Methylphenidate cross-sensitization with amphetamine is dose dependent but not age dependent

Yuan, Anthony; Kharas, Natasha; King, Nicholas; Peng, Yang; Dafny, Nachum

doi:10.1016/j.bbr.2022.114178

Cited by 1 publication

(1 citation statement)

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“…The primary objective of this study was to address the pivotal question of which intervention-physical activity or medication-plays a determinative role in the observed cognitive enhancement, as documented in prior research [22]. This research endeavors to offer alternative a-aches to enhance the well-being of individuals with ADHD, aiming to mitigate reliance on medications due to their recognized limitations and potential side effects [27,28].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of working on an active desktop treadmill workstation on cognitive performance among ADHD university students: A randomized control trial

Korn,

Moran,

Koren

et al. 2024

Preprint

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Background Working on a walking treadmill was found to be effective and beneficial not only from health promotion perspective, but in cognitive performance for people with ADHD (attention deficit hyperactivity disorder). This study explores the impact of cognitive enhancement medications, physical activity of walking on a treadmill, and their combination on cognitive performance among individuals diagnosed with ADHD. The aim is to determine whether cognitive performance gains are achieved through medication, physical activity, or the synergistic effect of both. Methods A randomized controlled trial involved 25 undergraduate students (85% female; Mean age = 23; Standard deviation = 3.2), diagnosed with ADHD, distributed across four groups: Walking with medications, walking without medications, sitting with medications, and sitting without medications. Cognitive performance was assessed using repeated measures in the Stroop test, Barrat scale, and work break patterns. Results Cognitive performance, as evaluated by the Stroop test, exhibited significant enhancements only in response to medication usage. Walking or sitting modes alone did not yield discernible effects. Among the modes examined, the highest mean error count was observed in the sitting without medication condition (M = 5.08, SD = 7.40), followed by walking without medication (M = 4.60, SD = 5.35) and walking with medication (M = 3.40, SD = 5.18). The lowest error mean occurred while under the influence of medication in the sitting mode (M = 1.84, SD = 2.44). Other Stroop and Barrat results displayed no significant inter-mode differences. Walking without medication led to significantly more frequent and longer breaks. Conclusions Cognitive enhancement medication emerged as the sole influential factor contributing to improved cognitive performance. Treadmill walking did not yield cognitive performance benefits compared to sitting, nor did it yield any detriment. These findings underscore the necessity for further investigation into diverse attention disorders.

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Section: Discussionmentioning

confidence: 99%