Methylobacterium bacteremia in AIDS

Infections Caused by Unusual Methylobacterium Species

“…Methylobacterium species have been reported to cause contamination and colonization and have been isolated from some sterile clinical sites, including blood, bone marrow, sputum, pleural effusion, peritoneal fluid, cerebrospinal fluid, synovium, and skin (2, 5, 7-9, 11, 13, 14, 16). Most Methylobacterium infections develop in immunocompromised patients, such as patients with malignancy, organ transplant, HIV infection, renal failure, or alcoholism (5,8,11,14,17). In the present study, we describe six cases of bacteremia caused by various Methylobacterium species, all of which were confirmed by 16S rRNA.…”

Isolation and Identification of Methylobacterium Species from the Tap Water in Hospitals in Japan and Their Antibiotic Susceptibility

“…The isolation of Methylobacterium species from clinical materials has been known from the past (9). Because Methylobacterium-associated sepsis has recently been noted occasionally in AIDS patients (20) and bone marrow-transplanted patients (2), it has attracted attention as an etiological agent of opportunistic infection (19). Thus, information on the drug sensitivity of clinical isolates is important for therapy.…”

A Case Report of Methylobacterium radiotolerans Bacteremia and Brain Abscesses

“…M. radiotolerans has been reported as an opportunistic pathogen of low virulence, and in humans is considered pathogenic. Most human infections related to M. radiotolerans have been reported in immunocompromised hosts such as in patients with malignancy, organ transplant, human immunodeficiency virus infection, renal failure, or alcohol abuse 6–9 . Most reported M. radiotolerans infections were nosocomial bloodstream infections and the majority were related to central venous catheters.…”