Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD)

Baker, Brennan H.; Wu, Haotian; Laue, Hannah E.; Boivin, Amélie; Gillet, Virginie; Langlois, Marie‐France; Bellenger, Jean‐Philippe; Baccarelli, Andrea A.; Takser, Larissa

doi:10.1016/j.envint.2020.105716

Cited by 51 publications

(27 citation statements)

References 54 publications

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“…In this cohort, we have previously shown an association of prenatal acetaminophen with increased odds for ADHD, 22 and associations of ADHD with adverse birth outcomes including preterm birth and lower birthweight. 27 Here, we additionally assessed whether birth outcomes mediated the relationship between prenatal acetaminophen exposure and ADHD, in separate models for each birth outcome, using the 'mediation' R package, 42 which implements a quasi-Bayesian Monte Carlo method with 1,000 simulations. To test for exposure-mediator interaction, we modeled interactions between meconium acetaminophen and birth outcomes on ADHD in separate models for each birth outcome.…”

Section: Discussionmentioning

confidence: 99%

“…Measuring chemicals in meconium, the first feces of newborn infants, has proven to be an effective, non-invasive method to assess cumulative prenatal exposures. 22,26,27 Chemicals in meconium are known to have passed through the fetus and into the fetal intestinal tract, [28][29][30][31] making meconium an ideal substrate for measuring in utero exposures. Furthermore, meconium measurements reflect cumulative exposures during the 2 nd and 3 rd trimesters of pregnancy, as xenobiotics and their metabolites are deposited in meconium throughout that period.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort

Baker

Burris

Bloomquist

et al. 2021

Preprint

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Background Although we previously reported an association of prenatal acetaminophen exposure with more than two-fold increased odds of child ADHD, it is unknown whether prenatal acetaminophen is associated with adverse birth outcomes, and if birth outcomes may mediate the association of prenatal acetaminophen with ADHD. Methods This birth cohort from Sherbrooke, Quebec, Canada, included 773 live births. Mothers with no thyroid disease enrolled at their first prenatal care visit or delivery. Acetaminophen was measured in meconium for 393 children at delivery. Physician diagnosis of ADHD was determined when children were 6-7 years old. We first tested associations of prenatal acetaminophen with birthweight, preterm birth, gestational age, and small and large for gestational age. Then we assessed whether these birth outcomes mediate the association of prenatal acetaminophen with ADHD. We imputed missing data via multiple imputation and used inverse probability weighting to account for confounding and selection bias. Results Acetaminophen was detected in 222 meconium samples (56.5%). Prenatal acetaminophen exposure was associated with decreased birthweight by 136 grams (beta = -136; 95%CI [-229, -43]), 20% increased weekly hazard of delivery (hazard ratio = 1.20; 95%CI [1.00, 1.43]), and over 60% decreased odds of being born large for gestational age (odds ratio = 0.38; 95%CI [0.20, 0.75]). There was no evidence for adverse birth outcomes mediating the association of prenatal acetaminophen with child ADHD. Conclusions Although unobserved confounding and confounding by indication are possible, these results warrant further investigation into adverse perinatal effects of prenatal acetaminophen exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort

Baker

Burris

Bloomquist

et al. 2021

Preprint

Self Cite

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“…An alarming discovery is the fact that the effects associated with exposure to XEs may manifest in subsequent generations [ 58 , 59 ]. In recent years, XEs exposure has been linked with impaired memory and learning processes, as well as with Attention-Deficit Hyperactivity Disorder in children [ 60 , 61 , 62 ].…”

Section: Xenoestrogens—environmental Estrogensmentioning

confidence: 99%

NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

Nowak

Jabłońska

Ratajczak–Wrona

2021

Cells

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The proper functioning of the immune system is critical for an effective defense against pathogenic factors such as bacteria and viruses. All the cellular processes taking place in an organism are strictly regulated by an intracellular network of signaling pathways. In the case of immune cells, the NF-κB pathway is considered the key signaling pathway as it regulates the expression of more than 200 genes. The transcription factor NF-κB is sensitive to exogenous factors, such as xenoestrogens (XEs), which are compounds mimicking the action of endogenous estrogens and are widely distributed in the environment. Moreover, XE-induced modulation of signaling pathways may be crucial for the proper development of the immune system. In this review, we summarize the effects of XEs on the NF-κB signaling pathway. Based on our analysis, we constructed a model of XE-induced signaling in immune cells and found that in most cases XEs activate NF-κB. Our analysis indicated that the indirect impact of XEs on NF-κB in immune cells is related to the modulation of estrogen signaling and other pathways such as MAPK and JAK/STAT. We also summarize the role of these aspects of signaling in the development and further functioning of the immune system in this paper.

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“…Urinary paraben has been established as a valid biomarker for human biomonitoring to characterize exposure levels [16][17][18]. In particular, high detection frequencies (≥ 98%) of several parabens including methyl-paraben (MeP), ethyl-paraben (EtP), and propyl-paraben (PrP) have been observed in urine samples [19,20].…”

Section: Introductionmentioning

confidence: 99%

Environmental Paraben Exposure and Risk of Thyroid Cancer and Benign Nodules: A Pilot Study

Wu¹,

Zhu²,

Liu³

et al. 2021

Preprint

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Parabens are widely used as preservatives, which have been found to affect thyroid function in toxicological studies. However, population studies on whether they are associated with thyroid tumor remain unclear. This study aims to investigate the relationship between environmental paraben exposure and thyroid cancer and benign nodules. The detectable percentages of methyl paraben, ethyl paraben, and propyl paraben in the urinary samples of 425 study subjects were 99.06%, 95.29% and 92.00%, respectively. In the single pollutant model, we found statistically significant difference between certain parabens and thyroid cancer/ benign nodules. Further, we found the mixture effect of parabens on increased risk of thyroid cancer (OR = 0.24, 95% CI: 0.18, 0.31) and benign nodule (OR =1.33, 95% CI: 0.86, 1.80). The significant gender-associated effects were found in associations with certain parabens and thyroid cancer and benign nodules (Both P for interactions < 0.05). Overall, our results showed that individual exposure of paraben mixtures may be associated with the risk of thyroid cancer and benign nodules, and there were gender differences.

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Methylparaben in meconium and risk of maternal thyroid dysfunction, adverse birth outcomes, and Attention-Deficit Hyperactivity Disorder (ADHD)

Cited by 51 publications

References 54 publications

Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort

Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort

NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

Environmental Paraben Exposure and Risk of Thyroid Cancer and Benign Nodules: A Pilot Study

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