Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl3-induced neurotoxicity mouse model

Khalid, Anibah; Abbasi, Umme Aimen; Amber, Sanila; Sumera, Sumera; Mirza, Fatima Javed; Asif, Muhammad; Javed, Aneela; Zahid, Saadia

doi:10.1007/s11033-020-05864-y

Cited by 12 publications

(12 citation statements)

References 52 publications

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“…By contrast, our earlier findings also highlighted the potential of R. officinalis to enhance memory and affect synaptic regulation in the Aβ 1-42 -induced AD mouse model (Mirza et al, 2021). Likewise, another study by our group showed the therapeutic potential of R. officinalis and MPH to improve cognition and regulate inflammation, synaptic gene expression, and hippocampal neuronal density in mouse models of AlCl 3 -induced neurotoxicity (Khalid et al, 2020).…”

Section: Introductioncontrasting

confidence: 59%

“…42570. R. officinalis extract was prepared according to the protocol described by Khalid et al (2020). R. officinalis (500 g) leaves were ground to fine powder form and allowed to pass through 80 mesh sieves.…”

Section: Rosmarinus Officinalis Extract Preparationmentioning

confidence: 99%

“…MPH, and 100 mg/kg (i.p.) R. officinalis extract (Khalid et al, 2020) for 5 days. Aluminum chloride (AlCl 3 ) (300 mg/kg) (Amber et al, 2018;Khalid et al, 2020) was given in drinking water with normal feed for 15 days to groups 5, 6, 7, and 8 (n = 32).…”

Section: Animal Treatmentmentioning

confidence: 99%

“…R. officinalis extract (Khalid et al, 2020) for 5 days. Aluminum chloride (AlCl 3 ) (300 mg/kg) (Amber et al, 2018;Khalid et al, 2020) was given in drinking water with normal feed for 15 days to groups 5, 6, 7, and 8 (n = 32). After the development of AlCl 3 -induced AD models, the animals of groups 5, 6, 7, and 8 were switched to normal drinking water and those of groups 5, 6, and 7 were administered with intraperitoneal (i.p.)…”

Section: Animal Treatmentmentioning

confidence: 99%

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Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

2022

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Alzheimer’s disease (AD) is a neurological illness that causes severe cognitive impairment. AD patients also experience at least one of the neuropsychiatric symptoms including apathy, depression, and anxiety during the course of their life. Acetylcholine esterase inhibitors are the available treatment options to alleviate cognitive deficits, whereas methylphenidate (MPH), a psychostimulant, is considered for the treatment of apathy in AD patients. Rosmarinus officinalis, a perennial herb, has been potentially known to have antioxidant and anti-inflammatory properties. The present study investigated the potential effects of MPH and R. officinalis in comparison with the standard drug, Donepezil, on cognition, anxiety, and depression in the AlCl3-induced mouse model of AD. The animals were divided into eight groups (n = 8, each). The results revealed that the MPH- and R. officinalis-treated groups significantly improved memory impairment, whereas R. officinalis substantially reduced depression and anxiety as compared with other treatment groups. MPH treatment induced an antidepressant effect and increased anxiety-like behavior. Moreover, the AlCl3 exposure led to the formation of amyloid beta (Aβ) plaques in mice hippocampus; however, none of the tested drugs caused a significant reduction in amyloid burden at the selected doses. The present study suggested the potential of R. officinalis to improve memory as well as neuropsychiatric symptoms in AD. Although R. officinalis improved cognitive abilities, it did not reduce the amyloid plaque burden, which indicates that the memory-enhancing effects of R. officinalis are due to some alternate mechanism that needs to be explored further.

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Section: Introductioncontrasting

confidence: 59%

Section: Rosmarinus Officinalis Extract Preparationmentioning

confidence: 99%

Section: Animal Treatmentmentioning

confidence: 99%

Section: Animal Treatmentmentioning

confidence: 99%

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Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

2022

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“…Inflammation is a defensive response of a non-specific natural immune system, a set of complex response systems caused due to foreign pathogens, tissue injury, toxic chemicals, and trauma ( Khalid et al, 2020 ), and a self-limiting healing process characterized by swelling of tissue, redness and pain. When inflammation becomes prolonged, it enhances tissue inflammation and contributes to various chronic autoimmune pathologies like rheumatoid arthritis (RA).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Angiogenic Aattributes of Moringa olifera Lam. and its Nanoclay-Based Pectin-Sericin films

Buabeid¹,

Yaseen

Asif

et al. 2022

Front. Pharmacol.

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Background: Inflammation is a strong reaction of the non-specific natural immune system that helps to start protective responses against encroaching pathogens and develop typical immunity against intruding factors. However, prolonged inflammation may lead to chronic autoimmune diseases. For thousands of years, medicinal plants have served as an excellent source of treatment for chronic pathologies such as metabolic diseases.Purpose: The present study aims to evaluate the anti-inflammatory and anti-angiogenic potential of Moringa olifera Lam. extract (MO) and Moringa-loaded nanoclay films.Methods: The extract preparation was done through the maceration technique using absolute methanol (99.7%) and labelled as Mo. Me. Mo. Me-loaded nanoclay-based films were prepared by using pectin and sericin (Table 1). The in vitro studies characterized the film thickness, moisture, and phytochemical contents. The in vivo anti-inflammatory tests involved using a cotton pellet-induced granuloma model assay. In addition, the chick chorioallantoic membrane (CAM) assay was employed for angiogenesis activity.Results: The phytochemical analysis of the extract confirmed the presence of alkaloids, glycosides, flavonoids and phytosterol. This extract contained quercetin in a large quantity. Cotton-pellet induced granuloma model study revealed a comparable (p > 0.05) effect of a high dose of Mo. Me (500 mg/kg) as compared with standard drug. Noteworthy, data obtained through the RT-PCR technique manifested the dose-dependent anti-oedematous effect of Moringa olifera via downregulation of TNF-α and interleukin-1ß. The findings of the CAM assay exhibited a remarkable anti-angiogenic activity of Mo. Me loaded nanoclay films, showing diffused vasculature network in the macroscopic snapshot.Conclusion:Moringa olifera and its nanocomposite films have therapeutic potential against inflammation.

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Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D‐galactose/AlCl₃ in mice

Aihaiti,

Shi,

Liu

et al. 2023

Food Science & Nutrition

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Nervonic acid (NA) is a kind of ultra‐long‐chain monounsaturated fatty acid, which can repair nerve cell damage caused by oxidative stress. Alzheimer's disease (AD) is a nervous system disease and often accompanied by the decline of learning and memory capacity. In this study, the combined dose of D‐galactose/AlCl3 was used to establish a mouse model of AD. Meanwhile, the mice were treated with different doses of NA (10.95 and 43.93 mg/kg). The results showed that NA delayed the decline of locomotion and learning ability caused by D‐galactose/AlCl3, increased the activity of total superoxide dismutase, catalase, glutathione peroxidase, and reduced the content of malondialdehyde in vivo. Besides, NA reduced the levels of interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), aspartate aminotransferase, alanine aminotransferase, increased the levels of 5‐hydroxytryptamine, dopamine, γ‐aminobutyric acid, alleviated the cell morphology damage induced by D‐galactose/AlCl3 in hippocampus and liver tissue. Furthermore, the intervention of NA upregulated the expression levels of PI3K, AKT, and mTOR genes and downregulated the expression levels of TNF‐α, IL‐6, and IL‐1β genes. Therefore, we speculate the intervention of NA could be an effective way in improving cognitive impairment through the activation of PI3K signaling pathway. These results suggest that NA has the potential to be developed as antioxidant drug for the prevention and early therapy of AD.

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Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl3-induced neurotoxicity mouse model

Cited by 12 publications

References 52 publications

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

Anti-Inflammatory and Anti-Angiogenic Aattributes of Moringa olifera Lam. and its Nanoclay-Based Pectin-Sericin films

Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D‐galactose/AlCl₃ in mice

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Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl3-induced neurotoxicity mouse model

Cited by 12 publications

References 52 publications

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

Anti-Inflammatory and Anti-Angiogenic Aattributes of Moringa olifera Lam. and its Nanoclay-Based Pectin-Sericin films

Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D‐galactose/AlCl3 in mice

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Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D‐galactose/AlCl₃ in mice