Methylphenidate Disrupts Social Play Behavior in Adolescent Rats

Vanderschuren, Louk J. M. J.; Trezza, Viviana; Griffioen-Roose, Sanne; Schiepers, Olga J.G.; Leeuwen, Natascha Van; Vries, Taco J. De; Schoffelmeer, Anton N. M.

doi:10.1038/npp.2008.10

Cited by 88 publications

(161 citation statements)

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“…There is a close relationship between the length of social isolation and the amount of social play behavior expressed during testing (Niesink and Van Ree, 1989;Vanderschuren et al, 1995Vanderschuren et al, , 2008. Therefore, we assumed that longer social isolation would enhance responding for social play as well as its expression.…”

Section: Discussion An Operant Conditioning Task For Social Playmentioning

confidence: 99%

“…Administration of the α2-adrenoreceptor agonist clonidine and the α2-adrenoceptor antagonist RX821002 reduced and enhanced social play, respectively (Normansell and Panksepp, 1985;Siviy et al, 1994;Siviy and Baliko, 2000). Furthermore, amphetamine, methylphenidate, and the noradrenaline reuptake inhibitor atomoxetine reduced social play through stimulation of α2-adrenoceptors (Beatty et al, 1982;Vanderschuren et al, 2008;Achterberg et al, 2014). However, it is unknown whether dopamine and noradrenaline are involved in the motivational properties of social play behavior.…”

Section: Introductionmentioning

confidence: 99%

“…To verify that our operant conditioning task was sensitive to differences in social motivation, we compared rats that were socially isolated for 2 or 24 h, since these isolation periods are known to induce moderate and maximal increases in social play behavior, respectively (Niesink and van Ree, 1989;Vanderschuren et al, 1995Vanderschuren et al, , 2008. All rats acquired the task, ie, pressed the active lever for the opportunity for a social interaction under the FR-1 schedule of reinforcement.…”

Section: Validation Of the Operant Conditioning Taskmentioning

confidence: 99%

“…Atomoxetine, α-flupenthixol and RX821002 were administered intraperitoneally (i.p.). Drug doses and pretreatment intervals were based on previous studies (Baarendse et al, 2013a, b;Baarendse and Vanderschuren, 2012;Trezza and Vanderschuren, 2009;Vanderschuren et al, 2008;Achterberg et al, 2014). Drug doses were calculated as salt.…”

Section: Drugsmentioning

confidence: 99%

“…For example, treatment with dopamine receptor agonists and antagonists alters the expression of social play behavior (Niesink and Van Ree, 1989;Siviy et al, 1996;Vanderschuren et al, 2008;Trezza and Vanderschuren, 2009). In addition, the stimulation of social play by endocannabinoids, ethanol, and nicotine depends upon dopamine receptor stimulation Vanderschuren, 2008, 2009;Trezza et al, 2009b).…”

Section: Introductionmentioning

confidence: 99%

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Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

Achterberg

Kerkhof

Servadio

et al. 2015

Neuropsychopharmacol

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Social play behavior, abundant in the young of most mammalian species, is thought to be important for social and cognitive development. Social play is highly rewarding, and as such, the expression of social play depends on its pleasurable and motivational properties. Since the motivational properties of social play have only sporadically been investigated, we developed a setup in which rats responded for social play under a progressive ratio schedule of reinforcement. Dopaminergic neurotransmission plays a key role in incentive motivational processes, and both dopamine and noradrenaline have been implicated in the modulation of social play behavior. Therefore, we investigated the role of dopamine and noradrenaline in the motivation for social play. Treatment with the psychostimulant drugs methylphenidate and cocaine increased responding for social play, but suppressed its expression during reinforced play periods. The dopamine reuptake inhibitor GBR-12909 increased responding for social play, but did not affect its expression, whereas the noradrenaline reuptake inhibitor atomoxetine decreased responding for social play as well as its expression. The effects of methylphenidate and cocaine on responding for social play, but not their play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol. In contrast, pretreatment with the α2-adrenoceptor antagonist RX821002 prevented the play-suppressant effect of methylphenidate, but left its effect on responding for social play unaltered. In sum, the present study introduces a novel method to study the incentive motivational properties of social play behavior in rats. Using this paradigm, we demonstrate dissociable roles for dopamine and noradrenaline in social play behavior: dopamine stimulates the motivation for social play, whereas noradrenaline negatively modulates the motivation for social play behavior and its expression.

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Section: Discussion An Operant Conditioning Task For Social Playmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Validation Of the Operant Conditioning Taskmentioning

confidence: 99%

Section: Drugsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

Achterberg

Kerkhof

Servadio

et al. 2015

Neuropsychopharmacol

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Measuring Play Fighting in Rats: A Multilayered Approach

et al. 2022

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Rough-and-tumble play or play fighting is an important experience in the juvenile period of many species of mammals, as it facilitates the development of social skills, and for some species, play fighting is retained into adulthood as a tool for assessing and managing social relationships. Laboratory rats have been a model species for studying the neurobiology of play fighting and its key developmental and social functions. However, play fighting interactions are complex, involving competition and cooperation; therefore, no single measure to quantify this behavior is able to capture all its facets. Therefore, in this paper, we present a multilayered framework for scoring all the relevant facets of play that can be affected by experimental manipulations and the logic of how to match what is measured with the question being asked.

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The effects of stress on play and home cage behaviors in adolescent male rats

Klein

Padow

Romeo

2009

Developmental Psychobiology

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One prominent feature of adolescence is the high frequency of social behaviors, such as play. Engaging in these behaviors appears necessary for proper socio-emotional development as social isolation during adolescence typically leads to behavioral dysfunctions in adulthood. The present experiments examined the effects of stress on social and nonsocial behaviors in group housed adolescent male rats. We found that acute restraint stress led to a complete inhibition of play (e.g., nape contacts and pins) and reduced social investigations in pre- (28 days), mid- (35 days), and late-adolescent (42 and 49 days) animals. A follow-up study, however, found that restraint-induced suppression of play and social investigations was transient such that experimental animals engage in these behaviors at levels similar to those of controls 1 hr after termination of the stressor. We also found that exposure to repeated restraint stress throughout adolescence led to a decrease in social investigations, while leaving play largely unaffected. Interestingly, in all of the experiments, nonsocial behaviors (e.g., eating, drinking, grooming) were unaffected by restraint, suggesting these effects of stress are specific to social behaviors. Together, these data indicate that both acute and repeated stress significantly affect social behaviors during adolescence.

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Methylphenidate Disrupts Social Play Behavior in Adolescent Rats

Cited by 88 publications

References 88 publications

Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats

Measuring Play Fighting in Rats: A Multilayered Approach

The effects of stress on play and home cage behaviors in adolescent male rats

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