Methylphenidate, cognition, and epilepsy

Adams, Jennifer; Alipio-Jocson, Valerie; Inoyama, Katherine; Bartlett, Victoria; Sandhu, Saira; Oso, Jemima; Barry, John J.; Loring, David W.; Meador, Kimford J.

doi:10.1212/wnl.0000000000003564

Cited by 28 publications

(11 citation statements)

References 38 publications

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“…There has been increasing emphasis on screening and early identification of these problems, but critical are systematic intervention trials to improve life status. Unfortunately, there are few non-pharmacological intervention that have been demonstrated to be successful in epilepsy patients (Adams et al, 2017). These are slowly beginning to appear and will increase in the future (Jackson, Makin, & Baker, 2015; Ramaratnam, Baker, & Goldstein, 2008) and will be critical to improving patient life outcomes.…”

Section: Where Is the Neuropsychology Of Epilepsy Headed During The Nmentioning

confidence: 99%

“…Although there has been increasing emphasis on screening and early identification of comorbidities, there is a clear need for systematic intervention trials to improve practice and patient outcomes. Appearing are reports of interventions designed to improve memory and cognition (Adams et al, 2017; Caller et al, 2016; Del Felice et al, 2017; Farina, Raglio, & Giovagnoli, 2015; Jackson, Makin, & Baker, 2015), mood disorders (Gandy, Sharpe, & Perry, 2013), and epilepsy self-management (Jobst & MEW network, 2017; Shegog et al, 2013; Wagner et al, 2017). Both pharmacologic and behavioral interventions will be critical to improving patient life outcomes in patients with chronic epilepsy (Del Felice et al, 2017) and those who have undergone epilepsy surgery (Mazur-Mosiewicz et al, 2015).…”

Section: Where Will (Should) Neuropsychology Head During the Next Decmentioning

confidence: 99%

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Paradigm Shifts in the Neuropsychology of Epilepsy

Hermann

Loring

Wilson

2017

J Int Neuropsychol Soc

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This article reviews the major paradigm shifts that have occurred in the area of the application of clinical and experimental neuropsychology to epilepsy and epilepsy surgery since the founding of the International Neuropsychological Society. The five paradigm shifts discussed include: 1) The neurobiology of cognitive disorders in epilepsy – expanding the landscape of syndrome-specific neuropsychological impairment; 2) pathways to comorbidities: bidirectional relationships and their clinical implications; 3) discovering quality of life: The concept, its quantification and applicability; 4) outcomes of epilepsy surgery: challenging conventional wisdom; and 5) Iatrogenic effects of treatment: cognitive and behavioral effects of antiepilepsy drugs. For each area we characterize the status of knowledge, the key developments that have occurred, and how they have altered our understanding of the epilepsies and their management. We conclude with a brief overview of where we believe the field will be headed in the next decade which includes changes in assessment paradigms, moving from characterization of comorbidities to interventions; increasing development of new measures, terminology and classification; increasing interest in neurodegenerative proteins; transitioning from clinical seizure features to modifiable risk factors; and neurobehavioral phenotypes. Overall, enormous progress has been made over the lifespan of the INS with promise of ongoing improvements in understanding of the cognitive and behavioral complications of the epilepsies and their treatment. (JINS, 2017,23, 791–805)

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Section: Where Is the Neuropsychology Of Epilepsy Headed During The Nmentioning

confidence: 99%

Section: Where Will (Should) Neuropsychology Head During the Next Decmentioning

confidence: 99%

Paradigm Shifts in the Neuropsychology of Epilepsy

Hermann

Loring

Wilson

2017

J Int Neuropsychol Soc

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“…Efek OAE dapat meningkatkan stres oksidatif pada otak yang menyebabkan kerusakan neuronal hingga terjadinya suatu gangguan kognitif pada penyandang epilepsi. 34 Efek OAE bersifat fleksibel; bila obat tersebut dihentikan maka gangguan fungsi kognitif berangsur membaik. 33,34 Penyandang epilepsi harus minum obat secara rutin.…”

Section: Bahasanunclassified

“…34 Efek OAE bersifat fleksibel; bila obat tersebut dihentikan maka gangguan fungsi kognitif berangsur membaik. 33,34 Penyandang epilepsi harus minum obat secara rutin. Pengawasan ketat meminum obat oleh keluarga dapat membantu prognosis yang sejalan dengan penelitian yang dilakukan Oktaviana et al 35 yang meloprkan adanya hubungan kuat antara dukungan keluarga dan kepatuhan minum obat Dalam pemeriksaan MMSE (Tabel 3), sebagian besar pasien mangalami gangguan memori diikuti dengan atensi.…”

Section: Bahasanunclassified

Gambaran Fungsi Kognitif pada Pasien Epilepsi di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado

Sigar¹,

Kembuan²,

Mahama³

2017

eCl

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Epilepsy is one of most common neurological disorders that causes cognitive decline. This stuayd was aimed to ascertain the overview of cognitive function in epilepsy patients at the Neurology Clinic of Prof Dr. R. D. Kandou Hospital Manado. This was a prospective descriptive study with a cross-sectional design. Data were obtained through anamnesis and direct test to 35 epileptic patients by using questionnaire, MMSE, and Ina-MoCA instruments in the Neurology Clinic of Prof. Dr. R. D. Kandou Hospital Manado from October to November 2017. The results MMSE showed 77.10% of patients had normal cognitive function. Meanwhile, the Ina-MoCa resulted in 89% of respondents suffering from cognitive decline. Conclusion: There were impaired cognitive functions ranging from mild to severe in epileptic patients that could affect their quality of life and functional status.Keywords: epilepsy, cognitive function Abstrak: Epilepsi adalah salah satu gangguan neurologik yang terbanyak yang menyebabkan gangguan fungsi kognitif. Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien epilepsi di Poliklinik Saraf RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif prospektif dengan desain potong-lintang. Pengumpulan data diperoleh melalui wawancara dan pengujian langsung terhadap pasien epilepsy yang berjumlah 35 orang. Penelitian ini menggunakan kuesioner, serta instrumen MMSE dan Ina-MoCA dilakukan di Poliklinik Saraf RSUP Prof Dr. R. D. Kandou Manado sejak bulan Oktober s/d November 2017. Hasil pemeriksaan dengan MMSE menunjukkan 77,10% dari pasien dengan fungsi kognitif normal sedangkan pemeriksaan dengan Ina-MoCA menunjukkan 89% dari pasien mengalami gangguan fungsi kognitif. Simpulan: Terdapat gangguan fungsi kognitif ringan-berat pada pasien epilepsi yang dapat memengaruhi kualitas hidup dan status fungsional.Kata kunci: epilepsi, fungsi kogntif

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“…A Swedish study involving more than 21,000 children with seizures, showed no evidence of increased risk of seizures from ADHD medications [61]. Preliminary findings in people with epilepsy also suggest that methylphenidate may be an effective and safe option for improving cognition and quality of life [62]. These data suggest that stimulants, methylphenidate in particular, can be safely used in the context of PTE but more studies are needed.…”

Section: Is the Management Of Psychiatric Disorders In Pte Different mentioning

confidence: 98%

Psychiatric aspects of posttraumatic epilepsy: A still unexplored area

Mula

2019

Epilepsy & Behavior

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Traumatic brain injury (TBI) represents one of the most common causes of death and disability in young people and post-traumatic epilepsy (PTE) accounts for 10% to 20% of all symptomatic epilepsies. However, PTE is still a relatively underappreciated condition. This paper is aimed at reviewing current knowledge about psychiatric comorbidities of PTE, looking in particular at the nature of the relationship between traumatic brain injury, psychiatric problems and epilepsy, at the phenomenology of psychiatric disorders in PTE and how to manage them. Data on psychiatric comorbidities of PTE are almost non-existing and this is a paradox considering that TBI itself is burdened by a number of cognitive and psychiatric sequalae which can profoundly affect the everyday life of these patients. Preliminary data seem to suggest that the bidirectional relationship between epilepsy and psychiatric disorders is maintained in TBI and people with a psychiatric condition at the time of the TBI, or as a consequence of it, are at increased risk of developing PTE and vice versa. However, a number of questions are still unanswered concerning the genetic and environmental contributors, the phenomenology of psychiatric disorders in PTE and how to prevent and address them properly. Further research in this area is urgently needed in order to provide the best possible care to people with PTE.

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Methylphenidate, cognition, and epilepsy

Abstract: This study provides Class II evidence that single doses of MPH improve cognitive performance on some measures of attention and processing speed in patients with epilepsy and cognitive complaints.

Cited by 28 publications

References 38 publications

Paradigm Shifts in the Neuropsychology of Epilepsy

Paradigm Shifts in the Neuropsychology of Epilepsy

Gambaran Fungsi Kognitif pada Pasien Epilepsi di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado

Psychiatric aspects of posttraumatic epilepsy: A still unexplored area

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