found to be more toxic than currently used monomer methylmethacrylate. Preincubation of polymers in serum containing medium was found to increase the biocompatibility of the polymers. High levels of apoptosis occurred on polymer used directly after polymerization. Apoptosis levels were decreased after polymer was incubated at 60 degrees C overnight or for 3 days. Apoptosis therefore may occur in cells at the implant site in vivo.

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Section: Discussionmentioning

confidence: 99%

Osteoblast cell death on methacrylate polymers involves apoptosis

Gough

Downes

2001

J. Biomed. Mater. Res.

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“…Other problems with PMMA cement include the biological response (Thomson et al 1992), leakage of the monomer of methylmethacrylate (Gentil et al 1993) and a high curing temperature (Leeson and Lippitt 1993) which damages cell activity (Jones and Hungerford 1987). In addition, the wear debris from high-density polyethylene (HDP), PMMA cement and metal may be taken up by macrophages in fibrous tissue (Willert, Bertram and Buchorn 1990;Manley and Serekian 1994;Shanbhag et al 1994).…”

mentioning

confidence: 99%

Intercalary Replacement of Canine Femora Using a New Bioactive Bone Cement

Senaha

Nakamura

Tamura

et al. 1996

The Journal of Bone and Joint Surgery. British volume

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W e have developed a bioactive bone cement (BA cement) consisting of Bis-GMA resin and bioactive glass powder. It has high compressive and tensile strengths, a low curing temperature and its bioactivity allows it to bond directly with bone.We operated on the 18 femora of nine mongrel dogs for intercalary replacement of part of the bone by a metal prosthesis using either PMMA cement or BA cement for fixation. Three dogs were killed at each of 4, 12 and 26 weeks after surgery for the evaluation of fixation strength by a push-out test and for histological examination by Giemsa surface staining and SEM.Fixation strengths with PMMA cement at 4, 12 and 26 weeks after surgery were 46.8 ± 18.9, 50.0 ± 24.7, and 58.2 ± 28.9 kgf (mean ±SD), respectively. Those with BA cement were 56.8 ± 26.1, 67.2 ± 19.2, and 72.8 ± 22.2 kgf, respectively. Fibrous tissue intervened between bone and PMMA cement but BA cement had bonded directly to bone at 12 and 26 weeks. This suggests that BA cement will be useful in providing long-lasting fixation of implants to bone under weight-bearing conditions.

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“…However, there is a possible correlation with these complications when large amounts of unbound monomer are applied to a large bone surface area or a 'plunger' effect results in fat embolism [18][19][20]. In addition, MMA has been reported to be detectable in both plasma and breast milk following joint surgery, and considering its widespread use, MMA has a low incidence of associated complications [21,22]. The primary problem reported with MMA implants in regions other than facial bones is infection, with rates near 20% at 1 to 2 years after implantation [23][24][25].…”

Section: Discussionmentioning

confidence: 99%